The mechanism of acute silver nitrate toxicity in freshwater rainbow trout (Oncorhynchus mykiss) is inhibition of gill Na+ and Cl−1 transport

Morgan, Ian J.; Henry, Raymond P.; Wood, Chris M.

doi:10.1016/s0166-445x(96)00835-1

Cited by 202 publications

(198 citation statements)

References 36 publications

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“…Apart from the effects on the studied parameters, metals like Ag can also be lethal for fish even in such level (0.05 lg/mL) that may not be toxic for the other metals. High toxicity of Ag to fish associated with ionoregulatory disturbances in fish (Morgan et al 1997) was also in agreement with this study. Generally, Ag is amongst the most toxic heavy metals together with Hg, As and Cu and, these were followed by Cd, Pb and Zn (Heath 1995).…”

Section: Resultssupporting

confidence: 92%

Effects of Metal (Ag, Cd, Cr, Cu, Zn) Exposures on Some Enzymatic and Non-Enzymatic Indicators in the Liver of Oreochromis niloticus

Öner

Atli

Canli

2008

Bull Environ Contam Toxicol

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Freshwater fish Oreochromis niloticus exposed to 0.05 microg/mL of Cu, Cd, Zn, Ag and Cr for up to 30 days. Only Ag, which exceeded environmentally realistic concentrations by a factor of >100 caused fish mortality within this period. Metals increased aspartate transaminase (AST) activity, while they decreased alanine transaminase (ALT) activity, except Cr exposure. Concentrations of free -SH group decreased whereas protein concentrations did not alter following metal exposures. Detectable metal accumulation occurred in the liver of Cd, Cu and Zn exposed fish. This study emphasized that both enzymatic and non-enzymatic mechanisms may be useful in understanding the degree of metal toxicity in fish liver.

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Section: Resultssupporting

confidence: 92%

Effects of Metal (Ag, Cd, Cr, Cu, Zn) Exposures on Some Enzymatic and Non-Enzymatic Indicators in the Liver of Oreochromis niloticus

Öner

Atli

Canli

2008

Bull Environ Contam Toxicol

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“…P. promelas exposed to 30 g/L silver for 30 min had a significant decrease in Na + uptake (Fig. 3), in accordance with the previously characterized mechanism of silver induced Na + /K + ATPase inhibition and subsequent Na + depletion reported for other fishes Morgan et al, 1997Morgan et al, , 2004.…”

Section: Effects Of Ag + On CL − and Na + Uptake In P Promelassupporting

confidence: 91%

Is Cl− protection against silver toxicity due to chemical speciation?

Bielmyer

Brix²,

Grosell

2008

Aquatic Toxicology

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“…ATPase activity in fish in vitro is generally inhibited by heavy metals, whereas in vivo effects are not so clear. Brauner et al (2003) observed that ATPase activity decreased in chronic experiments, which was similar to the results of Morgan et al (1997) in acute experiments. In contrast, our results documented that ATPase activity in tadpoles in vivo was positively correlated with exposure time and concentration, which might be because some compensatory mechanisms were involved in the homeostatic mechanisms (Stagg et al, 1992).…”

Section: Resultssupporting

confidence: 74%