Distribution of Endothelin-1-Like Activity in the Vestibule of Normal Guinea Pigs

Abstract

Endothelin (ET) has been revealed to be a local hormonal regulator of pressure, fluid, ions and neurotransmitters. In order to investigate the mechanism of homeostasis within the microenvironment of the inner ear, the present study has examined the distribution of ET in the vestibule of normal guinea pigs, by immunohistochemistry using mouse antihuman ET IgGl monoclonal antibody. ET-like activity was identified in the sensory epithelial cells, supporting cells, dark cells, transitional cells, vestibular membrane, semicircular wall cells and vestibular ganglion cells. These findings suggest that ET may play an important role in maintaining homeostasis of the vestibule.

The expression of endothelin type A and B receptors in the lateral wall of the mouse cochlea

“…ET-1 activity was detected in the modiolus, spiral ligament, stria vascularis, spiral prominence, Reissner's membrane, supporting cells of the organ of Corti, and spiral ganglion cells [10]. In the vestibule of normal guinea pigs, ET-like activity was identified in the sensory epithelial cells, supporting cells, dark cells, transitional cells, vestibular membrane, semicircular wall cells and vestibular ganglion cells [11]. ET-1-like activity was identified in the epithelial cells and subepithelial connective tissue of the endolymphatic sac and duct of normal guinea pigs [12].…”

Expression and significance of endothelin 1 in spiral ganglion cells of guinea pig

“…It is the most potent vasoconstrictor. Later studies showed that endothelin 1 is widely distributed in cardiovascular and noncardiovascular system [2,3], and also distributed in endolymphatic sac, vestibule and stria vascularis of inner ear [4][5][6]. All the data suggests that endothelin 1 is involved in a wide variety of biological activities including action to maintain the homeostasis of pressure, fluid and electrolyte balance of inner ear.…”

Distribution and significance of endothelin 1 in guinea pig cochlear lateral wall

“…It has many biological functions and plays a significant role in vasoconstriction and the regulation of fluid volume and ion balance. Endothelin-1-like activity has been demonstrated in the inner ear; 2 , 3 however, the role of endothelin 1 in maintaining cochlear homeostasis is not clear.…”