The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment

Xue, Chen; Gu, Xinyu; Bao, Zhengyi; Su, Yuanshuai; Lü, Juan; Li, Lanjuan

doi:10.3389/fimmu.2022.847728

Cited by 25 publications

(25 citation statements)

References 136 publications

(167 reference statements)

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“…A growing body of literature has long shown that mRNAs, miRNAs, lncRNAs, and circRNAs can be used as diagnostic and prognostic biomarkers for certain cancers [23,24,25,26,27,28]. Genetic signature-based risk models have also been widely reported to show high prognostic accuracy in many other cancer types [29,30,31,32].…”

Section: Discussionmentioning

confidence: 99%

Identification of a cuproptosis related chromatin regulators signature for lung adenocarcinoma

Wei

Yang

et al. 2022

Preprint

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Background: Lung adenocarcinoma (LUAD) is the leading cause of cancer-related mortality worldwide, displaying dismal prognosis. Growing evidence now links cuproptosis related genes (CRGs) and chromatin regulators (CRs) to cancer progression. However, the relationship between CRGs and CRs is not yet fully understood. Therefore, we aimed to reveal the connection and prognostic value of these two factors in LUAD patients. Methods: Cuproptosis related genes (CRGs) and chromatin regulators (CRs) were retrieved from previous top studies. For TCGA analysis, mRNA expression andclinical information for LUAD were downloaded via R package. Functional enrichment was analyzed through the ClusterProfler package. Cox regression analysis and LASSO regression analysis were utilized to train models for predicting outcome in LUAD. The Kaplan-Meier curve analyses was used to assess the prognosis for cases categorized as High-risk and Low-risk groups. DsigDB dataset was performed to screen the potential drugs for LUAD treatment. Results: We visualized an protein-protein interaction (PPI) network between CRGs and CRs. Functional analysis suggested that CRs were mainly enriched in chromatin modification and cell cycle pathways. The prognosis prediction model was successfully constructed and validated for the patients with LUAD. Moreover, we also showed 11-CRs-based model was an independent prognostic factor for LUAD patients. This CR-based model was associated with immune cells infiltration as well as immune checkpoint. Seven prospective drugs was detected for the treatment of LUAD patients. Conclusion: In conclusion, our findings provide unique information not available in previous studies, casting novel insights about the correlation between CRGs and CRs in LUAD. We also identified several prognostic biomarkers for the survival of patients with LUAD.

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Section: Discussionmentioning

confidence: 99%

Identification of a cuproptosis related chromatin regulators signature for lung adenocarcinoma

Wei

Yang

et al. 2022

Preprint

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“…The deterioration of cancers relies on the recruitment and reprogramming of tumor cells to the surrounding normal cells ( 130 ). Therefore, in the TME, the crosstalk between tumor cells, immune cells, normal cells, extracellular matrix and various signaling molecules becomes a critical factor ( 9 , 131 , 132 ). As mentioned above, most circRNAs have aberrant expression levels in diverse DSCs, and these dysregulations are caused by different mechanisms.…”

Section: Functional Mechanisms Of Circrnas In the Tmementioning

confidence: 99%

“…In recent years, numerous studies have reported that the tumor microenvironment (TME) plays a critical role in the genesis and development of digestive tumors (5)(6)(7)(8). The TME represents the immediate ecological environment for tumor growth and is composed of multiple cell types that collectively participate in complex regulation (9,10). These cellular interactions are conducive to tumor progression, immune escape, angiogenesis, and metastasis (11), and play crucial roles in the chemoresistance of cancer.…”

Section: Introductionmentioning

confidence: 99%

“…CircRNAs mainly participate in and regulate the progression of DSC by influencing immune cells, energy metabolism, signal transduction, angiogenesis, and lymphatic duct formation in the TME ( 18 , 21 , 22 ). In addition, numerous studies have shown that circRNAs play a key role in human DSCs as diagnostic markers, prognostic targets, and therapeutic targets ( 9 , 23 – 26 ).…”

Section: Introductionmentioning

confidence: 99%

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Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Zhang

et al. 2022

Front. Immunol.

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Circular RNAs (circRNAs) are a new series of noncoding RNAs (ncRNAs) that have been reported to be expressed in eukaryotic cells and have a variety of biological functions in the regulation of cancer pathogenesis and progression. The TME, as a microscopic ecological environment, consists of a variety of cells, including tumor cells, immune cells and other normal cells, ECM and a large number of signaling molecules. The crosstalk between circRNAs and the TME plays a complicated role in affecting the malignant behaviors of digestive system cancers. Herein, we summarize the mechanisms underlying aberrant circRNA expression in the TME of the digestive system cancers, including immune surveillance, angiogenesis, EMT, and ECM remodelling. The regulation of the TME by circRNA is expected to be a new therapeutic method.

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“…Non-coding RNA (ncRNA) refers to RNA molecules transcribed from the genome which do not code for protein, including miRNA, LncRNA, and CircRNA [ 17 ]. NcRNA is widely involved in development and differentiation, reproduction, apoptosis, and cellular reprogramming in biological organisms, and its expression has been found to be closely associated with human disease states [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

Meng

Yuan

et al. 2023

Cell Div

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Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of biological functions in human cells. The Wnt signaling pathway is highly conserved in multicellular organisms, playing an important role in their growth and development. Increasing evidence suggests that ncRNA can regulate cell biological function, enhance bone metabolism, and maintain normal bone homeostasis by interacting with the Wnt pathway. Studies have also demonstrated that the association of ncRNA with the Wnt pathway may be a potential biomarker for the diagnosis, evaluation of prognosis, and treatment of osteoporosis. The interaction of ncRNA with Wnt also performs an important regulatory role in the occurrence and development of osteoporosis. Targeted therapy of the ncRNA/Wnt axis may ultimately be the preferred choice for the treatment of osteoporosis in the future. The current article reviews the mechanism of the ncRNA/Wnt axis in osteoporosis and reveals the relationship between ncRNA and Wnt, thereby exploring novel molecular targets for the treatment of osteoporosis and providing theoretical scientific guidance for its clinical treatment.

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The Mechanism Underlying the ncRNA Dysregulation Pattern in Hepatocellular Carcinoma and Its Tumor Microenvironment

Cited by 25 publications

References 136 publications

Identification of a cuproptosis related chromatin regulators signature for lung adenocarcinoma

Identification of a cuproptosis related chromatin regulators signature for lung adenocarcinoma

Mechanism underlying circRNA dysregulation in the TME of digestive system cancer

Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

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