Distribution and significance of endothelin 1 in guinea pig cochlear lateral wall

Dy, Xu; Yd, Tang; Sx, Liu; Liu, Jing

doi:10.1017/s0022215107005993

Cited by 5 publications

(9 citation statements)

References 11 publications

(14 reference statements)

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“…It is widely distributed throughout the mammalian body in cardiovascular and noncardiovascular tissues, including the nervous system, and is also expressed in the spiral modiolar artery, endolymphatic sac, vestibule, stria vascularis, and spiral ganglion cells [63, 64]. …”

Section: Candidate Genes For Senescence Other Geriatric Diseasesmentioning

confidence: 99%

Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment

Uchida

Sugiura

Nakashima

2014

BioMed Research International

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Age-related hearing impairment (ARHI) is a complex, multifactorial disorder that is attributable to confounding intrinsic and extrinsic factors. The degree of impairment shows substantial variation between individuals, as is also observed in the senescence of other functions. This individual variation would seem to refute the stereotypical view that hearing deterioration with age is inevitable and may indicate that there is ample scope for preventive intervention. Genetic predisposition could account for a sizable proportion of interindividual variation. Over the past decade or so, tremendous progress has been made through research into the genetics of various forms of hearing impairment, including ARHI and our knowledge of the complex mechanisms of auditory function has increased substantially. Here, we give an overview of recent investigations aimed at identifying the genetic risk factors involved in ARHI and of what we currently know about its pathophysiology. This review is divided into the following sections: (i) genes causing monogenic hearing impairment with phenotypic similarities to ARHI; (ii) genes involved in oxidative stress, biologic stress responses, and mitochondrial dysfunction; and (iii) candidate genes for senescence, other geriatric diseases, and neurodegeneration. Progress and prospects in genetic research are discussed.

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Section: Candidate Genes For Senescence Other Geriatric Diseasesmentioning

confidence: 99%

Progress and Prospects in Human Genetic Research into Age-Related Hearing Impairment

Uchida

Sugiura

Nakashima

2014

BioMed Research International

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“…1 It is widely distributed throughout the mammalian body in cardiovascular and noncardiovascular tissues, including the nervous system, 2,3 and is also expressed in the spiral modiolar artery, endolymphatic sac, vestibule, stria vascularis, and spiral ganglion cells. [4][5][6] The distribution provides a fair idea of how endothelin-1 functions in the inner ear. It is advocated that endothelin-1 plays a role in regulating the function of the inner ear as a peptide with mitogenic, antiapoptotic, and neural-transmission effects.…”

Section: Introductionmentioning

confidence: 99%

Endothelin‐1 gene polymorphism in sudden sensorineural hearing loss

et al. 2013

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“…distributed in the cardiovascular and noncardiovascular systems, 7 and also distributed in the endolymphatic sac, vestibule, stria vascularis, and spiral ganglion cells of the inner ear. [8][9][10] This distribution strongly suggests that endothelin-1 must play some meaningful role in the inner ear, but no details are currently known. There have been no previous trials to demonstrate the effect of the endothelin-1 gene (EDN1) polymorphism on hearing impairment.…”

Section: Introductionmentioning

confidence: 99%