How Valuable are Noninvasive Tests as ‎Indicators of IBD Activity and Severity in ‎the Primary Health Care‎ ‎

Ahmed, Mohamed H.; Emara, Mohamed H; Saeed, Eman; Abouelfetouh, Mohamed O; Mahros, Aya Mohammed

doi:10.21608/aeji.2021.53849.1122

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…However, they are not magic, and until more data become available, the use of CRP and other laboratory markers should be seen as an additive tool to clinical observation and physical examination rather than a replacement. [21][22][23][24][25] In conclusion, biomarkers (FC, ESR, CRP) can be used as non-invasive parameters for the early diagnosis and prediction of organic colonic disease. Fecal calprotectin in the IBD group revealed significant AUC value and cutoff > 159, with sensitivity 92.8% and specificity 97.5%.…”

Section: Discussionmentioning

confidence: 99%

Can Fecal Calprotectin Reflect Your Colonic Status?

Salama

Ahmed

2022

Journal of Coloproctology

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Background Organic colonic manifestation may be difficult to be differentiated from functional one. Inflammatory bowel disease (IBD) is a common chronic inflammatory and destructive disease of the bowel wall. Chronic inflammation is associated with ulcerations, strictures, perforations, and it is a risk factor for dysplasia and cancer. To reduce these long-standing complications, IBD patients are in a continuous need for early diagnosis1. Markers, such as erythrocyte sedimentation rate (ESR), and c-reactive protein (CRP), fecal calprotectin (FC) have been widely used as noninvasive parameters for IBD monitoring. We aimed, in this current study, to evaluate the value of fecal calprotectin and other noninvasive biomarkers in predicting abnormal histologic findings in patients undergoing colonoscopy.in addition to determine the cutoff value which predict IBD2. Methods The present prospective study included 160 patients with complaint of colicky abdominal pain with frequent diarrhea associated with mucous and infrequent bleeding per rectum for more than 6 months. They presented partial improvement with medication and recurrence once stopping the treatment These patients had been recently diagnosed with IBD at many primary healthcare centers covering the areas of the Kafrelsheikh and Zagazik governorate in the North of Egyptian Nile delta. After complete history, clinical examination, and laboratory investigation, they were referred to the IBD clinic at Kafrelsheikh University Hospital for assessment and ileocolonoscopy with biopsies. Results There was a wide spectrum of age of the studied patients, with mean age 40.12 ± 7.88 (minimum 18 and maximum 56 years). Regarding gender, males represented 87.5% of the studied patients. Forty percent of the patients with colonic manifestation were smokers, 57% preferred a spicy diet, and the majority had low educational level (77.5%). Forty percent had obvious blood in stool, 55% had occult blood, and raised ESR CRP occurred in 32.5% and 50%, respectively. Fecal calprotectin cutoff was > 159, with sensitivity 92.8% and specificity 97.5%. Conclusions: Biomarkers (FC, ESR, CRP) can be used as noninvasive parameters for the early diagnosis and prediction of organic colonic disease. Fecal calprotectin in the IBD group revealed significant area under the curve (AUC) values and cutoff > 159, with sensitivity 92.8% and specificity 97.5%.

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Section: Discussionmentioning

confidence: 99%

Can Fecal Calprotectin Reflect Your Colonic Status?

Salama

Ahmed

2022

Journal of Coloproctology

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“…Fecal calprotectin is a simple tool for assessment of the intestinal inflammation and its level are correlated with severity of intestinal inflammation [6,7]. Many conditions are associated with increase the level of fecal calprotectin such as IBD and (NSAID) use.…”

