“…Further, since the MCS-12 can be considered a valid tool to detect and monitor the presence and prevalence of depressive disorders, it seems that patients on both AAPs and antidepressants are more likely to have uncontrolled depressive symptoms than their counterparts on antidepressants only. 55 This can be partly explained by the high propensity of these medications to cause undesirable and serious side effects, such as involuntary movements, weight gain, and increased risk of type 2 diabetes, myocardial infarction, stroke, hyperlipidemia, QTc interval prolongation, and sexual side effects. 56 These adverse effects are even potentiated when these medications are coadministered with antidepressants such as Selective Serotonin Reuptake inhibitors (SSRIs).…”