The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder

Zhu, Yuncheng; Jiang, Xu; Ji, Weidong

doi:10.1007/s12264-018-0214-x

Cited by 44 publications

(30 citation statements)

References 56 publications

(54 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When this group of features are taken together, involvement of the cortico-striatal-thalamic-cortical (CSTC) circuit also emerges as a notable pattern. The CSTC is a network widely implicated as vulnerable in ASD, ADHD and OCD [45][46][47][48][49]. Children in this group may represent those with this shared vulnerability pathway cutting across diagnoses.…”

Section: Discussionmentioning

confidence: 99%

Integration of Brain and Behavior Measures for Identification of Data-Driven Groups Cutting Across Children with ASD, ADHD, or OCD

Jacobs

Voineskos

Hawco

et al. 2020

Preprint

View full text Add to dashboard Cite

Autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD) and attentiondeficit/hyperactivity disorder (ADHD) are clinically and biologically heterogeneous neurodevelopmental disorders (NDDs). The objective of the present study was to integrate brain imaging and behavioral measures to identify new brain-behavior subgroups cutting across these disorders. A subset of the data from the Province of Ontario Neurodevelopmental Disorder (POND) Network including participants with different NDDs (aged 6-16 years) that underwent cross-sectional T1-weighted and diffusion-weighted magnetic resonance imaging (MRI) scanning on the same 3T scanner, and behavioral/cognitive assessments was used. Similarity Network Fusion was applied to integrate cortical thickness, subcortical volume, white matter fractional anisotropy (FA), and behavioral measures in 176 children with ASD, ADHD or OCD with complete data that passed quality control. Normalized mutual information (NMI) was used to determine top contributing model features. Bootstrapping, out-of-model outcome measures and supervised machine learning were each used to examine stability and evaluate the new groups. Cortical thickness in socio-emotional and attention/executive networks and inattention symptoms comprised the top ten features driving participant similarity and differences between four transdiagnostic groups. Subcortical volumes (pallidum, nucleus accumbens, thalamus) were also different among groups, although white matter FA showed limited differences. Features driving participant similarity remained stable across resampling, and the new groups showed significantly different scores on everyday adaptive functioning. Our findings open the possibility of studying new data-driven groups that represent children with NDDs more similar to each other than others within their own diagnostic group. Such new groups can be evaluated longitudinally for prognostic utility and could be stratified for clinical trials targeted toward each group's unique brain and behavioral profiles.

show abstract

Section: Discussionmentioning

confidence: 99%

Integration of Brain and Behavior Measures for Identification of Data-Driven Groups Cutting Across Children with ASD, ADHD, or OCD

Jacobs

Voineskos

Hawco

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, interference suppression becomes the core concept in the response inhibition, which is called inhibition of competing distractors or inhibition of competing for automatic response 41 . Emotional setting and shifting involved in Stroop test can solve the assessment of competing for automatic response simply (such as the central dimension of the EST) 42 . In the EST, the POS-C, POC-I, NEG-C and NEG-I words reflect response inhibition and emotional response under different color-emotional word interference, while the NEU words reflect responding baseline only.…”

Section: Discussionmentioning

confidence: 99%

Association between olfactory function and inhibition of emotional competing distractors in major depressive disorder

