The Medical Supplies Resemblance Ingredient in Health Foods

We developed a method for the identification of 18 illegal adulterants in dietary supplements for erectile dysfunction by using high-performance liquid chromatography-mass spectrometry. The separation was achieved on a Cosmosil 3C 18 -EB column. The mobile phase consisted of 0.1 formic acid solution and 0.1 formic acid in acetonitrile, with gradient elution at a flow rate of 0.15 mL/ min. The proposed method may be useful for the identification of illegal adulterants and for quality control of dietary supplements.

Section: Introductionmentioning

confidence: 99%

“…In recent years, impairment of health owning to ingestion of dietary supplements that contain medicinal ingredients has become a social problem 1) . Since this may be due to the presence of illegal adulterants, it is necessary to analyze commercial dietary supplements to confirm their purity.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Identification of 18 Illegal Adulterants in Dietary Supplements by Using High-Performance Liquid Chromatography-Mass Spectrometry

Tagami

Aoyama

Asada

et al. 2014

“…The known side effects of PDE-5 inhibitors include headaches and visual abnormality. Mortality could also result from the combined use of PDE-5 inhibitors and nitric monoxide donors 1) . Various ingredients whose structures have been modified from those of medicinal ingredients, such as sildenafil, in order to avoid identification have also been detected in dietary supplements…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, adverse effects of dietary supplements that contain medicinal ingredients has become a social problem 1) . To prevent impairment of health by medicinal ingredients present in dietary supplements, it is necessary to analyze the components commercial of dietary supplements.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Identification of Hydroxythiohomosildenafil, Aminotadalafil, Thiosildenafil, Dimethylsildenafil, and Thiodimethylsildenafil in Dietary Supplements Using High-Performance Liquid Chromatography-Mass Spectrometry

貴臣

章弘

安紀子

et al. 2013

We developed a method for the separation and identification of illegal adulterants (hydroxythiohomosildenafil, aminotadalafil, thiosildenafil, dimethylsildenafil, and thiodimethylsildenafil) from dietary supplements using high-performance liquid chromatography-mass spectrometry. The separation was achieved on a C 18 column: the mobile phase consisted of 5 mM ammonium formate (pH 6.3)-acetonitrile (75 : 25, v/v) and acetonitrile, with gradient elution at a flow rate of 0.2 mL/ min. The proposed method could also be used to separate vardenafil, homosildenafil, and dimethylsildenafil, all of which have the same molecular weight. Furthermore, the proposed method could simultaneously separate hydroxythiohomosildenafil, aminotadalafil, thiosildenafil, dimethylsildenafil, thiodimethylsildenafil, vardenafil, and homosildenafil. Thus, this method may be useful to identify medicinal ingredients for erectile dysfunction and their analogs and to control the quality of dietary supplements.

A Study on Detection of Drugs in Slimming Health Foods Using GC-MS/MS

Yamamoto¹,

Sumioka²,

Fujioka³

et al. 2011

The determination of five drugs, fenfluramine (FEN), N-nitrosofenfluramine (NFE), sibutramine (SIB), mazindol (MAZ) and phenolphthalein (PHP), was studied in slimming health foods using GC-MS/MS. These drugs have been detected at high rates, especially in slimming health foods. Prolonged or excessive consumption of non-approved or unauthorized pharmaceuticals may cause serious adverse health consequences. In this study, samples were extracted with methanol and ultrasonication. Analyses were performed by GC-MS/MS, using established MS/ MS parameters in the electron ionization (EI) mode and chemical ionization (CI) mode. In the EI mode, the recoveries of five drugs from several types of slimming health foods such as tablets, capsules and tea-bags spiked at 1 ῌg/mg (except PHP, spiked at 4 ῌg/mg) were in the range of 85.0῍110.7 and 100 ῌg/mg (except PHP, spiked at 200 ῌg/mg) were 94.9῍102.9, respectively. In the CI mode, good recoveries of 80.3῍102.2 (spiked at low concentration) and 92.8῍103.2 (spiked at high concentration) were also obtained. We evaluated the present method using four slimming health foods, in which drugs had previously been detected. The results were similar to the previous results. These findings indicate that the present procedure for evaluating five drugs in slimming health foods by means of GC-MS/MS is useful.