The meloxicam complexes of Co(II) and Zn(II): Synthesis, crystal structures, photocleavage and in vitro DNA-binding

Sanatkar, Tahereh Hosseinzadeh; Hadadzadeh, Hassan; Simpson, Jim; Jannesari, Zahra

doi:10.1016/j.molstruc.2013.06.070

Cited by 26 publications

(17 citation statements)

References 42 publications

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“…The FT‐IR spectra of H 2 mel, Bipy and their metal complexes were obtained and the positions of the significant FT‐IR bands are shown in Figure S1 with the data summarized in Table . H 2 mel shows bands at 3438, 3289, 1620, 1550, 1346 and 1183 cm −1 which can be attributed to the stretching vibrations of ν(OH), ν(NH) amide , ν(CO) amide , ν(CN) thiazoyl , ν(SO 2 ) asym and ν(SO 2 ) sym , respectively . Also, the band corresponding to ν(CN) of Bipy ligand is located at 1578 cm −1 .…”

Section: Resultsmentioning

confidence: 92%

“…Also, the band corresponding to ν(CN) of Bipy ligand is located at 1578 cm −1 . The FT‐IR spectra of the complexes do not have any bands in the region 3289–3200 cm −1 indicating that the NH group of H 2 mel − is involved in a strong intramolecular hydrogen bond to the enolate oxygen . The bands of stretching vibrations for the amide CO group and ν(CN) for thiazoyl ring are shifted to lower wavenumber in the spectra of the complexes which indicates the coordination of H 2 mel through these two groups.…”

Section: Resultsmentioning

confidence: 92%

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Spectroscopic characterization, thermogravimetry, density functional theory and biological studies of some mixed‐ligand complexes of meloxicam and 2,2′‐bipyridine with some transition metals

Sadeek

El‐Hamid

Mohamed

et al. 2019

Applied Organom Chemis

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The mixed‐ligand Mn(II), Fe(III), Ni(II), Cu(II), Zn(II) and Zr(IV) complexes of meloxicam (H2mel) and 2,2′‐bipyridine (Bipy) were prepared and characterized. For all complexes, the analytical and spectroscopic results revealed that H2mel acts in a monobasic bidentate manner through the oxygen of the amide and nitrogen of the thiazole groups, whereas Bipy coordinates through the two nitrogen atoms with slightly distorted octahedral geometry. Thermodynamic parameters (E, ΔS*, ΔH* and ΔG*) were calculated using Coats–Redfern and Horowitz–Metzger methods. The geometries of H2mel and the complexes were carefully studied using density functional theory to predict the properties of materials performed using the hybrid density functional method B3LYP. All studied complexes are soft with respect to H2mel where η varies from 0.096 for Zn(II) complex to 0.067 for Fe(III) complex and σ varies from 10.42 to 14.93 eV, while η and σ for H2mel are 0.14 and 7.14 eV, respectively. The antibacterial activities of the ligands and metal complexes were investigated and the data show that the complexes are active against some bacterial species compared with H2mel.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 92%

Spectroscopic characterization, thermogravimetry, density functional theory and biological studies of some mixed‐ligand complexes of meloxicam and 2,2′‐bipyridine with some transition metals

Sadeek

El‐Hamid

Mohamed

et al. 2019

Applied Organom Chemis

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“…Furthermore, the efficacy of Lornoxicam is due to the high inhibition of prostaglandin biosynthesis [1,5]. Several studies reported the synthesis of coordination compounds using Oxicams as ligands [11][12][13][14]. Some studies have described that Lornoxicam metal complexes have promising antitumor and antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

Study of the thermal behavior in oxidative and pyrolysis conditions of some transition metals complexes with Lornoxicam as ligand using the techniques: TG-DSC, DSC, HSM and EGA (TG-FTIR and HSM-MS)

et al. 2019

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Lornoxicam metal complexes [M(Lor)2(OH2)2]•nH2O, where M represents the bivalent transition metals (Mn(II) to Zn(II)), Lor is Lornoxicam ligand and n = 2.0 or 2.5 were synthesized. The compounds were characterized by elemental analysis (EA), powder X-ray diffraction (PXRD), infrared spectroscopy (FTIR), simultaneous thermogravimetry and differential scanning calorimetry (TG-DSC) under oxidizing and pyrolysis conditions, differential scanning calorimetry (DSC), hot-stage microscopy (HSM) and evolved gas analysis (EGA) by coupled hot-stage microscopy (HSM-MS) and Fourier transform infrared (TG−FTIR). Regardless of the atmosphere, the thermal stability and thermal behavior up to the first two mass loss steps of the anhydrous compound were similar, only differing significantly in the last steps. The main gaseous products released * Corresponding author.

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“…In recent years, many complexes of several NSAIDs with metal ions have been synthesized, with the main goal of producing new better drugs with better pharmacokinetics and pharmacodynamics properties, but also to study their chemical characteristics [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Moreover, some compounds of NSAIDs-metals have showed other pharmacological actions, such as the Cu-diclofenac complex, which presents anti-carcinogenic properties [2].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals

Franzé¹,

Carvalho²,

Gaglieri

et al. 2016

J Therm Anal Calorim

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Complexes of meloxicam with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were prepared by aqueous precipitation. The compounds were characterized by means of X-ray powder diffractometry, infrared spectroscopy, theoretical calculation, elemental analysis (CNH), differential scanning calorimetry, simultaneous TG/DTG-DTA and evolved gas analysis (EGA). The results obtained from the TG/DTG-DTA curves and elemental analysis made it possible to establish the general formula of these compounds as [M(Hmel) 2 (H 2 O) 2 ]nH 2 O, where M = Mn(II), Co(II), Ni(II); Cu(II) and Zn(II); Hmel = meloxicam and n = 2 (Mn, Co, Ni, Zn) and 1 (Cu). The simultaneous TG/ DTG-DTA data provided previously unreported information about the thermal stability and thermal decomposition of these compounds in dynamic air and nitrogen atmospheres. The EGA showed the remarkable influence of the atmosphere in the thermal decomposition mechanism of these complexes, and it was also possible to identify the main gaseous products of thermal degradation. The lowest energy model structure of the Mn(II), Ni(II) and Zin(II) complexes has been proposed by using the density functional theory at the B3LYP/6-311??G(d) level of theory, and the theoretical spectra were calculated. The antibacterial activity of the compounds was also evaluated in relation to S. aureus by the diffusion method in agar, and the compounds showed little activity. The anti-inflammatory activity of the meloxicam-copper complex was also evaluated in vivo by the rat paw edema method. The compound showed no anti-inflammatory activity, which may have been due to loss of intrinsic activity or poor oral absorption caused by low solubility.

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The meloxicam complexes of Co(II) and Zn(II): Synthesis, crystal structures, photocleavage and in vitro DNA-binding

Cited by 26 publications

References 42 publications

Spectroscopic characterization, thermogravimetry, density functional theory and biological studies of some mixed‐ligand complexes of meloxicam and 2,2′‐bipyridine with some transition metals

Spectroscopic characterization, thermogravimetry, density functional theory and biological studies of some mixed‐ligand complexes of meloxicam and 2,2′‐bipyridine with some transition metals

Study of the thermal behavior in oxidative and pyrolysis conditions of some transition metals complexes with Lornoxicam as ligand using the techniques: TG-DSC, DSC, HSM and EGA (TG-FTIR and HSM-MS)

Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals

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