The Mechanism of Secretion and Absorption of Endolymph in the Vestibular Appartus

Distribution of Endothelin-1-Like Activity in the Vestibule of Normal Guinea Pigs

“…These findings suggest that these cells are in volved in the active transport of endolymph [10], Accord ingly, ET-1 activity of these cells suggests that homeostasis for endolymph fluid and ion balance in the pars superior is maintained by cooperation of the dark cells, the planum semilunatum cells and the transitional cells.…”

Cation Transport and Cochlear Function

“…An additional argument for this role of the tegmentum vasculosum can be derived from its fine structure. Jahnke et al ( 1969) demonstrated a great structural similarity between the tegmentum vasculosum and epitheha involved in cation transport like kidney tubules (Pease, 1955), part of the labyrinthine epithelium (Dohlman, 1965, Kimura, 1969 and the nasal gland of marine birds (Doyle, 1960). In addition, the assumption that phylogenetically the tegmentum vasculosum represents both stria vascularis and Reissner's membrane of the mammalian cochlea, is supported by the high Na + -K + -ATPase activities in both tegmentum vasculosum and stria vascularis as will be shown in Chapter VII.…”

“…From a morpho logical point of view the stria vascularis would be expected to play the most important role in cochlear cation transport. There is a great re semblance between the marginal cells of the stria vascularis and those found in epithelia shown to be involved in the atctive transport of ions, such as the dogfish rectal gland (Bulger, 1963) the salt gland of sea birds (Doyle, 1960, Kommck andKomnick 1963) and the kidney tubules (Pease 1955) In the vestibular part of the labyrinth, areas with similar cells have been demonstrated (Dohlman, 1965, Nakai and Hilding, 1968b, Kimura 1969.…”

Apical Lesions of the Cochlea in Idiopathic Endolymphatic Hydrops and other Disorders: Pathophysiological Implications

“…The second set of experiments is by Dohlman (1965) and Silverstein (1970), showing that perfusion of the perilymphatic space with artificial endolymph produces severe nystagmus. Silverstein also observed that when this perfusate of artificial endolymph is left in the perilymphatic space, the potassium concentra tion gradually reverts to normal (for perilymph) over a period of 2 -3 h as the nystagmus subsides.…”