The mechanisms of weight-cutting effect in Pu-erh tea

Zou, Xiaoju; Ding, Yi-Hong; Liang, Bin

doi:10.3724/sp.j.1141.2012.04421

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…At the beginning of the treatment, PTE treatment did not show an effect on lowering body weight. However, PTE reduced OVX-induced body weight gain in rats only after 6 weeks of treatment, suggesting that long-term tea drinking has a positive effect on weight loss, which is consistent with the results of previous studies (Zou et al, 2012). Notably, osteoporosis results from an imbalance related to faster bone resorption than bone formation.…”

Section: Discussionsupporting

confidence: 92%

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

et al. 2017

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Background and Objective: Tea drinking is associated with positive effects on bone health and may protect against osteoporosis, especially in elderly women. Pu-erh tea has many beneficial effects on human health; however, whether Pu-erh tea has anti-osteoporotic potential remains unclear. Thus, we investigated the effects of Pu-erh tea extract (PTE) on ovariectomy-induced osteoporosis in rats and on osteoclastogenesis in vitro.Methods: Female Wistar rats were divided into six groups: the sham, model, and Xian-Ling-Gu-Bao capsule (XLGB) groups, and the low-, medium-, and high-dose PTE groups. Ovariectomized (OVX) rats were used as an animal model of osteoporosis. The animals were intragastrically administered distilled water, XLGB, or different concentrations of PTE for 13 weeks. Body weight, blood biochemical indicators, relative organ coefficients, femoral bone mineral density (BMD), bone biomechanical properties, and bone microarchitecture were examined and analyzed. Additionally, the in vitro effects of PTE on osteoclastic activities were investigated using the RAW 264.7 cell line as an osteoclast differentiation model. The effects of PTE on osteoclast differentiation and the expression of osteoclast-specific genes and proteins were determined.Results: PTE reduced OVX-induced body weight gain after 6 weeks of treatment, and the high-dose exerted a significant effect. High-dose PTE significantly ameliorated OVX-induced estradiol (E2) deficiency. PTE treatment maintained calcium and phosphorus homeostasis and improved other blood biochemical parameters to various degrees. In addition, PTE treatment improved organ coefficients of the femur, uterus, and vagina and improved femoral BMD and bone biomechanical properties. PTE treatment strikingly ameliorated bone microarchitecture. Moreover, in the in vitro studies, osteoclast differentiation using the differentiation cell model was significantly inhibited by PTE without cytotoxic effects. Additionally, PTE efficaciously suppressed the expression of key osteoclast-specific genes and proteins.Conclusion: PTE can ameliorate ovariectomy-induced osteoporosis in rats and suppress osteoclastogenesis in vitro.

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Section: Discussionsupporting

confidence: 92%

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

et al. 2017

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“…Zou et al . () reported that polysaccharides, polyphenols, theabrownin and statins in Puerh tea may downregulate the biosynthesis of fat to reduce body weight and upregulate the oxidation of fat and reduce lipid profiles. In addition, gallic acid was also shown to have an effect on attenuating visceral fat accumulation, cholesterol parameters and weight reduction in an animal model (Kubota et al ., ).…”

Section: Discussionmentioning

confidence: 99%

“…These include polyphenols, theabrownin, statins, tea polysaccharides, tea catechins, caffeine, gallic acid, protein, amino acids, alkaloids, vitamins, carbohydrates, minerals and γ-aminobutyric acid (Duh et al, 2004). Zou et al (2012) reported that polysaccharides, polyphenols, theabrownin and statins in Puerh tea may downregulate the biosynthesis of fat to reduce body weight and upregulate the oxidation of fat and reduce lipid profiles. In addition, gallic acid was also shown to have an effect on attenuating visceral fat accumulation, cholesterol parameters and weight reduction in an animal model (Kubota et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Weight Reduction Effect of Puerh Tea in Male Patients with Metabolic Syndrome

Yang

Chou

Ueng

et al. 2014

Phytotherapy Research

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Puerh tea has been proposed to promote weight loss and favorably modify glucose, insulin and blood lipids. This study tested the effect of daily Puerh tea consumption for 3 months on weight and body mass index (BMI), and select metabolic parameters. The effect of daily Puerh tea intake on weight, BMI and changes in glucose, HbA1c and lipids was evaluated in patients with metabolic syndrome. The patients (N = 70) were randomized into two groups: those taking Puerh tea extract capsule (333 mg Puerh tea extract) three times a day and those taking a placebo tea for 3 months. There was a decrease in body weight of 1.3 kg in the Puerh tea group (p = 0.077) versus 0.23 kg in the placebo arm (p = 0.186). There was also a slight decrease in BMI 0.47 kg/m(2) in the Puerh tea group (p = 0.076) versus 0.09 kg/m(2) in the placebo arm (p = 0.185), suggesting a trend of weight change, but without statistical significance. Subgroup analysis of the male patients demonstrated statistically significant improvements in body weight reduction (p = 0.004) and BMI (p = 0.004). However, the change in other metabolic parameters (cholesterol or triglyceride) or HbA1c was not statistically significant. Intake of Puerh tea for 3 months was associated with a slight reduction in body weight and BMI, especially in the male patients. Therefore, daily Puerh tea consumption may be an alternative choice to modify body weight.

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“…Zou et al. reported that tea polysaccharides and theabrownin may downregulate the biosynthesis of fat to reduce body weight and upregulate the oxidation of fat and reduce lipid profiles. Gallic acid was shown to decrease the body weight and the weights of the liver and adipose tissue in rat models of diet‐induced obesity .…”

Section: Discussionmentioning

confidence: 99%

Comparative proteomic analysis using 2DE‐LC‐MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease

Lin

Zhang

et al. 2015

Electrophoresis

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Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats fed either a normal control diet (NCD), a high fat diet (HFD), or a HFD supplemented with high-dose Fuzhuan brick tea extract (FTE) (HFD + HFTE) were comprehensively compared by quantitative proteomics using 2DE-LC-MS/MS. This is the first study of the effects of tea aqueous extract on the liver proteome of rats suffering from metabolic syndrome. The results showed that 57 proteins displayed more than 1.5-fold differences in at least one of two comparisons of HFD versus NCD and HFD versus HFD + HFTE due to HFD feeding and FTE treatment, respectively. Of them, over 75% of proteins exhibited a similar tendency of expression in the two comparisons, meaning FTE was able to correct HFD effects on rat livers. By function analyses, an extensive list of proteins was involved in sugar and lipid metabolism. Compared with HFD-fed rats, the reduced lipogenesis and enhanced β-oxidation, tricarboxylic acid cycle and respiratory chain in HFD + HFTE-fed rats, which mainly contributed to ameliorate hepatic fat accumulation and associated NAFLD. Additionally, some putative drug targets were also revealed such as COX2, PGAM1, ACACB, FAS, and ECHS1.

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The mechanisms of weight-cutting effect in Pu-erh tea

Cited by 5 publications

References 20 publications

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

Weight Reduction Effect of Puerh Tea in Male Patients with Metabolic Syndrome

Comparative proteomic analysis using 2DE‐LC‐MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease

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