The Mechanism of Action of Androgens

Mainwaring, W.I.P.

doi:10.1007/978-3-642-88429-0

Cited by 144 publications

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“…However, testosterone itself is the active hormone in the development of the Wolffian duct and the anabolic responses of skeletal muscle, and other steroids are often involved, e.g. aromatization to oestrogen is necessary for androgen action in the brain (reviewed Mainwaring, 1977). The two forms of intracellularly active androgen, testosterone and Sa-dihydrotestostcronc, arc believed to act via the same androgen receptor (see Fig.…”

Section: Mechanism Of Androgen Action In Human Hair Folliclesmentioning

confidence: 99%

Androgens and human hair growth

Randall

1994

Clinical Endocrinology

158

112

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Section: Mechanism Of Androgen Action In Human Hair Folliclesmentioning

confidence: 99%

Androgens and human hair growth

Randall

1994

Clinical Endocrinology

158

112

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“…Although the biological action of testosterone in many target cells depends on its metabolism, principally to 5 -dihydrotestosterone (Mainwaring 1977), there is little or no evidence that the actions of oestrogens involve a local metabolism beyond that of 17 -hydroxysteroid dehydrogenases (Labrie et al 1997). Booth (1983) reported that minces of prostate and seminal vesicles of mature intact boars more readily converted oestrone to oestradiol-17 than vice versa.…”

Section: Discussionmentioning

confidence: 99%

“…In more physiological terms, it was demonstrated later ( Joshi & Raeside 1973) that oestrogens act synergistically with testosterone on the accessory sex glands and on the sexual behaviour of the boar. Because the action of testosterone depends in such large measure on its further metabolism in target cells (Mainwaring 1977), we wished to determine to what extent the response to an oestrogen might similarly relate to its metabolism in the male reproductive system. The present report describes our initial study in which the aim was to see if oestrogens are metabolised by the seminal vesicles and bulbourethral glands in the domestic pig.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of oestrone and oestradiol-17beta to conjugated steroids by the accessory sex glands of the male pig

Raeside

Christie²,

Renaud³

1999

Journal of Endocrinology

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Oestrogens are secreted in large amounts by boar testes and are known to have a synergistic effect with testosterone on the production of large volumes of seminal plasma. Thus, oestrogens play a role in regulating the large accessory sex glands in the boar. Since testosterone metabolites (e.g. 5 -dihydrotestosterone) account for much of its action in target tissues we have looked at the metabolism of oestrogens in the accessory sex glands of the male pig. Tissues from seminal vesicles and bulbourethral glands of 6-week-old castrate and intact males, and 12-week-old castrate animals, were incubated with 3 H-labelled oestrone and oestradiol-17 . Aliquots of spent culture medium and of methanolic tissue extracts were taken to measure radioactivity, prior to separation of unconjugated and conjugated steroids on Waters C 18 Sep-Pak cartridges. About one-third of the radioactivity appeared as conjugates in the media from both glands with each oestrogen. Subsequently, sulphoconjugated steroids and glucuronidates were recovered in series from C 18 cartridges after solvolysis and enzyme hydrolysis respectively. Furthermore, about one-third of the conjugated fraction in each case remained unhydrolysed after these treatments. In conclusion, it is clear that a study of the actions of oestrogens on these glands must consider the dynamics of metabolism of the oestrogens presented to them by the testes and would include conjugation of steroids by the glands themselves.

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“…In this study we (24), and glucocorticoid receptors (GLUC R) are ubiquitous, reflecting the manifold actions of these hormones (25). We sought to assess whether portions of the vascular bed could also serve as direct target organs for these steroids.…”

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confidence: 99%

“…Generally, 24 Scatchard (31). The X intercept (number of sites) and inverse slope (binding affinity expressed as the dissociation constant, Kd) were calculated from the best-fit line determined by linear regression analysis.…”

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Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids.

Horwitz¹,

Horwitz²

1982

J. Clin. Invest.

227

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A B S T R A C T Sex differences and steroid hormones are known to influence the vascular system as shown by the different incidence of atherosclerosis in men and premenopausal women, or by the increased risk of cardiovascular diseases in women taking birth control pills or men taking estrogens. However, the mechanisms for these effects in vascular tissues are not known. Since steroid actions in target tissues are mediated by receptors, we have looked for cytoplasmic steroid receptor proteins in vascular tissues of dogs. We find specific saturable receptors, sedimenting at 8S on sucrose density gradients for estrogens (measured with [3H] We hypothesize that steroid hormones can have direct effects on vascular tissues mediated by specific receptors present in arterial blood vessel walls.

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The Mechanism of Action of Androgens

Cited by 144 publications

References 0 publications

Androgens and human hair growth

Androgens and human hair growth

Metabolism of oestrone and oestradiol-17beta to conjugated steroids by the accessory sex glands of the male pig

Canine vascular tissues are targets for androgens, estrogens, progestins, and glucocorticoids.

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