The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease

Hueb, Whady; Soares, Paulo R.; Gersh, Bernard J.; Cesar, Luiz Antônio Machado; Luz, Protásio Lemos da; Puig, Luiz Bóro; Martinez, Eulógio M; Oliveira, Sérgio Almeida de; Ramires, José Antônio Franchini

doi:10.1016/j.jacc.2003.08.065

Cited by 338 publications

(198 citation statements)

References 27 publications

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“…The aim in this study was to assess the clinical evolution of 234 hospitalized patients due to the The participants' characteristics regarding the predominance of male and elderly patients is similar to other studies of cardiac patients (8)(9)(10) . These variables are strongly associated with coronary patients' clinical evolution and mortality due to ACS.…”

Section: Discussionmentioning

confidence: 95%

Clinical evolution of patients hospitalized due to the first episode of Acute Coronary Syndrome

Gil¹,

Dessotte²,

Schmidt

et al. 2012

Rev. Latino-Am. Enfermagem

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AIM: to assess the clinical evolution of patients hospitalized due to the first episode of Acute Coronary Syndrome (ACS) according to its clinical manifestation. METHODS: data were collected from 234 patients, hospitalized between May 2006 and July 2009 due to the first episode of an ACS, by consulting their medical records. RESULTS: 234 patients were hospitalized, 140 (59.8%) due to Acute Myocardial Infarction (AMI). In the group with AMI, 19.3% presented complications, against 12.8% in the group with Unstable Angina (UA) (p=0.19). Angioplasty levels were higher among patients with AMI than with UA (p=0.02) and coronary artery bypass graft surgery was more frequent among UA patients (p=0.03). The majority (227; 97%) survived after the coronary event. Among the seven patients who died during the hospitalization, four had AMI (2.9%) and three UA (3.2%). CONCLUSIONS: A larger number of complications were found among infarction victims and the accomplishment of coronary artery bypass graft surgery differed between the groups.

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Section: Discussionmentioning

confidence: 95%

Clinical evolution of patients hospitalized due to the first episode of Acute Coronary Syndrome

Gil¹,

Dessotte²,

Schmidt

et al. 2012

Rev. Latino-Am. Enfermagem

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“…In some the prognosis on medical treatment was better than in those treated by percutaneous revascularization. (4) In my view, there is insuffi cient published evidence to support the performance of percutaneous intervention (PCI) in patients with chronic stable angina for any reason other than relief of symptoms of angina. The views of some practitioners…”

Section: Symptoms and Prognosis In Coronary Diseasementioning

confidence: 99%

The management of patients with stable coronary syndromes

Commerford

2017

SAHJ

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“…These include the asymptomatic cardiac ischemia pilot (ACIP) 31,32 and the MASS trials. 29,30,33 The ACIP study 31,32 evaluated the effects of medical or revascularization (PTCA or CABGS) treatment strategies in patients with stable angiographic CAD (> = 50% stenosis) with or without angina, myocardial ischemia on ambulatory electrocardiography (AECG), and evidence of ischemia on an exercise treadmill test or pharmaceutical stress perfusion study. In this complex, partly blinded study, the three treatment strategies were angina-guided medical therapy; angina-guided plus AECG ischemiaguided medical therapy; and myocardial revascularization of major coronary arteries.…”

Section: Comparison Of Myocardial Revascularization With Medical Therapymentioning

confidence: 99%

“…31,32 The MASS trial compared the effect of these therapies in patients with proximal-LAD (MASS-1) 29,30 and in patients with multi-vessel CAD (MASS-2). 33 In the Clinical Cardiology DOI:10.1002/clc MASS trials, all patients were placed on an optimal medical regimen that included: nitrates, aspirin, betablockers, CCBs, ACEI, or a combination of these drugs. In addition, a statin along with a low-fat diet was provided on an individual basis.…”

Section: Comparison Of Myocardial Revascularization With Medical Therapymentioning

confidence: 99%

“…In addition, a statin along with a low-fat diet was provided on an individual basis. 29,30,33 In the prospective MASS-1 trial 29,30 in patients with p-LAD involvement (> = 0.80 stenosis) compared to PTCA and medical therapy, CABGS was associated with a modest benefit on the combined outcome that consisted of cardiac death, MI, or angina requiring revascularization (the benefit was predominantly related to a less frequent need for subsequent revascularization). 29,30 It is important to note that compared to CABGS, medical therapy was associated with a similar reduction in the risk of hard events (mortality or MI).…”

Section: Comparison Of Myocardial Revascularization With Medical Therapymentioning

confidence: 99%

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Trials and tribulations associated with angina and traditional therapeutic approaches

2007

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SummaryIschemic heart disease is the foremost cause of death in the United States and the developed countries. Stable angina is the initial manifestation of ischemic heart disease in one half of the patients and becomes a recurrent symptom in survivors of myocardial infarction (MI) and other forms of acute coronary syndromes (ACS). There are multiple therapeutic modalities currently available for treatment of anginal symptoms in patients with stable CAD. These include anti-anginal drugs and myocardial revascularization procedures such as coronary artery bypass graft surgery (CABGS), percutaneous transluminal coronary angioplasty (PTCA) and percutaneous coronary intervention (PCI). Anti-anginal drug therapy is based on treatment with nitrates, beta blockers, and calcium channel blockers. A newly approved antianginal drug, ranolazine, is undergoing phase III evaluation. Not infrequently, combination therapy is often necessary for adequate symptom control in some patients with stable angina. Howerever, there has not been a systematic evaluation of individual or combination antianginal grug therapy on hard clinical end points in patients with stable angina. Most revascularization trials that have evaluated treatment with CABGS, PTCA, or PCI in patients with chronic CAD and stable angina have not shown significant improvement in survival or decreased incidence of non-fatal MI compared to medical treatment. In the

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The medicine, angioplasty, or surgery study (MASS-II): a randomized, controlled clinical trial of three therapeutic strategies for multivessel coronary artery disease

Cited by 338 publications

References 27 publications

Clinical evolution of patients hospitalized due to the first episode of Acute Coronary Syndrome

Clinical evolution of patients hospitalized due to the first episode of Acute Coronary Syndrome

The management of patients with stable coronary syndromes

Trials and tribulations associated with angina and traditional therapeutic approaches

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