The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China

Ye, Ye; Huang, Dongping; Pan, Dongxiang; Qiu, Xiaoqiang; Lei, Lei; Luo, Xingxi; Li, Jinxiu; Wu, Kaili; Xiao, Suyang; Liu, Shun; Zeng, Xianmin

doi:10.1007/s11356-021-18186-8

Cited by 3 publications

(2 citation statements)

References 57 publications

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“…The 2 researchers read then the remaining 117 full-text articles and excluded 36 more articles, which led to the final inclusion of 81 articles in the qualitative synthesis. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , ...…”

Section: Resultsmentioning

confidence: 99%

“…These 2 definitions were used in only 24 studies. 12 , 13 , 14 , 16 , 21 , 29 , 31 , 37 , 40 , 41 , 42 , 47 , 48 , 50 , 53 , 60 , 61 , 62 , 64 , 68 , 69 , 72 , 74 , 80 Ten studies used a definition of PPH that differentiates the amount of blood loss based on the mode of delivery (≥500 mL within the first 24 hours after vaginal delivery and ≥1000 mL after C-section). The other studies either chose other cutoffs for blood loss or used combined criteria, particularly the need for blood transfusion in addition to the amount of blood loss at delivery for severe PPH ( supplemental Table 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis

et al. 2023

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Background:Postpartum hemorrhage (PPH) is a leading cause of maternal morbi-mortality. While obstetric risk factors are well described, the impact of predelivery hematological and hemostatic biomarkers remains incompletely understood. Aims:In this systematic review, we aimed to summarize the available literature on the association between predelivery hemostatic biomarkers and PPH/severe PPH. Methods: Searching MEDLINE, EMBASE, and CENTRAL from inception to October 2022, we included observational studies on unselected pregnant women without bleeding disorder reporting on PPH and on predelivery hemostatic biomarkers. Two review authors independently performed title, abstract, and full text screening, upon which quantitative syntheses of studies reporting on the same hemostatic biomarker were conducted, calculating mean differences (MD) between women with PPH/severe PPH and controls. Results: Search of databases on October 18th, 2022 yielded 81 articles fitting our inclusion criteria. The heterogeneity between studies was considerable. With regard to PPH in general, the estimated average MD in investigated biomarkers (platelets, fibrinogen, hemoglobin, D-Dimer, aPTT, PT) were not statistically significant. Women who developed severe PPH had lower predelivery platelets than controls (MD = -26.0 G/L; 95%CI -35.8, -16.1), whereas differences in predelivery fibrinogen concentration (MD = -0.31 g/L; 95%CI -0.75, 0.13) and levels of Factor XIII (MD = -0.07 IU/mL; 95%CI -0.17, 0.04) or hemoglobin (-0.25 g/dL; 95%CI -4.36, 3.85) were not statistically significant in women with and without severe PPH. Conclusion: Predelivery platelet counts were on average lower in women with severe PPH compared with controls, suggesting the potential usefulness of this simple biomarker for predicting severe PPH.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis

et al. 2023

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Aflatoxin B1 exposure triggers hepatic lipotoxicity via p53 and perilipin 2 interaction-mediated mitochondria-lipid droplet contacts: An in vitro and in vivo assessment

Che

Huang

Lin

et al. 2023

Journal of Hazardous Materials

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Therapeutic Efficacy of <i>Bacopa monnieri</i> against Aflatoxin B<Sub>1</sub> Induced Toxicity in Rats

Rathour,

Gupte,

Gupta

et al. 2024

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Aflatoxin B1 (AFB1), the most frequently discovered aflatoxin in tainted foods and feed, is considered the most important risk factor. Brahmi (Bacopa monnieri) is a well-known perennial, creeping herb in the Indian Ayurvedic system. Thus, the present study was designed to evaluate the protective efficacy of Brahmi against liver damage induced by Aflatoxin B1. The whole study was conducted in two experiments. The first experiment used phytochemical estimation of BM (Bacopa monnieri). In the second experiment, animals were randomly divided into six groups with six animals in each group. Group 1 served as the control. Group 2 served as per se and received the highest dose of therapy which was 40 mg/kg for 13 days, post orally. Group 3 received AFB1 (200 μg/kg/day) for 13 days, orally Groups 4 to 6 received different doses of Brahmi (20, 30, 40 mg/kg/day PO) for 3 consecutive days after 10 days of exposure to AFB1. All animals were sacrificed after 24 hr of the last treatment. DPPH free radical scavenging activity of the plant was reported in terms of IC50 (45.30 ± 2.52 μg/ml). The presence of flavonoids and protein in the plant was reported in 29.63 ± 1.63 μg Rutin /mg, and 59.72 ± 3.30 μg BSA / mg. Acute studies showed increased lipid peroxidation and a decline in antioxidant status. Alterations in the Liver Function Test (LFT) were also observed. Oral treatment with 20-40 mg/kg Brahmi showed remarkable protection against the toxic effects of Aflatoxin B1. Biochemical results of this study demonstrate that Bacopa monnieri extract possesses protective potential against AFB1-induced hepatotoxicity due to the presence of several bioactive phytochemicals. From this study, we can conclude that treating Bacopa monnieri can protect against AFB1 challenge rats.

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The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi, China

Cited by 3 publications

References 57 publications

Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis

Hemostatic biomarkers associated with postpartum hemorrhage: a systematic review and meta-analysis

Aflatoxin B1 exposure triggers hepatic lipotoxicity via p53 and perilipin 2 interaction-mediated mitochondria-lipid droplet contacts: An in vitro and in vivo assessment

Therapeutic Efficacy of <i>Bacopa monnieri</i> against Aflatoxin B<Sub>1</sub> Induced Toxicity in Rats

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