The Melanogenesis Alteration Effects of Achillea millefolium L. Essential Oil and Linalyl Acetate: Involvement of Oxidative Stress and the JNK and ERK Signaling Pathways in Melanoma Cells

Peng, Hsien Yu; Lin, Chih-Chien; Wang, Hsun-Yen; Shih, Ying; Chou, Su‐Tze

doi:10.1371/journal.pone.0095186

Cited by 68 publications

(61 citation statements)

References 28 publications

(31 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The major compound of Salvia sclarea EO (sample 5) was linalyl acetate (45.1%), which was recently demonstrated to account for the anti‐melanogenic action of Achillea millefolium EO, by downregulating tyrosinase activity in α‐MSH‐stimulated B16 cells . However, in our study, EO 5 resulted in a weak mushroom tyrosinase inhibitor, thus suggesting that linalyl acetate may not directly inhibit the enzymatic action and that its anti‐melanogenic effect depended mainly on its ability to interfere with the signalling pathways that trigger tyrosinase gene expression, as also suggested by Peng et al …”

Section: Resultsmentioning

confidence: 52%

Chemical composition and the anti‐melanogenic potential of different essential oils

Fiocco

Arciuli

Arena

et al. 2016

Flavour & Fragrance J

View full text Add to dashboard Cite

Tyrosinase is the key enzyme of melanogenesis, the process that determines skin and hair pigmentation in mammals. In humans, various pigmentary disorders depend on excessive melanin production and accumulation. Moreover, tyrosinase activity can cause the undesirable browning of plant‐derived food. For such reasons, ongoing researches aim at developing effective melanogenesis inhibitors for medical, cosmetic and food applications. Diverse biological activities have been observed for certain plant essential oils (EOs) and their components. In this study, the EOs from nine different plant species were investigated for their anti‐melanogenic potential. The EOs chemical composition was assessed by gas chromatography‐mass spectrometry (GC‐MS) revealing the presence of some constituents with known tyrosinase inhibitory ability. Most EOs inhibited significantly and dose‐dependently mushroom tyrosinase. Two samples also inhibited the activity of tyrosinase from murine B16 melanoma cells. Our findings indicate that some of the analysed EOs may be promising natural sources for developing novel anti‐melanogenic agents, thus having a good potential in medical, cosmetic and food‐processing industries. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Section: Resultsmentioning

confidence: 52%

Chemical composition and the anti‐melanogenic potential of different essential oils

Fiocco

Arciuli

Arena

et al. 2016

Flavour & Fragrance J

View full text Add to dashboard Cite

show abstract

“…In the presence of UV irradiation, activation of JNK serves as a key kinase in fibroblasts and keratinocytes . It was reported that the JNK pathway participates in regulating melanogenesis . Han et al indicated that JNK activation is highly related to TRP1 protein expression and melanin expression in B16F10 cells.…”

Section: Discussionmentioning

confidence: 99%

Nilotinib induction of melanogenesis via reactive oxygen species‐dependent JNK activation in B16F0 mouse melanoma cells

Chang

Huang

Shen

et al. 2018

Experimental Dermatology

View full text Add to dashboard Cite

Nilotinib (AMN), a second‐generation tyrosine kinase inhibitor, induces apoptosis in various cancer cells, and our recent study showed that AMN effectively reduced the viability of human ovarian cancer cells via mitochondrion‐dependent apoptosis. The effect of AMN in the melanogenesis of melanoma cells is still unclear. In the present study, we found that the addition of AMN but not imatinib (STI) significantly increased the darkness of B16F0 melanoma cells, and the absorptive value increased with the concentration of AMN. A decrease in the viability of B16F0 cells by AMN was detected in a concentration‐dependent manner, accompanied by increased DNA ladders, hypodiploid cells and cleavage of the caspase‐3 protein. An in vitro tyrosinase (TYR) activity assay showed that increased TYR activity by AMN was detected in a concentration‐dependent manner; however, induction of TYR activity by STI at a concentration of 40 μmol/L was observed. Increased intracellular peroxide by AMN was detected in B16F0 cells, and application of the antioxidant, N‐acetylcysteine (NAC), significantly reduced AMN‐induced peroxide production which also reduced the darkness of B16F0 cells. Additionally, AMN induced c‐Jun N‐terminal kinase (JNK) protein phosphorylation in B16F0 cells, which was inhibited by the addition of NAC. AMN‐induced melanogenesis of B16F0 cells was significantly inhibited by the addition of NAC and the JNK inhibitor, SP600125 (SP). Data of Western blotting showed that increased protein levels of melanogenesis‐related enzymes of tyrosinase‐related protein‐1 (TRP1), TRP2 and TYR were observed in AMN‐treated B16F0 cells which were inhibited by the addition of NAC and SP. Evidence is provided supporting AMN effectively inducing the melanogenesis of B16F0 melanoma cells via reactive oxygen species‐dependent JNK activation.

show abstract

“…Cogn .) downregulated the expression levels of p38, CREB, MITF, TYR, TRP1, and TRP2 in a dose‐dependent manner . It was suggested that Achillea millefolium L. EO suppressed melanin production in B16 cell line via reduction of the phosphorylated‐JNK while enhancing the phosphorylated‐ERK without affecting the phosphorylated‐p38 MAPK …”

Section: Depigmenting Compounds and Their Modulation On Melanogenesismentioning

confidence: 99%

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Lajis

Ariff

2019

J of Cosmetic Dermatology

View full text Add to dashboard Cite

Summary Human skin pigmentation is a result of constitutive and facultative pigmentation. Facultative pigmentation is frequently stimulated by UV radiation, pharmacologic drugs, and hormones whereby leads to the development of abnormal skin hyperpigmentation. To date, many state‐of‐art depigmenting compounds have been studied using in vitro model to treat hyperpigmentation problems for cosmetic dermatological applications; little attention has been made to compare the effectiveness of these depigmenting compounds and their mode of actions. In this present article, new and recent depigmenting compounds, their melanogenic pathway targets, and modes of action are reviewed. This article compares the effectiveness of these new depigmenting compounds to modulate several melanogenesis‐regulatory enzymes and proteins such as tyrosinase (TYR), TYR‐related protein‐1 (TRP1), TYR‐related protein‐2 (TRP2), microphthalmia‐associated transcription factor (MITF), extracellular signal—regulated kinase (ERK) and N‐terminal kinases (JNK) and mitogen‐activated protein kinase p38 (p38 MAPK). Other evidences from in vitro assays such as inhibition on melanosomal transfer, proteasomes, nitric oxide, and inflammation‐induced melanogenesis are also highlighted. This article also reviews analytical techniques in different assays performed using in vitro model as well as their advantages and limitations. This article also provides an insight on recent finding and re‐examination of some protocols as well as their effectiveness and reliability in the evaluation of depigmenting compounds. Evidence and support from related patents are also incorporated in this present article to give an overview on current patented technology, latest trends, and intellectual values of some depigmenting compounds and protocols, which are rarely highlighted in the literatures.

show abstract

The Melanogenesis Alteration Effects of Achillea millefolium L. Essential Oil and Linalyl Acetate: Involvement of Oxidative Stress and the JNK and ERK Signaling Pathways in Melanoma Cells

Cited by 68 publications

References 28 publications

Chemical composition and the anti‐melanogenic potential of different essential oils

Chemical composition and the anti‐melanogenic potential of different essential oils

Nilotinib induction of melanogenesis via reactive oxygen species‐dependent JNK activation in B16F0 mouse melanoma cells

Discovery of new depigmenting compounds and their efficacy to treat hyperpigmentation: Evidence from in vitro study

Contact Info

Product

Resources

About