The mechanism of action of a single dose of methylprednisolone on acute inflammation in vivo.

Wiener, Stanley L.; Wiener, Roy S.; Urivetzky, Morton; Shafer, Shulamith H.; Isenberg, Henry D.; C, Janov; Meilman, Edward

doi:10.1172/jci108138

Cited by 49 publications

(18 citation statements)

References 22 publications

(17 reference statements)

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“…On the cellular level these components of the interstitial space could buttress the loose collagen network and limit the extent of necrotic myocyte bundle slippage and infarct expansion. Steroids have been shown to suppress tissue edema in the early hours after inflammation (29,30). These effects are dose dependent and last for only several hours after they are administered (30).…”

Section: Discussionmentioning

confidence: 99%

Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat.

Mannisi¹,

Weisman²,

Bush³

et al. 1987

J. Clin. Invest.

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(4), a second possibility is that steroids lead to a prolonged phase during which "soft" necrotic myocardium thins and dilates. The third possibility is that steroids act solely by promoting the early expansion of freshly necrotic myocardium before collagen deposition begins. Infarct expansion, the thinning and dilatation of freshly infarcted myocardium that begins within the first few hours after transmural infarction,

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Section: Discussionmentioning

confidence: 99%

Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat.

Mannisi¹,

Weisman²,

Bush³

et al. 1987

J. Clin. Invest.

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“…Methylprednisolone acetate has been shown to decrease the local inflammatory response induced by various biomaterials. [15][16][17] Gelatin was dissolved in sterile dd H 2 O and 0.05 mL methylprednisolone acetate (of 40 mg/mL stock solution) was added to the solution to form a 10% gelatin-methylprednisolone acetate solution. This solution was added to the PEGdA and the IPN synthesis methods were then followed as previously described.…”

Section: Ipn Synthesismentioning

confidence: 99%

Tissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate

Zilinski

Kao

2003

J Biomedical Materials Res

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Interpenetrating networks (IPNs) of varying formulations were investigated as candidates for an in situ photopolymerizable drug delivery matrix containing poly(ethylene glycol) diacrylate and gelatin. The anti-inflammatory agent methylprednisolone acetate was loaded into the IPN. Bond strength between the IPN and tissue (i.e., muscle, dermis, skin) was determined by a modified American Society for Testing and Materials peel test at constant peel rate. The IPNs provided adhesion values of up to 5.7N, which were three- to fivefold lower than that of the commercial tissue bioadhesive. The subcutaneous cage implant system was utilized to assess material host response and drug efficacy in vivo. IPN formulations elicited a more intense acute inflammatory response than the empty cage controls. Methylprednisolone acetate loaded within the IPNs lowered the level of inflammatory response to levels that were comparable to the empty cage baseline controls. In conclusion, a methodology was developed to quantify the tissue adhesiveness of an in situ photopolymerized IPN matrix containing anti-inflammatory agents. The efficacy of drug-loaded IPN in affecting the host inflammatory response was demonstrated in vivo.

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“…As a result, most centers use only freshly collected PMNs for clinical granulocyte transfusions. PMN The ability of the stored PMNs to localize at anl inflammatory site was studied in vivo by measuring PMN acctumulation in subcutaneously implanted polyvinyl sponges, as has been previously described (6 The accumulation of stored PMNs in the sponges was determined by measuring the sponge tritium activity. To assess the degree to which plasma radioactivity was contributing to activity in the sponges, plasma prepared from labeled fresh blood was injected into sponge-laden recipient animals and sponge tritium activity measured.…”

Section: Introductionmentioning

confidence: 99%

“…The platelets were washed three times in saline and platelet buttons prepared. A suspension of mononuclear cells was obtained by aspiration of the upper white layer from a Hypaque-Ficoll (6). For determination of tritium activity the sponges were air dried, wrapped in filter paper, and compressed into a pellet with a pelletizer (Parr Instrument Co., Moline, Ill.).…”

Section: Introductionmentioning

confidence: 99%

Neutrophil preservation: the effect of short-term storage on in vivo kinetics.

Price

Dale

1977

J. Clin. Invest.

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A B S T R A C TWith unstored blood, 8.1±+0.9% of the injected neutrophil label was present in the subcutaneous sponges. The accumulated label progressively decreased as cell storage time increased reaching at 72 h 5.1+0.6 and 2.6+0.3% for 4°C and room temperature-stored cells, respectively.The results of this study indicate that 4°C storage of rabbit neutrophils is superior to storage at room temperature. The data suggest that it may be feasible to store neutrophils at least a few days without loss of in vivo functions.

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The mechanism of action of a single dose of methylprednisolone on acute inflammation in vivo.

Cited by 49 publications

References 22 publications

Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat.

Steroid administration after myocardial infarction promotes early infarct expansion. A study in the rat.

Tissue adhesiveness and host response of in situ photopolymerizable interpenetrating networks containing methylprednisolone acetate

Neutrophil preservation: the effect of short-term storage on in vivo kinetics.

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