The meselson‐stahl experiment

Szeberényi, József

doi:10.1002/bmb.20602

Cited by 2 publications

(2 citation statements)

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“…This experiment enables any laboratory to determine whether pathogen proteins display the heavier nitrogen-15 ( 15 N) isotope after a specific period of bacterial culture, thereby establishing that viral proteins result from reproduction within the bacterial cell. The Meselson-Stahl experiment [71] provided researchers with insights into DNA replication, offering a fundamental understanding of genetic phenomena related to heredity and disease, all based on the utilization of nitrogen isotopes. This methodology represents a significant milestone in biology and biochemistry; however, it is important to note that the use of 15 N nitrogen cannot independently corroborate microscopy data.…”

Section: Considerations On the Importance Of Radioisotope Testing As ...mentioning

confidence: 99%

Who Is the Intermediate Host of RNA Viruses? A Study Focusing on SARS-CoV-2 and Poliovirus

Brogna,

Bisaccia,

Costanzo

et al. 2024

Microorganisms

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The COVID-19 pandemic has sparked a surge in research on microbiology and virology, shedding light on overlooked aspects such as the infection of bacteria by RNA virions in the animal microbiome. Studies reveal a decrease in beneficial gut bacteria during COVID-19, indicating a significant interaction between SARS-CoV-2 and the human microbiome. However, determining the origins of the virus remains complex, with observed phenomena such as species jumps adding layers to the narrative. Prokaryotic cells play a crucial role in the disease’s pathogenesis and transmission. Analyzing previous studies highlights intricate interactions from clinical manifestations to the use of the nitrogen isotope test. Drawing parallels with the history of the Poliovirus underscores the need to prioritize investigations into prokaryotic cells hosting RNA viruses.

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Section: Considerations On the Importance Of Radioisotope Testing As ...mentioning

confidence: 99%

Who Is the Intermediate Host of RNA Viruses? A Study Focusing on SARS-CoV-2 and Poliovirus

Brogna,

Bisaccia,

Costanzo

et al. 2024

Microorganisms

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“…Though, Matthew Meselson and Franklin Stahl described how DNA replicates one year later, in 1958. Through the Meselson-Stahl experiment, they discovered that DNA replicates in a semiconservative way[57]. Semiconservative means that two copies of the original DNA molecule are produced, and each of them contains one original strand and one newly synthesized strand (see Figure2.4).…”

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confidence: 99%

Understanding the Code of Life: Holistic Conceptual Modeling of the Genome

S.¹

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Over the last few decades, advances in sequencing technology have produced significant amounts of genomic data, which has revolutionised our understanding of biology. However, the amount of data generated has far exceeded our ability to interpret it.Deciphering the code of life is a grand challenge. Despite our progress, our understanding of it remains minimal, and we are just beginning to uncover its full potential, for instance, in areas such as precision medicine or pharmacogenomics.The main objective of this thesis is to advance our understanding of life by proposing a holistic approach, using a model-based approach, consisting of three artifacts: i) a conceptual schema of the genome, ii) a method for its application in the real-world, and iii) the use of foundational ontologies to represent domain knowledge in a more unambiguous and explicit way. The first two contributions have been validated by implementing genome information systems based on conceptual models. The third contribution has been validated by empirical experiments assessing whether using foundational ontologies leads to a better understanding of the genomic domain.The artifacts generated offer significant benefits. First, more efficient data management processes were produced, leading to better knowledge extraction processes. Second, a better understanding and communication of the domain was achieved. v Els artefactes generats ofereixen importants beneficis. En primer lloc, s'han generat processos de gestió de dades més eficients, la qual cosa ha permés millorar els processos d'extracció de coneixements. En segon lloc, s'ha aconseguit una millor comprensió i comunicació del domini.

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The meselson‐stahl experiment

Abstract: Terms to be familiar with before you start to solve the test: DNA replication, nitrogen isotopes, density labeling, cesium chloride density gradient centrifugation, ultraviolet absorption, DNA denaturation, circular and linear DNA, superspiralization, superhelical DNA, and template.

Cited by 2 publications

References 10 publications

Who Is the Intermediate Host of RNA Viruses? A Study Focusing on SARS-CoV-2 and Poliovirus

Who Is the Intermediate Host of RNA Viruses? A Study Focusing on SARS-CoV-2 and Poliovirus

Understanding the Code of Life: Holistic Conceptual Modeling of the Genome

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