The Melbourne Asthma Study: 1964-1999

Phelan, P. D.; Robertson, Colin F.; Olinsky, Anthony

doi:10.1067/mai.2002.120951

Cited by 443 publications

(313 citation statements)

References 21 publications

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“…There is increasing evidence that lung function ''tracks'' from birth into infancy and childhood, and from childhood into adulthood [6,[24][25][26][27]. In our study, a relationship between infant lung function and spirometry at 5 years of age was also found.…”

Section: Discussionsupporting

confidence: 63%

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

et al. 2012

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Studies of reduced neonatal lung function and wheezing illnesses during childhood show conflicting results. The aim of our study was to assess the association between resistance (Rrs) and compliance (Crs) of the respiratory system by using the single occlusion technique (SOT) and prospectively collected wheezing illnesses during the first 5 years of life in a large birth cohort.SOT was performed during natural sleep before the age of 2 months. Information about wheezing illnesses was collected from the electronic patient file.549 infants had a successful SOT measurement and complete medical records. Every kPa?L -1 ?s -1 increase in Rrs was associated with 10% more consultations in the first 3 years of life. Every 10 mL?kPa -1 increase in Crs was associated with a 14% reduction in consultations in the first 3 years of life, 27% in the fourth to fifth years of life, and a lower probability of having asthma at the age of 5 years (OR 0.66). Children with lateonset or persistent wheezing had significant lower Crs values than their peers.An increased neonatal resistance is associated with more wheezing illnesses during infancy, while a reduced neonatal compliance is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma. @ERSpublications Increased neonatal resistance and reduced neonatal compliance are both associated with more wheezing illnesses

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Section: Discussionsupporting

confidence: 63%

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

et al. 2012

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“…Segundo estudo de coorte realizado na Austrália, estima-se que 30% das crianças com asma evoluem com remissão dos sintomas na idade adulta, 45% serão adultos com crises eventuais e 25% apresentarão asma persistente 9 .…”

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Distribution of severity of asthma in childhood

Simões¹,

Cunha²,

Barreto³

et al. 2010

J Pediatr (Rio J)

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Objective: To estimate the distribution of asthma severity in a population-based sample of children from Salvador, Brazil.Methods: An epidemiologically oriented questionnaire (International Study of Asthma and Allergies in Childhood, ISAAC) and a questionnaire based on criteria used in clinical practice (The Global Initiative for Asthma, GINA) were administered simultaneously to 417 children aged 5 to 12 years who reported symptoms of asthma in the past 12 months. According to the ISAAC instrument, children were classified into severe and non-severe asthma, whereas GINA clinical criteria produced four categories of severity: intermittent, mild persistent, moderate persistent and severe asthma.Results: Ninety children reported symptoms indicative of severity according to the ISAAC questionnaire. According to GINA criteria, 143 children had intermittent asthma, 160 mild persistent, 51 moderate and 43 severe asthma. Agreement between the two instruments was 81.3% (kappa = 0.5). Conclusions:Most asthmatic children in the Salvador urban area have persistent asthma. Agreement between epidemiological and clinical classifications of asthma severity was satisfactory.J Pediatr (Rio J). 2010;86(5):417-423: Asthma, severity, questionnaire, child.

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“…However, there are several epidemiologic studies suggesting that some atopic individuals may loose their propensity to respond to environmental allergens by an IgE immune response (40,41).…”

Section: Perinatal Influences On Ige-mediated Allergymentioning

confidence: 99%

Epigenetic inheritance of fetal genes in allergic asthma

Bousquet

Jacot

Yssel

et al. 2004

Allergy

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Asthma has been associated with an exaggerated T‐helper type 2 (Th2) over Th1 responses to allergic and nonallergic stimuli, which leads to chronic airway inflammation and airway remodeling. In the present article, we propose that many of the genes involved in IgE synthesis and airways (re)modeling in asthma are persistent or reminiscent fetal genes which may not be silenced during early infancy (or late pregnancy). Genes of the embryologic differentiation of ectodermic and endodermic tissues may explain some of the patterns of airway remodeling in asthma. In utero programming leads to gene expression, the persistence of which may be associated with epigenetic inheritance phenomena induced by nonspecific environmental factors. Clear delineation of these issues may yield new information on the mechanisms of asthma and new targets for therapeutic intervention and primary prevention.

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The Melbourne Asthma Study: 1964-1999

Cited by 443 publications

References 21 publications

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

Reduced neonatal lung function and wheezing illnesses during the first 5 years of life

Distribution of severity of asthma in childhood

Epigenetic inheritance of fetal genes in allergic asthma

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