Wang

Jin

Wang

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

We aimed to investigate the changes of olfaction of major depressive disorder (MDD) before and after medical treatment, and to preliminarily scrutinize the association between the olfactory function and the severity of depressive symptoms, response inhibition, and emotional responding. Forty-eight medicine-naïve MDD patients plus 33 healthy controls (HC) matched on gender, ages, and level of education, were recruited in the test group. The Chinese Smell Identification Test (CSIT), Self-reported Olfactory Scale (SROS), 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Rating Scale (HAMA), and mean reaction time/accuracy rate (ΔMRt) of emotional Stroop test were measured. The patients were assessed before the treatment (baseline) and 3 months after the treatment (follow-up). The data at the baseline level were measured then associated using multiple linear regression stepwise analysis. The MDD patients had lower scores of the CSIT and SROS and longer ΔMRt at baseline level compared to Hc while the ΔMRt of MDD patients remained longer after 3-month treatment (p's < 0.05). At the baseline level, the regression equation including age and ΔMRt of negative word-color congruent (NEG-C), was finally observed as follows: y(CSIT) = 10.676-0.063 × 1-0.002 × 2, [x 1 = the age(y), x 2 = the NEG-C (ms)]. The olfactory function of MDD appears to be correlated negatively with the age and the ΔMRT of negative stimuli before treatment. After the remission of MDD, the olfactory dysfunction was improved, which might be regarded as a responding phenotype of brain function of MDD rather than the emotional responding. Major depressive disorder (MDD) and olfaction disorder (OD) are both chronic diseases that affect human being's life quality 1. A systematic review on ten studies chosen for using the Sniffin' Sticks Test and the 40-item Smell Identification Test assessed to reveal the relationship between depression and OD. Results show that both of the olfactory threshold, olfactory discrimination, and olfactory identification were influenced by depression 2. Furthermore, symptoms of depression worsen with the severity of olfactory loss 3. It was demonstrated that olfactory bulbectomy, as a well-known method, could induce an animal model of depression in animal experiment 4. In depression-related brain areas including hippocampus, frontal cortex and hypothalamus, the turnover of serotonin and dopamine decreases in the olfactory bulbectomized rats 5. Similarly, in human studies, Cory et al. 6 found that patients with depression have decreased activities in the left medial orbitofrontal cortex (OFC) accompanied with the defect of the olfactory identification. However, Zucco et al. 7 argued that the changes mentioned above occur in patients with the MDD only, not with the mild or moderate depressive disorder. In the neural circuits involved in emotional processing 8 , these key structures such as amygdala, hippocampus, anterior cingulate cortex(ACC) and OFC, are the imperative functional regions of the human olfactory map...

show abstract

“…Linehan’s model for BPD ( Lieb et al, 2004 ) postulates that a vulnerability to negative affects underlies evolution of BPD symptoms like a disturbed self-image. The widespread connections of the basal ganglia and the thalamus within the cortico-basal ganglia-thalamo-cortical loop ( Parent and Hazrati, 1995 ) and its role in psychiatric diseases ( Neuner et al, 2014 , Peters et al, 2016 , Zhu et al, 2018 ) are widely acknowledged. Our findings support the notion that the appraisal of SR is not purely ‘top-down’ ( Northoff et al, 2006 ), but also integrates bottom-up processes.…”

Section: Discussionmentioning

confidence: 99%

Altered functional connectivity during evaluation of self-relevance in women with borderline personality disorder

Orth

Zweerings

Ibrahim

et al. 2020

NeuroImage: Clinical

View full text Add to dashboard Cite

Highlights: Appraisal of self-relevance is disturbed in borderline personality disorder (BPD). We introduce the first neuroimaging study about self-relevance processing in BPD. Besides the CMS, the MNS and the SMA are involved in self-relevance processing. Functional connectivity of CMS is altered in BPD during self-relevance evaluations. In BPD, valence affects the functional connectivity during self-relevance ratings.

show abstract

The Mechanism of Cortico-Striato-Thalamo-Cortical Neurocircuitry in Response Inhibition and Emotional Responding in Attention Deficit Hyperactivity Disorder with Comorbid Disruptive Behavior Disorder

Cited by 44 publications

References 56 publications

Integration of Brain and Behavior Measures for Identification of Data-Driven Groups Cutting Across Children with ASD, ADHD, or OCD

Integration of Brain and Behavior Measures for Identification of Data-Driven Groups Cutting Across Children with ASD, ADHD, or OCD

Association between olfactory function and inhibition of emotional competing distractors in major depressive disorder

Altered functional connectivity during evaluation of self-relevance in women with borderline personality disorder

Contact Info

Product

Resources

About