The Mechanism of Hypoproteinemia Associated with Giant Hypertrophy of the Gastric Mucosa

Citrin, Yale; Sterling, Kenneth; Halsted, James A.

doi:10.1056/nejm195711072571902

Cited by 222 publications

(52 citation statements)

References 20 publications

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“…Increased catabolism of plasma proteins by leakage into the gastrointestinal tract and subsequent digestion by the intestinal enzymes are frequently the causes of hypoproteinemia (1)(2)(3)(4)(5). The presence of plasma proteins has been demonstrated both in saliva and in the gastric and intestinal juice of normal individuals; therefore, gastrointestinal leakage of plasma proteins may account for a substantial part of their normal degradation (6)(7)(8)(9)(10)(11)(12).…”

mentioning

confidence: 99%

Gamma Globulin Turnover and Intestinal Degradation of Gamma Globulin in the Dog*

Andersen¹,

Glenert²,

Wallevik³

1963

J. Clin. Invest.

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mentioning

confidence: 99%

Gamma Globulin Turnover and Intestinal Degradation of Gamma Globulin in the Dog*

Andersen¹,

Glenert²,

Wallevik³

1963

J. Clin. Invest.

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“…It is supported to some extent by experiments showing that the clinical entities of idiopathic hypoalbuminemia (20,21), giant hypertrophic gastritis (22), sprue (23), regional ileitis, and ulcerative colitis (24,25) are associated with loss of albumin and other serum proteins into the gastrointestinal tract. It locates the breakdown compartment close to the vascular compartment as required by the model (19) and allows for salvage of the albumin hydrolysate by reabsorption from the gut.…”

Section: Discussionmentioning

confidence: 67%

The Role of the Gut in Albumin Catabolism

Franks¹,

Mosser²,

Anstadt³

1963

The Journal of General Physiology

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Ira-albumin metabolic studies were carried out in 5 rabbits before, 3 weeks after, and several months after removal of 70 to 90 per cent of the jejunum and ileum. A sixth animal was studied before and 11 weeks after a sham operation. During postoperative experiments, the animals were found to be in a highly unsteady state with large losses of albumin from the vascular compartment. Despite these losses, the plasma albumin concentration was maintained at a relatively constant level. No decrease in the albumin efflux occurred following nearly complete jejuno-ileectomy. The data suggest that albumin catabolism is a first order process.

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“…Accelerated albumin turnover is by no means confined to Cushing's syndrome. It is seen in thyrotoxicosis (11,14) as well as in the hypoproteinemias associated with proteinuria (8,13,14) and with gastrointestinal protein-wasting syndromes (15)(16)(17)(18). It is not, however, regularly associated with either malnutrition (14,19) or debilitating illness.…”

Section: And Interpretationsmentioning

confidence: 99%

The Effect of Cushing's Syndrome Upon Serum Albumin Metabolism *

Sterling¹

1960

J. Clin. Invest.

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The present investigation of albumin metabolism in Cushing's syndrome employing the I'3'-labeled albumin turnover method (1) was undertaken in view of clinical and experimental evidence of significant effects of steroid hormones upon protein metabolism. Previous reports have described acute effects of large doses of glucocorticoids in human subjects (2-4). The effects of chronic hyperadrenalism were examined in the present work. MATERIAL AND M ETHODS Clinical inaterialThe following four categories of subjects were studied: 1) normal volunteers, 2) physically healthy hospitalized schizophrenic patients, 3) cases of Cushing's syndrome due to adrenal cortical hyperplasia; and 4) a patient with Cushing's syndrome due to exogenous steroids. 1) Normiial volunteers. Thirteen subjects, 10 male, 3 female with ages ranging from 19 to 40 years. 2) Physically healthy hospitalied schizophrcnic patients. Ten subjects, 5 male, 5 female with ages ranging from 17 to 39 years.3) Cushing's syndromiie. Albumin turnover studies were carried out on 4 women during the active stage of clinically typical Cushing's syndrome attributed to bilateral adrenal hyperplasia. Three of the 4 were studied again after therapy and remission. The diagnoses were supported by elevated urinary ketogenic steroids or corticoids (Porter-Silber chromogens). In MWI.W., administration of prednisone was followed by suppression of urinary 17-ketosteroid levels. In the other 3 subjects, intravenous ACTH was followed by an exaggerated rise in plasma corticoids, considered indicative of hyperplasia rather than tumor (5). None of the women exhibited appreciable virilization. All had amenorrhea; the 3 of pre-menopausal age resumed menstruation after therapy.M.W., aged 36, had severe Cushing's syndrome with osteoporosis and collapsed lumbar vertebrae, hypertension, intermittent hypokalemic alkalosis, and increased *

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The Mechanism of Hypoproteinemia Associated with Giant Hypertrophy of the Gastric Mucosa

Cited by 222 publications

References 20 publications

Gamma Globulin Turnover and Intestinal Degradation of Gamma Globulin in the Dog*

Gamma Globulin Turnover and Intestinal Degradation of Gamma Globulin in the Dog*

The Role of the Gut in Albumin Catabolism

The Effect of Cushing's Syndrome Upon Serum Albumin Metabolism *

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