The Medical Research Council and treatments for tuberculosis before streptomycin

Bryder, Linda

doi:10.1177/0141076814548663

J R Soc Med

2014

DOI: 10.1177/0141076814548663

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The Medical Research Council and treatments for tuberculosis before streptomycin

Linda Bryder

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Cited by 5 publications

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“…Thus, the primary treatment remains prevention of transmission and treatment of active cases with anti-tubercular drugs. In Great Britain, the Medical Research Council was established in 1913 with its major focus to tackle TB[22]. Prior to the discovery of anti-TB drugs, surgical techniques like plombage and pneumonectomy were the only medical options available to patients.…”

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confidence: 99%

The History of Tuberculosis: Past, Present, and Future

Prabhu¹,

Singh²

2019

AiM

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Tuberculosis (TB), transmitted by the bacteria Mycobacterium tuberculosis has been a global epidemic for years. The evidence for infection with TB is centuries old. It can have an indolent course, and may remain inactive for years in individuals with the possibility of reactivation at any time, causing widespread systemic symptoms. The treatment and management of TB has become more effective over the years. It is estimated that more than one-third of the world population, especially in poor and developing countries are harboring this bacterium with varying manifestations of the disease from no symptoms to life-threatening infections. This manuscript describes the history of the disease and the discoveries. It also includes the recent advances and challenges facing the world and how governments and organizations are working together to control this disease.

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confidence: 99%

The History of Tuberculosis: Past, Present, and Future

Prabhu¹,

Singh²

2019

AiM

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Treatment of rheumatic musculoskeletal disorders

Buchanan,

Rainsford,

Kean

et al. 2023

Inflammopharmacol

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Unravelling the ‘Tangled Web’: Chemotherapy for Tuberculosis in Britain, 1940–70The William Bynum Prize Essay

Leeming-Latham¹

2015

Med. Hist.

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Abstract:The introduction and assimilation of chemotherapy to treat pulmonary tuberculosis (TB) during the mid-twentieth century appears at first sight to be a success story dominated by the use of streptomycin in a series of randomised clinical trials run under the auspices of the Medical Research Council (MRC). However, what this standard rhetoric overlooks is the complexity of TB chemotherapy, and the relationship between this and two other ways of treating the disease, bed rest and thoracic surgery. During the late 1940s and 1950s, these three treatment strands overlapped one another, and determining best practice from a plethora of prescribing choices was a difficult task. This article focuses on the clinical decision-making underpinning the evolution of successful treatment for TB using drugs alone. Fears over the risk of streptomycin-resistant organisms entering the community meant that, initially, the clinical application of streptomycin was limited. Combining it with other drugs lessened this risk, but even so the potential of chemotherapy as a curative option for TB was not immediately apparent. The MRC ran a series of clinical trials in the post-war period but not all of their recommendations were adopted by clinicians in the field. Rather, a range of different determinants, including the timing of trials, the time taken for results to emerge, and whether these results 'fitted' with individual experience all influenced the translation of trial results into clinical practice.

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The Medical Research Council and treatments for tuberculosis before streptomycin

Cited by 5 publications

References 13 publications

The History of Tuberculosis: Past, Present, and Future

The History of Tuberculosis: Past, Present, and Future

Treatment of rheumatic musculoskeletal disorders

Unravelling the ‘Tangled Web’: Chemotherapy for Tuberculosis in Britain, 1940–70The William Bynum Prize Essay

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