The mechanism of the cadmium-induced toxicity and cellular response in the liver

Souza-Arroyo, Verónica; Fabián, Jessica J.; Bucio, Leticia; Miranda-Labra, Roxana U.; Gómez–Quiroz, Luis E.; Gutiérrez‐Ruiz, María Concepción

doi:10.1016/j.tox.2022.153339

Cited by 42 publications

(16 citation statements)

References 61 publications

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“…4,15 Moreover, the Cd(II) pollutants cause several health side effects, such as acute disorders, pulmonary edema, chronic disorders, emphysema, itai-itai disease, hepatic dysfunction, hypertension, testicular atrophy, osteomalacia, and renal damage. 13,16 Environmentally, the Cd(II) ions exhibit remarkable inhibition effects on the germination of seeds, root elongation of plants, plant length, and leaf productivity. 17 Moreover, the unacceptable concentrations of Cd(II) cause strong adverse effects on aquatic life and ecosystems, as well as the economic quality of sh.…”

Section: Introductionmentioning

confidence: 99%

Insight into the synergetic, steric and energetic properties of zeolitization and cellulose fiber functionalization of diatomite during the adsorption of Cd(ii): advanced equilibrium studies

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Insight into the synergetic, steric and energetic properties of zeolitization and cellulose fiber functionalization of diatomite during the adsorption of Cd(ii): advanced equilibrium studies

et al. 2023

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“…The binding of the Cd to these proteins actually prevents toxic damage of Cd; however, Cd-bound proteins are released from the liver and transferred to the kidneys via blood circulation. After glomerular filtration and tubular reabsorption, Cd accumulates in the kidneys due to exceeding the Cd binding capacity of kidney Mt proteins, or dissociation of Cd from Mt proteins (5,8,9). Free Cd acts as a reactive oxygen species (ROS) stimulating agent.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

İlhan

Büyükbayram

2023

SDÜ Tıp Fakültesi Dergisi

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Objective Cadmium (Cd) is a very toxic and carcinogenic heavy metal that can cause harmful effects on human health. Toxicity may develop due to Cd exposure, especially in the kidneys. Ankaferd blood stopper (ABS) is a herbal mix that is used for its hemostatic properties in surgery. Also, ABS enhances wound and tissue healing. In this study, we aimed to evaluate the possible ameliorative effects of ABS in Cd-induced renal damage. Material and Methods Thirty-two male rats were randomly divided into 4 groups: control, Cd (cadmium chloride, 2.5 mg/kg single dose, i.p.), ABS (ABS, 1.5 ml/kg single dose i.p.), and Cd+ABS (cadmium chloride, 2.5 mg/kg single dose i.p.- ABS, 1.5 ml/kg single dose i.p.). At the end of the experiment, urea and creatinine levels were analyzed from the rats’ serum. In addition, total oxidant status (TOS), total antioxidant status (TAS) levels, superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity were measured spectrophotometrically from renal tissues. The oxidative stress index (OSI) was calculated from TOS and TAS levels. Also, we evaluated alterations in the mRNA expression of Bcl-2-associated X protein (Bax), B-cell-lymphoma-2 (Bcl-2), silenced information regulator 1 (SIRT1), and p53 in kidney tissue of rats by using the qRT-PCR method. Results In the Cd group, serum urea, creatinine levels, and tissue oxidative stress markers, TOS and OSI were higher while Gpx activity was significantly lower than in the control group. Also, the expression of p53 and in Bax/Bcl2 ratio increased in the Cd group. But, ABS treatment diminished urea, creatinine, TOS, OSI levels, and Bax/Bcl2 ratio, p53 expression in Cd applied group. Conclusion ABS showed protective effects by reducing oxidative stress and mitochondria-mediated apoptosis in acute Cd exposure.

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“…Hungry cattle eat everything and their chances of ingesting objects containing lead are very high (95). It acts similar to calcium in the body and builds up in the kidney, the liver, and other tissues (96,97). Clinically, poisoned cattle typically exhibit indications of malnutrition, emaciation, muscle loss, aberrant fetal development, opaque hair, and moderate anemia and thickening of phalange epiphyses (78,98,99).…”

Section: E Ect Of Lead On Cattlementioning

confidence: 99%

“…Arsenic is frequently found in liquids used to dip and spray animals to control ectoparasites and cause toxicity (123). Arsenic-contaminated drinking water, feeds, vegetables, and grasses being fed to the large number of animals kept by the people severely affects the health of the animals (96). High levels of ingested As may remain in the feces, urine, blood, hair, and tissues of animals that are directly or indirectly consumed by humans.…”

Section: Arsenic (As)mentioning

confidence: 99%

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

Tahir

Alkheraije

2023

Front. Vet. Sci.

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Toxicity with heavy metals has proven to be a significant hazard with several health problems linked to it. Heavy metals bioaccumulate in living organisms, pollute the food chain, and possibly threaten the health of animals. Many industries, fertilizers, traffic, automobile, paint, groundwater, and animal feed are sources of contamination of heavy metals. Few metals, such as aluminum (Al), may be eliminated by the elimination processes, but other metals like lead (Pb), arsenic (As), and cadmium (Ca) accumulate in the body and food chain, leading to chronic toxicity in animals. Even if these metals have no biological purpose, their toxic effects are still present in some form that is damaging to the animal body and its appropriate functioning. Cadmium (Cd) and Pb have negative impacts on a number of physiological and biochemical processes when exposed to sub-lethal doses. The nephrotoxic effects of Pb, As, and Cd are well known, and high amounts of naturally occurring environmental metals as well as occupational populations with high exposures have an adverse relationship between kidney damage and toxic metal exposure. Metal toxicity is determined by the absorbed dosage, the route of exposure, and the duration of exposure, whether acute or chronic. This can lead to numerous disorders and can also result in excessive damage due to oxidative stress generated by free radical production. Heavy metals concentration can be decreased through various procedures including bioremediation, pyrolysis, phytoremediation, rhizofiltration, biochar, and thermal process. This review discusses few heavy metals, their toxicity mechanisms, and their health impacts on cattle with special emphasis on the kidneys.

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The mechanism of the cadmium-induced toxicity and cellular response in the liver

Cited by 42 publications

References 61 publications

Insight into the synergetic, steric and energetic properties of zeolitization and cellulose fiber functionalization of diatomite during the adsorption of Cd(ii): advanced equilibrium studies

Insight into the synergetic, steric and energetic properties of zeolitization and cellulose fiber functionalization of diatomite during the adsorption of Cd(ii): advanced equilibrium studies

Protective Role of Ankaferd Blood Stopper on Cadmium-Induced Acute Nephrotoxicity

A review of important heavy metals toxicity with special emphasis on nephrotoxicity and its management in cattle

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