The medial prefrontal regulation of maternal behavior across postpartum: A triadic model.

Li, Ming

doi:10.1037/rev0000374

Cited by 10 publications

(5 citation statements)

References 223 publications

(421 reference statements)

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“…The mPFC activity in KO dams was significantly lower within PPH 12 and belatedly increased to WT level after PPH 18. Findings from studies using rats propose that the mPFC functions as an executive control system for regulation of maternal behavior (Li 2022 ). Therefore, it will be worthwhile to investigate the possible role of peripartum mPFC activity for transition to maternal maintenance.…”

Section: Resultsmentioning

confidence: 99%

Abnormal maternal behavior in mice lacking phospholipase Cβ1

Kim

Jang

Koh

2022

Animal Cells and Systems

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Motherhood goes through preparation, onset and maintenance phases until the natural weaning. A variety of changes in hormonal/neurohormonal systems and brain circuits are involved in the maternal behavior. Hormones, neuropeptides, and neurotransmitters involved in maternal behavior act via G-protein-coupled receptors, many of which in turn activate plasma membrane enzymes including phospholipase C (PLC) β isoforms. In this study, we examined the effect of PLCβ1 knockout (KO) on maternal behavior. There was little difference between PLCβ1-KO and wild-type (WT) dams in the relative time spent in maternal behavior during the period between 24 h prepartum and 12 h postpartum (−24 h ∼ PPH 12). After PPH 18, however, PLCβ1-KO dams neglected their pups so that they all died in 2–3 days. In the pup retrieval test, latency was not different during the period within PPH 12, but after PPH 18, PLCβ1-KO dams could not finish pup retrieval in a given time. During both periods, FosB expression in the nucleus accumbens (NAcc) of PLCβ1-KO dams was significantly lower than WT, but not different in the medial preoptic area (mPOA). Given that mPOA activity is required for initiation of maternal behavior, and that NAcc is known to be involved in maternal motivation and maintenance of maternal behavior, our results suggest that PLCβ1 signaling is essential for transition from the onset to maintenance phase of maternal behavior.

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Section: Resultsmentioning

confidence: 99%

Abnormal maternal behavior in mice lacking phospholipase Cβ1

Kim

Jang

Koh

2022

Animal Cells and Systems

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“…mPOA projections to the nucleus accumbens (NAcc) and the mesolimbic dopamine reward system are involved in maternal motivation (Lee et al 2000 ; Numan 2006 ; Brunton and Russell 2008 ; Numan and Stolzenberg 2009 ). The medial prefrontal cortex (mPFC) is proposed to function as an executive control system for parental behavior (Li 2022 ), and fMRI studies on human fathers show it as a main cortical network for mentalization (Provenzi et al 2021 ).…”

Section: Resultsmentioning

confidence: 99%

Compensatory enhancement of paternal care in maternally neglected mice family

Jang,

Kim,

Koh

2023

Animal Cells and Systems

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Parental care strategies, ranging from biparental to uniparental, evolve based on factors affecting sexual conflict over care. Plasticity in how parents respond to reduction in each other’s care effort is thus proposed to be important in the evolution of parental care behaviors. Models predict that ‘obligate’ biparental care is stable when a parent responds to reduced partner effort with ‘partial’ compensation, trading-off current and future reproduction. A meta-analysis of experimental studies on biparental birds also revealed partial compensation, supporting coevolution of parental care type and plasticity pattern. However, few studies have addressed this issue across different taxa and different parental care types. In laboratory mice, a female-biased ‘facultative’ biparental species, fathers paired with a competent mother rarely provide care. We show that, when mated with a pup-neglecting mutant mother, fathers increased care effort to ‘fully’ compensate for the lost maternal care in both pup survival rate and total care amount. Pup retrieval latency was significantly shorter, and neural activity in relevant brain regions twice as high, suggesting enhanced motivation. This study with mice not only opens a road to explore the neural correlates of paternal plasticity but will also help understand how behavioral plasticity contributes to adaptive evolution of parental care behaviors.

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“…Multiple neural networks in brain areas, activated by both hormonal and environmental inputs, mediate maternal care/motivation and affective processing (Keyser‐Marcus et al., 2001; Kim & Strathearn, 2016; Lee & Brown, 2002; Lonstein et al., 2015; Numan & Stolzenberg, 2009; Sato et al., 2010; Terkel et al., 1979; Uriarte et al., 2020) as well as maternal aggression (Bosch & Neumann et al., 2010; Gammie, 2005; Gammie & Nelson, 2001; Haller, 2018; Hasen & Gammie, 2005, 2006; Kohl et al., 2017). In rodents, the medial preoptic area (MPOA)/bed nucleus of the stria terminalis (BNST) circuits are known to be involved in the onset and expression of maternal behavior and pup‐associated motivation during the early period of lactation (Li et al., 1999, 2022; McHenry et al., 2015; Miceli et al., 1983; Numan, 2007; Numan & Stolzenberg, 2009; Oxley & Fleming, 2000; Petrulis, 2013; Semaan & Kauffman, 2010; Terkel et al., 1979; Tobiansky et al., 2013 for review). Importantly, this core circuit has strong connections with the mesolimbic dopamine system, ventral tegmental area (VTA), nucleus accumbens (NA), and caudate putamen, involved in infant‐related reward processing and motivation (Barrière et al., 2021; Dong & Swanson, 2004; Dumont & Williams, 2004; Jalabert et al., 2009; Kudo et al., 2014; Numan, 2007; Numan & Numan, 1997; Numan & Stolzenberg, 2009; Tobiansky et al., 2013).…”

Section: Discussionmentioning

confidence: 99%

Enhanced maternal behaviors in a mouse model of congenital blindness

Bouguiyoud

Xie

Bronchti

et al. 2023

Developmental Psychobiology

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In mammals, mothering is one of the most important prosocial female behavior to promote survival, proper sensorimotor, and emotional development of the offspring. Different intrinsic and extrinsic factors can initiate and maintain these behaviors, such as hormonal, cerebral, and sensory changes. Infant cues also stimulate multisensory systems and orchestrate complex maternal responsiveness. To understand the maternal behavior driven by complex sensory interactions, it is necessary to comprehend the individual sensory systems by taking out other senses. An excellent model for investigating sensory regulation of maternal behavior is a murine model of congenital blindness, the ZRDBA mice, where both an anophthalmic and sighted mice are generated from the same litter. Therefore, this study aims to assess whether visual inputs are essential to driving maternal behaviors in mice. Maternal behaviors were assessed using three behavioral tests, including the pup retrieval test, the home cage maternal behavior test, and the maternal aggression test. Our results show that blind mothers (1) took less time to retrieve their offspring inside the nest, (2) spent more time nursing and licking their offspring in the second‐ and third‐week postpartum, and (3) exhibited faster aggressive behaviors when exposed to an intruder male, compared to the sighted counterparts. This study provides evidence that congenitally blind mothers show more motivation to retrieve the pups, care, and protection towards their pups than sighted ones, likely due to a phenomenon of sensory compensation.

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The medial prefrontal regulation of maternal behavior across postpartum: A triadic model.

Cited by 10 publications

References 223 publications

Abnormal maternal behavior in mice lacking phospholipase Cβ1

Abnormal maternal behavior in mice lacking phospholipase Cβ1

Compensatory enhancement of paternal care in maternally neglected mice family

Enhanced maternal behaviors in a mouse model of congenital blindness

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