“…We feel, too, that infection plays an important part in some cases, but we have not been impressed by the bone-marrow response to penicillin or chemotherapy. Foy et al (1950) thought that the megaloblastosis might be related to protein deficiency, but later they reported, in separate articles (Foy et al, 1951a(Foy et al, , 1951b, two cases which responded to penicillin alone. Many of our cases were given antibiotics because of some superimposed infection, and, despite this, they developed megaloblastosis.…”