The medical management of inflammatory bowel disease in primary care: the north bristol experience

Arthurs, E A; Gholkar, B; Burley, K; Williams, Lynn; Lockett, M

doi:10.1136/gut.2011.239301.276

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Endoscopy with biopsy remains the most reliable method. 15 16 However, the facts that the endoscopic interventions are invasive and frequently disturbing and that the symptoms are usually not conclusive have led to the use of laboratory investigations in the assessment of disease activity among IBD patients. 17 Among these, acute phase reactants, ESR, CRP, occult blood in stool, and FC are the most frequently used laboratory markers because they are readily available, simple, noninvasive, relatively cheap, and have reported efficacy.…”

Section: Discussionmentioning

confidence: 99%

Can Fecal Calprotectin Reflect Your Colonic Status?

Salama

Ahmed

2022

Journal of Coloproctology

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Background Organic colonic manifestation may be difficult to be differentiated from functional one. Inflammatory bowel disease (IBD) is a common chronic inflammatory and destructive disease of the bowel wall. Chronic inflammation is associated with ulcerations, strictures, perforations, and it is a risk factor for dysplasia and cancer. To reduce these long-standing complications, IBD patients are in a continuous need for early diagnosis1. Markers, such as erythrocyte sedimentation rate (ESR), and c-reactive protein (CRP), fecal calprotectin (FC) have been widely used as noninvasive parameters for IBD monitoring. We aimed, in this current study, to evaluate the value of fecal calprotectin and other noninvasive biomarkers in predicting abnormal histologic findings in patients undergoing colonoscopy.in addition to determine the cutoff value which predict IBD2. Methods The present prospective study included 160 patients with complaint of colicky abdominal pain with frequent diarrhea associated with mucous and infrequent bleeding per rectum for more than 6 months. They presented partial improvement with medication and recurrence once stopping the treatment These patients had been recently diagnosed with IBD at many primary healthcare centers covering the areas of the Kafrelsheikh and Zagazik governorate in the North of Egyptian Nile delta. After complete history, clinical examination, and laboratory investigation, they were referred to the IBD clinic at Kafrelsheikh University Hospital for assessment and ileocolonoscopy with biopsies. Results There was a wide spectrum of age of the studied patients, with mean age 40.12 ± 7.88 (minimum 18 and maximum 56 years). Regarding gender, males represented 87.5% of the studied patients. Forty percent of the patients with colonic manifestation were smokers, 57% preferred a spicy diet, and the majority had low educational level (77.5%). Forty percent had obvious blood in stool, 55% had occult blood, and raised ESR CRP occurred in 32.5% and 50%, respectively. Fecal calprotectin cutoff was > 159, with sensitivity 92.8% and specificity 97.5%. Conclusions: Biomarkers (FC, ESR, CRP) can be used as noninvasive parameters for the early diagnosis and prediction of organic colonic disease. Fecal calprotectin in the IBD group revealed significant area under the curve (AUC) values and cutoff > 159, with sensitivity 92.8% and specificity 97.5%.

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Section: Discussionmentioning

confidence: 99%

Can Fecal Calprotectin Reflect Your Colonic Status?

Salama

Ahmed

2022

Journal of Coloproctology

View full text Add to dashboard Cite

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“…Endoscopy with biopsy remains the most reliable meth-od. 15,16 However, the facts that the endoscopic interventions are invasive and frequently disturbing and that the symptoms are usually not conclusive have led to the use of laboratory investigations in the assessment of disease activity among IBD patients. 17 Among these, acute phase reactants, ESR, CRP, occult blood in stool, and FC are the most frequently used laboratory markers because they are readily available, simple, noninvasive, relatively cheap, and have reported efficacy.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2022

Journal of Coloproctology

View full text Add to dashboard Cite

Background Organic colonic manifestation may be difficult to be differentiated from functional one. Inflammatory bowel disease (IBD) is a common chronic inflammatory and destructive disease of the bowel wall. Chronic inflammation is associated with ulcerations, strictures, perforations, and it is a risk factor for dysplasia and cancer. To reduce these long-standing complications, IBD patients are in a continuous need for early diagnosis 1 . Markers, such as erythrocyte sedimentation rate (ESR), and c-reactive protein (CRP), fecal calprotectin (FC) have been widely used as noninvasive parameters for IBD monitoring. We aimed, in this current study, to evaluate the value of fecal calprotectin and other noninvasive biomarkers in predicting abnormal histologic findings in patients undergoing colonoscopy.in addition to determine the cutoff value which predict IBD 2 . Methods The present prospective study included 160 patients with complaint of colicky abdominal pain with frequent diarrhea associated with mucous and infrequent bleeding per rectum for more than 6 months. They presented partial improvement with medication and recurrence once stopping the treatment These patients had been recently diagnosed with IBD at many primary healthcare centers covering the areas of the Kafrelsheikh and Zagazik governorate in the North of Egyptian Nile delta. After complete history, clinical examination, and laboratory investigation, they were referred to the IBD clinic at Kafrelsheikh University Hospital for assessment and ileocolonoscopy with biopsies. Results There was a wide spectrum of age of the studied patients, with mean age 40.12 AE 7.88 (minimum 18 and maximum 56 years). Regarding gender, males represented 87.5% of the studied patients. Forty percent of the patients with colonic manifestation were smokers, 57% preferred a spicy diet, and the majority had low educational level (77.5%). Forty percent had obvious blood in stool, 55% had occult blood, and raised ESR CRP occurred in 32.5% and 50%, respectively. Fecal calprotectin cutoff was > 159, with sensitivity 92.8% and specificity 97.5%.

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How Valuable are Noninvasive Tests as ‎Indicators of IBD Activity and Severity in ‎the Primary Health Care‎ ‎

Ahmed

Emara

Saeed

et al. 2021

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Results: Seventy-eight (81.2%) patients were ulcerative colitis and 18(18.8%) were Crohn's disease, with mean age was 34.40 and 30.94 years respectively (P 0.380).FC, serum total proteins, ESR and HB level showed statistically significant difference between baseline levels and levels at time of remission. However, platelet count and serum albumin were not statistically different. The mean FC level at the time of diagnosis was 823.61±545.457μg/mg and after remission was 165.18±202.255μg/mg (P 0.000). Conclusion: Markers (FC, ESR, serum total proteins and HB level) can be used as non-invasive markers for monitoring IBD activity and severity in the primary health care centers. Fecal calprotectin correlate with endoscopic disease activity. Furthermore, the initial level of FC is a predictor of early dysplasia in ulcerative colitis patients .

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The medical management of inflammatory bowel disease in primary care: the north bristol experience

Cited by 3 publications

References 2 publications

Can Fecal Calprotectin Reflect Your Colonic Status?

Can Fecal Calprotectin Reflect Your Colonic Status?

Untitled

How Valuable are Noninvasive Tests as ‎Indicators of IBD Activity and Severity in ‎the Primary Health Care‎ ‎

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