The mechanisms of radiation carcinogenesis

Fry, R.J.M.; Ley, Ronald D.

doi:10.1016/0146-5724(84)90069-4

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…In fact it has been shown that UV radiation causes damage to DNA by the formation of free radicals. [46,47] Consequently it would be preferable to irradiate collagen gels with UV-C first, and only then to add cells.…”

mentioning

confidence: 99%

On the Effects of UV‐C and pH on the Mechanical Behavior, Molecular Conformation and Cell Viability of Collagen‐Based Scaffold for Vascular Tissue Engineering

Achilli

Lagueux

Mantovani

2010

Macromolecular Bioscience

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Collagen-based vascular substitutes represent in VTE a valid alternative for the replacement of diseased small-calibre blood vessels. In this study, collagen gel-based scaffolds were crosslinked combining modulation of pH and UV-C radiation. The effects on the mechanical properties, on the molecular structure and on cell viability and morphology were investigated. The mechanical response increased as a function of pH or UV-C dose and strongly depended on the test speed. Collagen molecular conformation resulted only slightly modified. While cell adhesion was not significantly altered, cell proliferation partially decreased in function of pH and UV-C. These findings suggest that UV-C treated collagen gels can represent an adequate substrate for VTE applications.

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mentioning

confidence: 99%

On the Effects of UV‐C and pH on the Mechanical Behavior, Molecular Conformation and Cell Viability of Collagen‐Based Scaffold for Vascular Tissue Engineering

Achilli

Lagueux

Mantovani

2010

Macromolecular Bioscience

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“…This distinction could in some measure account for the far lower incidence of transformation as compared to chromosone aberrations . However, a plausible explanation is not a guarantee of correctness, and several other mechanisms have been proposed for the transition from a cell damaged by radiation to a transformed cell capable of uncontrolled proliferation (Fry andLey 1984, Hall andHei 1985) .…”

Section: Assessment and Interpretation Of Cellular Damagementioning

confidence: 99%

Interpretation of the Increase in the Frequency of Neoplastic Transformations Observed for Some Ionising Radiations at Low Dose Rates

Sykes

Watt

1989

International Journal of Radiation Biology

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The anomalous increase of transformation frequency with decreasing dose rate observed by Hill et al. (1982, 1984b) for mouse fibroblast cells irradiated with fission neutrons cannot be satisfactorily explained by current models of radiation action. Recently a new model has been proposed which predicts the enhancement of damage with prolongation of irradiation, for equal doses. This is applied to the transformation studies in an attempt to interpret the enhancement observed for some radiations but not for others. Evidence is presented which suggests that repaired double-strand breaks in the DNA of cells which survive are the precursors of transformation. A critical physical factor is the total irradiation time rather than the dose rate. Approximately 1 per cent of repaired surviving cells go on to transform. From the results an explanation emerges of why transformation enhancement at low dose rates is not observed for natural alpha radiation and for photons or electrons, but is observed for fission neutrons and fast iron ions.

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Radioprotection and radiosensitization mechanisms and application

Lin¹

1986

International Journal of Radiation Applications and Instrumenta

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The mechanisms of radiation carcinogenesis

Cited by 4 publications

References 48 publications

On the Effects of UV‐C and pH on the Mechanical Behavior, Molecular Conformation and Cell Viability of Collagen‐Based Scaffold for Vascular Tissue Engineering

On the Effects of UV‐C and pH on the Mechanical Behavior, Molecular Conformation and Cell Viability of Collagen‐Based Scaffold for Vascular Tissue Engineering

Interpretation of the Increase in the Frequency of Neoplastic Transformations Observed for Some Ionising Radiations at Low Dose Rates

Radioprotection and radiosensitization mechanisms and application

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