Synthesis, characterization, thermal and spectroscopic studies and bioactivity of complexes of meloxicam with some bivalent transition metals

Abstract

Complexes of meloxicam with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) were prepared by aqueous precipitation. The compounds were characterized by means of X-ray powder diffractometry, infrared spectroscopy, theoretical calculation, elemental analysis (CNH), differential scanning calorimetry, simultaneous TG/DTG-DTA and evolved gas analysis (EGA). The results obtained from the TG/DTG-DTA curves and elemental analysis made it possible to establish the general formula of these compounds as [M(Hmel) 2 (H 2 O) 2 ]nH 2 O, where M = Mn(II), Co(II), Ni(II); Cu(II) and Zn(II); Hmel = meloxicam and n = 2 (Mn, Co, Ni, Zn) and 1 (Cu). The simultaneous TG/ DTG-DTA data provided previously unreported information about the thermal stability and thermal decomposition of these compounds in dynamic air and nitrogen atmospheres. The EGA showed the remarkable influence of the atmosphere in the thermal decomposition mechanism of these complexes, and it was also possible to identify the main gaseous products of thermal degradation. The lowest energy model structure of the Mn(II), Ni(II) and Zin(II) complexes has been proposed by using the density functional theory at the B3LYP/6-311??G(d) level of theory, and the theoretical spectra were calculated. The antibacterial activity of the compounds was also evaluated in relation to S. aureus by the diffusion method in agar, and the compounds showed little activity. The anti-inflammatory activity of the meloxicam-copper complex was also evaluated in vivo by the rat paw edema method. The compound showed no anti-inflammatory activity, which may have been due to loss of intrinsic activity or poor oral absorption caused by low solubility.

Potassium Complexes of Quercetin-5′-Sulfonic Acid and Neutral O-Donor Ligands: Synthesis, Crystal Structure, Thermal Analysis, Spectroscopic Characterization and Physicochemical Properties

“…The release of SO 2 confirms the presence of signals with m/z 48, 50, 64 and 65 in the mass spectra (Figure 5) and the presence of bands at 1400-1300 and 1250-1050 cm −1 in FTIR spectra attributed to asymmetric and symmetric stretching mode of S=O group, respectively (Figure 4a) [54]. The carbonyl sulfide was identified on the basis of characteristic bands at 2070 and 2050 cm −1 in the corresponding FTIR spectra (Figure 4a) [35,53,54].…”

“…The decomposition of the organic part of the complex corresponds to the release of H 2 O, CO 2 , SO 2 , and COS species. The presence of carbon dioxide is evidenced by bands from asymmetric stretching and bending vibrations in the ranges of 2400-2250 cm −1 and 750-600 cm −1 in FTIR spectra (Figure 4a), as well as signals with m/z 12 (C + ), 16 (O + ) and 44 (CO 2 + ) in the mass spectrum (Figure 5) [35,48,49,[51][52][53]. The release of SO 2 confirms the presence of signals with m/z 48, 50, 64 and 65 in the mass spectra (Figure 5) and the presence of bands at 1400-1300 and 1250-1050 cm −1 in FTIR spectra attributed to asymmetric and symmetric stretching mode of S=O group, respectively (Figure 4a) [54].…”

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

“…Additionally, Lawal and co-workers reported an example of a Co(II)-aspirin complex that showed a marked inhibitory effect against B. subtilis [ 127 ]. Moreover, a Ni(II)−meloxicam [ 100 ] complex was found to have stronger antimicrobial activity than free meloxicam ( Table 3 ), and a Mn(II)–meloxicam complex also proved to have better antibacterial activity against E. coli , Coliform , S. aureus , S. typhi , Citrobacter and Listeria compared to the free NSAID ( Table 4 ) ([ 104 ]. Additionally, Ashouri and co-workers synthetized novel Co(II) and Mn(II)−diclofenac coordination compounds that showed enhanced inhibitory activity in comparison with free diclofenac and metal salts [ 128 ].…”

Spectroscopic and molecular docking studies on the binding mechanism of Mobic and lipase

“…Non-steroidal anti-inflammatory drugs can relieve pain and edema to play a role in the treatment of inflammation, however, patients taking non-steroidal antiinflammatory drugs often cause gastritis, gastric ulcer, kidney and liver damage and other adverse symptoms. [1] Mobic is one of the non-steroidal anti-inflammatory drugs [2] and the structural formula is shown in Figure 1. The toxic and side effects of Mobic are much less than those of some other non-steroidal anti-inflammatory drugs (such as dotaline, ibuprofen, etc.).…”