The mechanism of action of omega-3 fatty acids in secondary prevention post-myocardial infarction

Harrison, Nigel; Abhyankar, Brihad

doi:10.1185/030079904x17956

Cited by 29 publications

(14 citation statements)

References 43 publications

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“…These effects were proven in numerous studies [3,[5][6][7][8][9][10][11]. Antithrombotic effects [1,12,13] and antihypertensive effects [14,15] have also been reported.…”

Section: Introductionmentioning

confidence: 92%

Analysis of long-chain ω-3 fatty acid content in fish-oil supplements

Tatarczyk

Engl

Ciardi

et al. 2007

Wien Klin Wochenschr

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“…These effects were proven in numerous studies [3,[5][6][7][8][9][10][11]. Antithrombotic effects [1,12,13] and antihypertensive effects [14,15] have also been reported.…”

Section: Introductionmentioning

confidence: 92%

Analysis of long-chain ω-3 fatty acid content in fish-oil supplements

Tatarczyk

Engl

Ciardi

et al. 2007

Wien Klin Wochenschr

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“…reduced the risk of sudden cardiac death by 45% and the overall mortality by 20% (Marchioli et al, 2002) and that doses of up to 4 g day À1 doses can be tolerated (reviewed in Harrison and Abhyankar, 2005). Therefore we propose that there is particular scope for the use of dietary DHA and EPA not only to effect proliferation but also in the anti-metastatic treatment of CaP.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are concerns after observations that COX-2 inhibitors increase the risk of cardiovascular events during both the VIGOR and APC trials (reviewed in Krotz et al, 2005;Luo et al, 2005). Unlike the synthetic COX-2 inhibitors, EPA and DHA are associated with a reduced risk of cardiovascular disease and sudden cardiac death (Holub and Holub, 2004;Harrison and Abhyankar, 2005). Trials have shown that the early administration of 1 g day À1 o-3 PUFA supplements , with or without 10 mM AA.…”

Section: Discussionmentioning

confidence: 99%

Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs

et al. 2006

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Epidemiological studies have shown not only a relationship between the intake of dietary lipids and an increased risk of developing metastatic prostate cancer, but also the type of lipid intake that influences the risk of metastatic prostate cancer. The Omega-6 polyunsaturated fatty acid, Arachidonic acid, has been shown to enhance the proliferation of malignant prostate epithelial cells and increase the risk of advanced prostate cancer. However, its role in potentiating the migration of cancer cells is unknown. Here we show that arachidonic acid at concentrations p5 mM is a potent stimulator of malignant epithelial cellular invasion, which is able to restore invasion toward hydrocortisone-deprived adipocyte-free human bone marrow stroma completely. This observed invasion is mediated by the arachidonic acid metabolite prostaglandin E 2 and is inhibited by the Omega-3 poly-unsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid at a ratio of 1 : 2 Omega-3 : Omega-6, and by the COX-2 inhibitor NS-398. These results identify a mechanism by which arachidonic acid may potentiate the risk of metastatic migration and secondary implantation in vivo, a risk which can be reduced with the uptake of Omega-3 poly-unsaturated fatty acids.

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“…3,4 Several mechanisms have been proposed by which FO reduces cardiovascular events, including triglyceride-lowering effects, antiinflammatory effects, antithrombotic effects, and antiarrhythmic effects. 5,6 …”

mentioning

confidence: 99%

Fish Oil Promotes Macrophage Reverse Cholesterol Transport in Mice

Nishimoto

Pellizzon

Aihara

et al. 2009

ATVB

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Objective Fish oil (FO), and specifically omega 3 fatty acids, has favorable effects on cardiovascular outcomes. The aim of this study was to investigate the effects of FO on the process of macrophage reverse cholesterol transport (RCT) in an in vivo mouse model. Methods and Results C57BL/6J mice were fed a FO diet, whereas control mice were fed diets containing alternative sources of fats, soybean oil (SO), and coconut oil (CO) for 4 weeks. Macrophage RCT was assessed by injecting [3H]cholesterol-labeled J774 macrophages intraperitoneally into mice. After 48 hours, tissues were harvested and feces were collected. An increase in the excretion of macrophage-derived [3H]-tracer recovered in fecal neutral sterols for FO-fed mice was observed (273% versus SO and 182% versus CO). FO also decreased [3H]-tracer in hepatic cholesteryl ester compared to SO and CO by 76% and 56%, respectively. To specifically determine the effect of FO on the fate of HDL-derived cholesterol, mice fed FO or SO diets were injected with HDL labeled with [3H]cholesteryl oleate, and the disappearance of [3H]-tracer from blood and its excretion in feces was measured. There was no significant difference in the fractional catabolic rate of [3H]cholesteryl oleate-HDL between the 2 groups. However, there was a 242% increase in the excretion of HDL-derived [3H]-tracer recovered in fecal neutral sterols in FO-fed mice, concordant with significantly increased expression of hepatic Abcg5 and Abcg8 mRNA. Conclusion As measured by this tracer-based assay, FO promoted reverse cholesterol transport, primarily by enhancement of the hepatic excretion of macrophage-derived and HDL-derived cholesterol.

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The mechanism of action of omega-3 fatty acids in secondary prevention post-myocardial infarction

Cited by 29 publications

References 43 publications

Analysis of long-chain ω-3 fatty acid content in fish-oil supplements

Analysis of long-chain ω-3 fatty acid content in fish-oil supplements

Promotion of prostatic metastatic migration towards human bone marrow stoma by Omega 6 and its inhibition by Omega 3 PUFAs

Fish Oil Promotes Macrophage Reverse Cholesterol Transport in Mice

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