The menopause and obesity

Lovejoy, Jennifer C.

doi:10.1016/s0095-4543(03)00012-5

Cited by 105 publications

(73 citation statements)

References 34 publications

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“…Menopause tends to be associated with an increased risk of obesity and a shift to an abdominal fat distribution with associated increase in health risk 21 . In this study we have measured serum lipid profile in 66 cases of postmenopausal central obese women and 56 nonobese control postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Khanam

Khan²,

Rahman

et al. 2014

Chatt Maa Shi Hosp Med Coll J

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Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women. Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant. Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women. Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.

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Section: Discussionmentioning

confidence: 99%

Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Khanam

Khan²,

Rahman

et al. 2014

Chatt Maa Shi Hosp Med Coll J

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“…9 For women, a large weight increase after menopause could be because of the change in hormone levels. 21 Factors that control eating behaviors may also have contributed to the difference. For instance, in a national survey in Japan, 22 younger non-obese women were more likely to regard themselves as overweight than older nonobese women, suggesting a differential body image across generations.…”

Section: Discussionmentioning

confidence: 99%

Overweight and obesity trends among Japanese adults: a 10-year follow-up of the JPHC Study

et al. 2008

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Objective: Limited data are available regarding longitudinal changes in body weight. Here, we describe changes in the prevalences of overweight and obesity and calculated the incidence of these indices during a 10-year follow-up period for a large-scale cohort study in Japan. Design: Longitudinal analysis of data from a population-based cohort study, the Japan Public Health Center (JPHC) Study. Participants: A total of 65 095 Japanese men and women, who were between the ages of 40 and 69 years at baseline and participated in the 5th-and 10th-year follow-up surveys of the JPHC, were enroled in the study. Measurements: Mean body mass index (BMI), calculated using self-reported height and weight, and the prevalences of overweight (BMI X25 kg/m 2 ) and obesity (BMI X30 kg/m 2 ) at each survey period. Incidences of overweight and obesity during the 10-year period. Results: On an average, individuals living in Okinawa had much higher BMIs than those living on the Main islands for all sex and age groups. During the follow-up period, the prevalences of overweight and obesity steadily increased in the cohorts aged less than 50 years at baseline in both sexes. Men in younger cohorts had a higher mean BMI than those in the same age group of older cohorts, whereas the opposite trend was observed in women. The incidence of overweight individuals was greater in Okinawa than on the Main islands and among younger generations than among older ones. Conclusion: A longitudinal analysis at the individual level showed that the prevalences of overweight and obesity increased among middle-aged Japanese participants during the follow-up period. Among men, an increasing prevalence of obesity was observed among the younger generations. These findings should be taken into consideration when planning preventive strategies for obesity and its related diseases.

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“…A correlation between estrogen and adipose tissue mass has been seen in both humans and rodents (Lovejoy, 2003). Estrogen reduces food intake and is also known to decrease adipose tissue mass by increasing lipolysis, but the molecular mechanisms for this phenomenon still remain unclear.…”

Section: Metabolic Diseasesmentioning

confidence: 99%