Section: Introductionmentioning

confidence: 99%

Fecal Calprotectin in assessing Familial Mediterranean Fever Patients

Mahros,

El Shenawy,

Hussien Ahmed

2023

Afro-Egyptian Journal of Infectious and Endemic Diseases

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Background and study aims: Familial Mediterranean fever (FMF) is an autoinflammatory disease presented by inflammatory attacks. Calprotectin (FC) is a calcium-binding protein that is found mainly in neutrophils, in monocytes and reactive macrophages. It considered a cytokine released from monocytes and neutrophils as a result of tissue trauma and inflammation. This study aimed to investigate fecal calprotectin levels in FMF patients as predictor of disease activity. Patients/Material andMethods: This is a Prospective cross-sectional study. Between May 2020 and May 2022, 158 patients diagnosed with FMF in our outpatient clinic in Kafrelsheikh university hospital after confirmation by PCR and obtaining Medical consent for participation in this study. Blood was collected from a peripheral vein to complete blood picture, ESR, CRP, Amyloid A, Faecal calprotectin. Blood tests were examined by ELISA; the study protocol was approved by the local ethics committee. Results: We enrolled 158 patients among them 102 patients were females, and 56 were males. Largest number of patients was diagnosed at age of twenties. Attacks last in 116 patients for less than 48 hours, while lasting for more than that in 42 patients. 130 patients had heterozygous mutation(Group 1), 28 patients had homozygous mutations(Group 2) confirmed by PCR . There was a statistically significant difference between the two groups in Fecal calprotectin level at time of diagnosis (P < 0.001616). The level Calprotectin at time of diagnosis of 100 pg/mL had 96.40% sensitivity and 96.60% Specificity. Homozygous mutation had positive correlation with Colchicine dose needed to give response. Calprotectin level have negative correlation with Colchicine dose needed. Conclusion:Our finding suggests that fecal calprotectin can be used to assess the diagnosis and severity of FMF patients. However, future studies are recommended .

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“…There is a significant need for an enhanced technique to direct the site of biopsy because these samples are random, and do not reflect the whole colon. 8 The identification of dysplasia during colonoscopy has been significantly enhanced by advanced endoscopic techniques, such as chromoendoscopy (CE) and narrowband imaging (NBI). 9,10 NBI improves mucosal surface features and vasculature, and provides the greatest contrast between the microvasculature and the adjacent mucosa, relying on the application of sequential green and blue lights.…”

Section: Introductionmentioning

confidence: 99%

Narrow band imaging as a noninvasive tool for evaluation of the severity of inflammation in patients with ulcerative colitis in Kafr-El-Sheikh university, Egypt

Aya Mohammed Mahros,

Eman Mohammad Saied,

Abdel Atty Ibrahem Abdelatty

et al. 2023

J Pak Med Assoc

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Objective: To analyse the effectiveness of narrow-band imaging in determining the severity of inflammation in ulcerative colitis patients in relation to histological activity.Method: The cross-sectional study was conducted at Kafrelsheikh University Hospital, Egypt, from June 2021 to May 2022, and comprised patients regardless of age and gender who had ulcerative colitis and visited the endoscopy unit. After taking detailed history, the patients were subjected to physical examination and laboratory tests which included complete blood count, international normalised ratio, erythrocyte sedimentation rate and faecal calprotectin. Colonoscopy with narrow-band imaging, biopsy and histopathological assessment were done as part of clinical evaluation. Data was analysed using SPSS 20.Result: Of the 100 patients, 55(55%) were male and 45(45%) were females. The overall mean age was 33.72±10.29 years (range: 11-56 years). There were 73(73%) patients who were married, 12(12%) had positive family history and 19(19%) were smokers. Besides, 18(18%) patients received biological therapy. There was significant positive correlation between histopathological and endoscopic scores (p<0.05). Also, there was a significant positive correlation between histopathological score and findings of narrow-band imaging (p<0.05). There were 10(10%) patients who were found to have dysplasia that was not diagnosed with colonoscopy.Conclusion: Narrow-band imaging was found to have a significant correlation with the histologically determined degree of inflammation.Keywords: Narrow-band imaging, Ulcerative colitis, Histological scoring, Smokers, Leukocyte L1 antigen complex, Colonoscopy, Biopsy, Inflammation, Biological therapy.

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How Valuable are Noninvasive Tests as ‎Indicators of IBD Activity and Severity in ‎the Primary Health Care‎ ‎

Cited by 3 publications

References 20 publications

Can Fecal Calprotectin Reflect Your Colonic Status?

Can Fecal Calprotectin Reflect Your Colonic Status?

Fecal Calprotectin in assessing Familial Mediterranean Fever Patients

Narrow band imaging as a noninvasive tool for evaluation of the severity of inflammation in patients with ulcerative colitis in Kafr-El-Sheikh university, Egypt

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