Comparison of Atherogenic Index of Plasma (AIP) Between Postmenopausal Women with Central Obesity and Postmenopausal Nonobese Women

Abstract

Background: Following menopause there are changes in values of lipid profile parameters. Abdominal obesity has also been linked to significant metabolic abnormalities including changes in lipid parameter values. Atherogenic index of plasma (AIP) calculated as log (TG/HDL-C) has been used as some practitioners as a significant predictor of atherosclerosis. So, we designed this study to observe the pattern of lipid profile parameters and to find out AIP in postmenopausal central obese women and to compare these between postmenopausal women with central obesity and postmenopausal nonobese women. Objectives: To assess the lipid profile status and AIP of postmenopausal women with central obesity and to compare these parameters with that of postmenopausal nonobese women. Materials & Methods: This cross sectional study was carried out in the department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Sixty six postmenopausal women with central obesity and age matched 56 nonobese postmenopausal women were included in the study. Central obesity was defined having waist hip ratio more than 0.8 and BMI <25.0. All statistical analyses were done by SPSS 18.0. p values <0.05 were considered significant. Results: Statistically no significant difference was observed between the central obese women and nonobese women in lipid profile parameters. But AIP was found significantly higher in postmenopausal central obese women. Conclusion: Central obese postmenopausal women may be at higher risk of cardiovascular events compared with postmenopausal nonobese women in spite of no difference in lipid profile parameters as their AIP values are significantly different.

Atherogenic index of plasma and its association with cardiovascular disease risk factors among postmenopausal rural women of Bangladesh

“…However, although the mean AIP was less than the other studies, more than half of the respondents of the present study had elevated AIP (>0.1). At this cut-off value, the proportion of elevated AIP of our study also showed agreement with other studies of Bangladesh 31 , 37 and Africa 30 , 34 for postmenopausal women. However, according to CVD risk classification based on AIP revealed that higher proportion of Bangladeshi women was at the ‘high-risk’ category (AIP > 0.24) compared with African postmenopausal women.…”

“…Another Bangladeshi study showed centrally obese (determined by waist–hip ratio) postmenopausal women had significant difference compared with nonobese for AIP. 37 Regarding the association of blood glucose and AIP, Nansseu et al measured fasting blood glucose as a tool to diagnose diabetes and found significant positive association with AIP. Although this finding was contradicted with our study, another case–control study among prediabetes subjects found significant positive association between AIP and 2-h plasma glucose ( p = 0.001).…”

Lipid Profile and Atherogenic Index of Plasma (AIP) in Vegetarians

“…[13][14][15] Application of AIP as a predictor of cardiovascular diseases may offer new insights. 16 So far we know, no study has been done in vegeterians in our population addressing lipid profle status and AIP. So, we conducted this study in male vegetarians to know their lipid profile and AIP status and to compare it with that of age-matched nonvegetarians.…”