ResumoEsta pesquisa observacional do tipo estudo de caso descritivo teve o objetivo de avaliar a resiliência de cuidadores de idosos demenciados com Alzheimer. Como instrumento, utilizou-se questionário para traçar o perfil do cuidador; protocolo bipolar para avaliar o estado subjetivo de fadiga; o SRQ -Self Report Questionnaire para avaliação do estresse; o inventário de Zarit para a sobrecarga e protocolo para a resiliência dos seis cuidadores que participaram do estudo. As variáveis quantitativas foram descritas em função de sua média e variância. Para as associações, utilizaram-se Correlação de Pearson e o Teste do Chi-Quadrado. O nível de significância adotado foi de p < 0,05. Os resultados indicaram que 83,3% dos cuidadores são femininos e 16,7%, masculinos; sendo quatro (66,7%) filhos e dois (33,3%) cônjuges. Observou-se que o estado de saúde de quatro cuidadores piorou, passando de um estado regular para ruim, em um período de cinco anos. Um (16,7%) cuidador dedica 20 horas do seu tempo ao cuidado e, para os demais (83,3%), a exigência é de 24 horas. Dos seis cuidadores, quatro demonstram probabilidade de desenvolver transtornos psiquiátricos e dois, não. E ainda, 66,7% dos cuidadores não apresentam sobrecarga, enquanto 33,3% acham-se com sobrecarga intensa. Embora alguns se mostrem fatigados e sobrecarregados, a maioria (83,3%) demonstra alta disposição à resiliência. Houve associação significativa entre resiliência e idade (p< 0,050), a qual expressa quanto maior a idade do cuidador maior a resiliência. AbstractThis observational study of the descriptive case study type aimed to evaluate the resilience of caregivers of demented elderly people with Alzheimer. A questionnaire was used to trace the profile of the caregivers; bipolar protocol to evaluate the fatigue subjective state; the SRQ -Self Report Questionnaire to evaluate the stress; the Zarit inventory to evaluate overload and protocol to evaluate resilience of the six caregivers Palavras-chave: Cuidadores. Demência. Fadiga. Resiliência Psicológica.

Previous studies have involved the ''posterodorsal'' amygdaloid area with the control of food intake and the development of obesity in rats. Within this wide region, the posterodorsal medial amygdala (MePD) has connections with specific hypothalamic nuclei that increase feeding behavior and modulate energy balance. Glutamate is the major brain excitatory neurotransmitter, remarkably enhances centrally mediated food consumption, and is abundantly found in the MePD. Here, it was studied the effects of saline (0.3 lL) and glutamate (45 nM or 45 mM/0.3 lL) directly microinjected in the MePD of adult male rats on the consumption of a three-choice (high-carbohydrate, high-protein, or high-lipid) macronutrient selective diet. The rat adaptation to the experimental procedures and its body weight gain were continuously evaluated. Control data for all groups and results following microinjections were obtained after a fasting protocol. Feeding behavior was evaluated during the subsequent 2-hr period of free access to the selective diets. Both doses of glutamate microinjected in the MePD did not lead to a higher percentage of animals consuming any of the different diets (P > 0.05), although glutamate 45 mM induced a higher consumption of the high-carbohydrate diet when compared with presurgery control values (P < 0.01). Interestingly, present data indicate that glutamate in the male MePD induces only a subtle modification in the feeding behavior and suggest that large electrolytic lesions of the ''posterodorsal'' amygdaloid region might have affected other regions to alter drastically meal size consumption in rats. Anat Rec, 294:1226Rec, 294: -1232Rec, 294: , 2011. V V C 2011 Wiley-Liss, Inc.

Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. . A maioria dos participantes era do sexo feminino (62,5%), tinha síndrome metabólica (61,2%), e sobrepeso/ obesidade (59%). Ao analisar a associação do estado nutricional com síndrome metabólica e seus componentes, encontrou-se associação significativa de obesidade com síndrome metabólica, obesidade central, hipertrigliceridemia, e presença de quatro/cinco componentes da síndrome (p<0,001). O componente da síndrome metabólica mais frequente foi pressão arterial elevada (81,3%) e o menos frequente foi hipertrigliceridemia (48,2%). Em relação ao sexo, a frequência de síndrome metabólica foi significativamente maior entre as mulheres (p=0,004; 66,3% versus 52,7%). Conclusões: A frequência de síndrome metabólica e seus componentes e sua associação com o estado nutricional de idosos cadastrados no HiperDia fornece indícios de que síndrome metabólica e estado nutricional também devem ser monitorados através deste sistema. DESCRITORES: síndrome X metabólica; idosos; estado nutricional; índice de massa corporal; atenção primária à saúde. ABSTRACT Aims:To analyze the association of metabolic syndrome and its components with the nutritional status of elderly enrolled in the HiperDia system. Methods: This was a cross-sectional study with a sample of elderly enrolled in the HiperDia of Central Specialty Unit of Municipal Health Department from Cruz Alta, Rio Grande do Sul, whose records contained the information necessary for the study. Metabolic syndrome diagnosis was based on criteria established by the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) and recommended by the Brazilian Society of Cardiology in the I Brazilian Guidelines for Diagnosis and Treatment of Metabolic Syndrome. Nutritional status was assessed by body mass index, according to the classification of II Guidelines on Geriatric Cardiology of the Brazilian Society of Cardiology. In the statistical analysis, the Student t test and the chi-square test were used, with analysis of adjusted residuals. Results: At all 485 seniors met the inclusion criteria and were selected. The sample mean age was 68.9±6.8 years (range 60 to 94 years). Most participants were female (62.5%) had metabolic syndrome (61.2%), and overweight/obesity (59%). When analyzing the association between nutritional status and metabolic syndrome and its components, significant associations of obesity with metabolic syndrome, central obesity, hypertriglyceridemia, and presence of four/five components of the syndrome (p <0.001) were found. The most common metabolic syndrome component was high blood pressure (81.3%), and the less frequent was hypertriglyceridemia (48.2%). Regarding gender, the frequency of metabolic syndrome was significantly higher among women (p=0.004; 66.3% versus 52.7%). Conclusions:The frequency of metabolic syndr...

