The Menin Gene

Shen, Hsin-Chieh Jennifer; Libutti, Steven K.

doi:10.1007/978-1-4419-0857-5_15

Cited by 1 publication

(1 citation statement)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This condition prompts tumor development in various endocrine and non-endocrine organs, particularly the pituitary gland, pancreatic islet cells, and parathyroid gland. Tumor development is tied to the inactivation of the MEN-1 gene on chromosome 11q13, which typically suppresses tumor formation by regulating cell proliferation [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Coincidental Occurrence of Multiple Endocrine Neoplasia Type 1 and Breast Cancer in a Young Saudi Girl: A Case Study and Genetic Analysis

Alhefdhi,

Alrajhi,

Almady

et al. 2023

Cureus

View full text Add to dashboard Cite

Multiple Endocrine Neoplasia Type 1 (MEN-1) is an autosomal dominant familial disorder associated with tumors in both endocrine and non-endocrine organs. It is uncommon for MEN-1 to coincide with breast cancer. We present a case of a 15-year-old Saudi girl who exhibited the classic symptoms of MEN-1 and subsequently developed breast cancer. The patient’s breast cancer was diagnosed using ultrasonography and core biopsy, and she was treated with surgical interventions. Despite these treatments, her cancer progressed to a metastatic stage, and her overall health deteriorated, leading to cardiopulmonary arrest at a young age. Although the simultaneous appearance of MEN-1 and breast cancer in our patient may suggest a potential link, our comprehensive genetic analysis found no relationship between her MEN-1 mutation and the onset of breast cancer. This suggests that, in this case, the two conditions co-occurred by chance. Nonetheless, additional research is needed to explore potential associations between MEN-1 and breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%