Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

Abstract

Non-coding RNA (ncRNA) is a type of non-protein-coding RNA molecule transcribed from the genome which performs broad regulation of a variety of biological functions in human cells. The Wnt signaling pathway is highly conserved in multicellular organisms, playing an important role in their growth and development. Increasing evidence suggests that ncRNA can regulate cell biological function, enhance bone metabolism, and maintain normal bone homeostasis by interacting with the Wnt pathway. Studies have also demonstrated that the association of ncRNA with the Wnt pathway may be a potential biomarker for the diagnosis, evaluation of prognosis, and treatment of osteoporosis. The interaction of ncRNA with Wnt also performs an important regulatory role in the occurrence and development of osteoporosis. Targeted therapy of the ncRNA/Wnt axis may ultimately be the preferred choice for the treatment of osteoporosis in the future. The current article reviews the mechanism of the ncRNA/Wnt axis in osteoporosis and reveals the relationship between ncRNA and Wnt, thereby exploring novel molecular targets for the treatment of osteoporosis and providing theoretical scientific guidance for its clinical treatment.

Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis

“…The β-catenin protein in this pathway effectuates differentiation into OBs by inhibiting the adipogenic differentiation of BMSCs ( Mei et al, 2022 ). Recent studies have focused on non-coding RNAs, including miRNAs, lncRNAs, and circRNAs, of which some regulate OP through the Wnt/β-catenin pathway ( Liu et al, 2021 ; Wang Y. et al, 2022 ; An F. et al, 2023 ). They serve as diagnostic markers for disease and help expand the research on related target genes to further clarify the pathogenesis.…”

A potential function for MicroRNA-124 in normal and pathological bone conditions

“…In recent years, endogenous and exogenous non-coding RNAs (ncRNAs) have been reported to regulate multiple signaling pathways in bone biology [ 13 , 28 , 29 ]. ncRNAs do not code for proteins directly but regulate gene expression at the post-transcriptional level.…”