The Medial Extended Amygdala in Male Reproductive Behavior A Node in the Mammalian Social Behavior Network

Newman, Sarah Winans

doi:10.1111/j.1749-6632.1999.tb09271.x

Cited by 1,032 publications

(960 citation statements)

References 97 publications

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“…In quail, steroid-sensitive areas such as the medial part of the bed nucleus striae terminalis and parts of the arcopallium including the nucleus taeniae of the amygdala are also clearly involved as indicated by a number of studies based on targeted electrolytic lesions and on the analysis of c-fos expression [2,29,49,137,140]. This is also clearly the case and documented in more detail in other species such as rodents in which areas such as the parts of the amygdala play a critical role in the integration of chemosensory and hormonal cues mediating mating behavior [99,154,155]. As mentioned before, the work of Everitt and collaborators additionally implicates parts of the basolateral amygdala in the control of ASB in rats [67,68].…”

Section: Anatomical Studiesmentioning

confidence: 87%

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

191

168

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Several studies have suggested dissociations between neural circuits underlying the expression of appetitive (i.e. sexual motivation) and consummatory components (i.e., copulatory behavior) of vertebrate male sexual behavior. The medial preoptic area (mPOA) clearly controls the expression of male copulation but, according to a number of experiments, is not necessarily implicated in the expression of appetitive sexual behavior. In rats for example, lesions to the mPOA eliminate maletypical copulatory behavior but have more subtle or no obvious effects on measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females. They also acquire and perform learned instrumental responses to gain access to females. However, recent lesions studies and measures of the expression of the immediate early gene c-fos demonstrate that, in quail, subregions of the mPOA, in particular of its sexually dimorphic component the medial preoptic nucleus, can be specifically linked with either the expression of appetitive or consummatory sexual behavior. In particular more rostral regions can be linked to appetitive components while more caudal regions are involved in consummatory behavior. This functional sub-region variation is associated with neurochemical and hodological specializations (i.e. differences in chemical phenotype of the cells or in their connectivity), especially those related to the actions of androgens in relation to the activation of male sexual behavior, that are also present in rodents and other species. It could thus reflect general principles about POA organization and function in the vertebrate brain.

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Section: Anatomical Studiesmentioning

confidence: 87%

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

191

168

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“…The feeding behavior of homeostatically challenged, food-deprived rats having a self-selection macronutrient diet is the resultant of serial and parallel neural connections needed for processing multiple sensorial information, metabolic/hormonal internal demands, and organization of behavioral displays (Schoenfeld and Hamilton, 1981;Newman, 1999;Berthoud, 2002). However, the influence of the MePD upon different hypothalamic nuclei that control neuroendocrine secretion or behavior display is far from simple.…”

Section: Discussionmentioning

confidence: 99%

“…Based on cytoarchitectual, hodological, and functional criteria, the MeA was divided into the anterodorsal (MeAD), the anteroventral (MeAV), the MePD, and the posteroventral (MePV) subnuclei (Newman, 1999;Petrovich et al, 2001;de Olmos et al, 2004;Dall'Oglio et al, 2008). Taste and visceral sensory information can reach the MeA coming from the pontine parabrachial nucleus (Berthoud, 2002;Knapska et al, 2007).…”

mentioning

confidence: 99%

“…However, no other MeA subnuclei than the MePD appear to be involved with feeding behavior in rats (Stanley et al, 1993;Rollins and King, 2000). It participates in the interpretation of olfactory/vomeronasal information and remarkable projections leave this subnucleus via the ST to reach the hypothalamic ventromedial nucleus, the anteroventral periventricular nucleus, the preoptic area, and the ventral premammillary nucleus in the hypothalamus (Newman, 1999;Dong et al, 2001;Petrovich et al, 2001). These hypothalamic nuclei considerably affect food intake and energy balance (Hill et al, 2008).…”

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confidence: 99%

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Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Rosa¹,