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Este estudo descritivo observacional objetiva investigar  o nível de resiliência entre mulheres idosas e sua  associação com bem-estar espiritual e apoio social. A população constituiu-se de 241 mulheres. Os instrumentos foram: Questionário para identificação de dados sociodemográficos; Escala de Resiliência; Escala de Apoio Social e Escala de Bem-Estar Espiritual. O grau de correlação entre cada item e sua respectiva dimensão deu-se através de correlação de Spearman. Para associação entre Resiliência, Bem- Estar Espiritual e Apoio Social, utilizou-se  o Qui-Quadrado de Pearson. As análises estatísticas realizaram-se no programa IBM SPSS versão 20. Os resultados indicaram 50,2% das idosas apresentam  um alto bem-estar espiritual; 75,9% demonstraram alto apoio social; 79,7% apresentaram alto nível de resiliência.  Houve uma correlação  positiva entre bem-estar e resiliência e da mesma forma houve relação de dependência entre as Escalas de Resiliência e de Apoio Social. Quando associada a resiliência  com idade não houve  associação  significativa (p< 0, 137). Essas constatações demonstram que embora a vida tenha adversidades, o bem-estar espiritual e o apoio social fortalecem a resiliência.

Introduction: Glioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radiochemotherapy, rising the necessity for searching alternative therapies. Several preclinical studies evaluating the efficacy of cannabinoids in animal models of GBM have been described, but the diversity of experimental conditions and of outcomes hindered definitive conclusions about cannabinoids efficacy. Methods: A search in different databases (Pubmed, Web of Science, Scopus and SciELO) was conducted during June 2019 to systematically identify publications evaluating the effects of cannabinoids in murine xenografts models of GBM. The tumour volume and number of animals were extracted, and a random effects meta-analysis of these results was performed to estimate the efficacy of cannabinoids. The impact of different experimental factors and publication bias on the efficacy of cannabinoids was also assessed. Results: Nine publications, which satisfied the inclusion criteria, were identified and subdivided in 22 studies involving 301 animals. Overall, cannabinoid therapy reduced the fold of increase in tumour volume in animal models of GBM, when compared with untreated controls. The overall weighted standardized difference in means (WSDM) for the effect of cannabinoids was-1.399 (95% CI:-1.900 to-0.898; p-value<0.0001). Furthermore, treatment efficacy was observed for different types of cannabinoids, alone or in combination, and for different treatment durations. Cannabinoid therapy was still effective after correcting for publication bias. Conclusions: The results indicate that cannabinoids reduce the tumour growth in animal models of GBM, even after accounting for publication bias.

Risco de desnutrição e internação hospitalar em idosos atendidos na Atenção Básica Resumo O objetivo deste estudo foi investigar a associação do risco de desnutrição e dos itens isolados da Mini

Introduction: Sarcopenia, often associated with sedentarism, increases the risk of falls in older people, which may contribute to poorer health. Objective: This study sought to verify the impact of sarcopenia, sedentary lifestyle and risk of falls in older people’s health self-perception. Method: This was an observational, descriptive, cross-sectional study with a quantitative approach. The sample included 317 older people from the municipality of Cruz Alta, who underwent an assessment with specific instruments to evaluate the presence of risk of falls (Downton and Timed Up and Go - TUG) and sarcopenia (Manual Hold Force - MHF and Circumference of the Calf - CP). They were also subjected to the International Physical Activity (IPAQ) and the Self-perception of Health questionnaires. Association between variables was performed using the Pearson chi-square test, with a 95% confidence interval (CI). Results: In respect to TUG, 202 (63.7%) older people presented an average risk of falls, and only 27 (8.5%) presented a high risk of falls. However, Downton showed that a hundred older people (31.5%) were at risk of falling. Sarcopenia as evaluated via CP and MHF was observed in 4.7% (15) and 31.9% older people, respectively. Regarding IPAQ, 161 (50.8%) participants were classified as active, while 156 (49.2%) were classified as inactive. In regards to self-perceived health, 159 (50.2%) older people evaluated their health condition as average or poor. Conclusion: Results suggest that older people’s negative health self-perception is directly associated with predisposing factors for falls, such as sarcopenia and physical inactivity, as well as the presence of risk of falls (as evaluated by instruments that take into account risk factors and individual physical conditions).