Goularte²,

Trindade³

et al. 2011

The Anatomical Record

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Previous studies have involved the ''posterodorsal'' amygdaloid area with the control of food intake and the development of obesity in rats. Within this wide region, the posterodorsal medial amygdala (MePD) has connections with specific hypothalamic nuclei that increase feeding behavior and modulate energy balance. Glutamate is the major brain excitatory neurotransmitter, remarkably enhances centrally mediated food consumption, and is abundantly found in the MePD. Here, it was studied the effects of saline (0.3 lL) and glutamate (45 nM or 45 mM/0.3 lL) directly microinjected in the MePD of adult male rats on the consumption of a three-choice (high-carbohydrate, high-protein, or high-lipid) macronutrient selective diet. The rat adaptation to the experimental procedures and its body weight gain were continuously evaluated. Control data for all groups and results following microinjections were obtained after a fasting protocol. Feeding behavior was evaluated during the subsequent 2-hr period of free access to the selective diets. Both doses of glutamate microinjected in the MePD did not lead to a higher percentage of animals consuming any of the different diets (P > 0.05), although glutamate 45 mM induced a higher consumption of the high-carbohydrate diet when compared with presurgery control values (P < 0.01). Interestingly, present data indicate that glutamate in the male MePD induces only a subtle modification in the feeding behavior and suggest that large electrolytic lesions of the ''posterodorsal'' amygdaloid region might have affected other regions to alter drastically meal size consumption in rats. Anat Rec, 294:1226Rec, 294: -1232Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

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“…The expression of immediate early genes, such as c-fos, has been widely used to identify brain regions involved in the control of sexual behavior, including those composing the "social behavior network" (Goodson, 2005;Newman, 1999). For example, c-fos expression is enhanced in the POA and AMY of male rodents, quail and house sparrows following exposure to a sexual stimulus and/or reproductive behavior (Heeb and Yahr, 1996;Pfaus and Heeb, 1997;Riters et al, 2004;Taziaux et al, 2006).…”

Section: Relationship To Other Speciesmentioning

confidence: 99%

Effects of season, testosterone and female exposure on c-fos expression in the preoptic area and amygdala of male green anoles

Neal

Wade

2007

Brain Research

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Expression of the immediate early gene, c-fos, was used to investigate changes in neuronal activity in forebrain regions involved in male sexual behavior following social, hormonal and/or seasonal manipulations in the male green anole. These factors all influence behavior, yet it is unclear how they interact to modify neuronal activity in forebrain regions, including the preoptic area (POA) and ventromedial nucleus of the amygdala (AMY). These regions are involved in the display of sexual behaviors in male green anoles as in many other vertebrates. To determine the effects of seasonal, hormonal and social cues on these brain areas, we investigated c-fos under environmental conditions typical of the breeding or non-breeding season in adult male green anoles that were castrated and implanted with either testosterone (T) or blank (Bl) capsules. We also manipulated social cues by exposing only half of the animals in each group to females. T enhanced courtship and copulatory behaviors, but decreased c-fos expression in the AMY. A similar, although not statistically significant, pattern was observed in the POA, and the density of c-fos+ cells was negatively correlated in that region with the number of extensions of a throat fan (dewlap) used during courtship. Therefore, it appears that in the male green anole, T may diminish c-fos expression (likely in inhibitory neurons) in the POA and AMY to create a permissive environment in which the appropriate behavioral response can be displayed.

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The Medial Extended Amygdala in Male Reproductive Behavior A Node in the Mammalian Social Behavior Network

Cited by 1,032 publications

References 97 publications

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Glutamate Microinjected in the Posterodorsal Medial Amygdala Induces Subtle Increase in the Consumption of a Three‐Choice Macronutrient Self‐Selection Diet in Male Rats

Effects of season, testosterone and female exposure on c-fos expression in the preoptic area and amygdala of male green anoles

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