Androgens and human hair growth

Randall, Valerie A.

doi:10.1111/j.1365-2265.1994.tb02483.x

Cited by 158 publications

(119 citation statements)

References 128 publications

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“…Interestingly, a horse-shoe shaped area of occipital scalp region is consistently spared in male pattern baldness, suggesting a different end-organ response in these hair follicles to the factor(s) causing baldness in other scalp hair follicles. Although human hair growth is affected by thyroid ( Jackson et al 1972) and glucocorticoid (Stenn et al 1993) hormones, pregnancy (Lynfield 1960), and season (Randall & Ebling 1991), androgens are the most obvious regulators of normal human hair growth (reviewed by Randall 1994) and are a prerequisite for male pattern baldness (Hamilton 1942). Paradoxically, androgens stimulate growth in many body areas such as beard and axilla.…”

Section: Introductionmentioning

confidence: 99%

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Hibberts

Howell²,

Randall³

1998

Journal of Endocrinology

230

154

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Androgens can gradually transform large scalp hair follicles to smaller vellus ones, causing balding. The mechanisms involved are unclear, although androgens are believed to act on the epithelial hair follicle via the mesenchymederived dermal papilla. This study investigates whether the levels and type of androgen receptors in primary lines of cultured dermal papilla cells derived from balding scalp hair follicles differ from those of follicles from non-balding scalp.Androgen receptor content was measured by saturation analysis using the non-metabolisable androgen, [3 H]mibolerone (0·05-10 nM) in a 9-10 point assay. Pubic dermal fibroblasts and Shionogi cells were examined as positive controls. Repetitive assays of Shionogi cells showed good precision in the levels of androgen receptor content (coefficient of variation=3·7%). Specific, high affinity, low capacity androgen receptors were detected in dermal papilla cells from both balding and non-balding follicles. Balding cells contained significantly (P<0·01) greater levels of androgen receptors (B max =0·06 0·01 fmol/10 4 cells (mean ...)) than those from non-balding scalp (0·04 0·001). Competition studies with a range of steroids showed no differences in receptor binding specificity in the two cell types.The higher levels of androgen receptors in cells from balding scalp hair follicles with similar properties to those from non-balding scalp concur with the expectations from their in vivo responses to androgens. This supports the hypothesis that androgens act via the dermal papilla and suggests that cultured dermal papilla cells may offer a model system for studying androgen action in androgenetic alopecia.

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Section: Introductionmentioning

confidence: 99%

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Hibberts

Howell²,

Randall³

1998

Journal of Endocrinology

230

154

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“…One explanation for this is that the papilla cells divide in response to the influence of systemic androgens (7). However, like cell death, cell division is not a phenomenon regularly observed among papilla cells in situ (92,93).…”

Section: Puberty and Vellus To Terminal Follicle Transitionsmentioning

confidence: 99%

“…At that time I believed that the dermal papilla was the principal target cell, and cell adhesion the key switch. There is increasing evidence that the dermal papilla is a hormonal target (7,99) and the regulation of follicle size by hormonal modulation of papilla cell division or cell death is one possibility. However, I remain concerned by the paucity of evidence for cell division and cell death in the papilla in situ.…”

Section: Puberty and Vellus To Terminal Follicle Transitionsmentioning

confidence: 99%

“…Since Hamilton (5) first showed that androgenetic alopecia is androgen dependent, the interaction between hormones and the pilosebaceous unit has 235 been studied in considerable detail (for reviews see (6)(7)(8)(9)). Recent research has also been helped by the fact that individual cellular components of the follicle such as the dermal papilla are directly accessible by cell culture (10)(11)(12)(13)(14)(15)(16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Cellular and developmental aspects of androgenetic alopecia

Jahoda

1998

Experimental Dermatology

178

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The hair follicle is a highly complex system that can be investigated at many levels and from multiple perspectives. However, underlying the cyclic production of all hair fibres are a set of common developmental processes. Many current investigations of androgenetic alopecia concentrate on the direct influences of hormones on hair follicles at the cellular but the paper also tries to point out inherent difficulties in the investigation of androgenetic alopecia and important gaps in current knowledge.

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“…Studies show that the hair follicles of AGA-affected individuals have significantly heightened levels of both DHT and ARs. 10 Upon binding of DHT to the receptors, downstream signalling pathway leads to release of specific mediators from dermal papillae causing anagen phase to end and catagen to begin in untimely manner. Such alterations in hair cycles result from reduced levels of specific factors such as IGF-1, BFGF and VEGF which are necessary to sustain anagen phase.…”

Section: 5mentioning

confidence: 99%

Addressing Androgenetic Alopecia-A Complex Disorder-with a Multilateral Treatment Strategy

Patel¹

2017

MOJBB

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Androgens and human hair growth

Cited by 158 publications

References 128 publications

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp

Cellular and developmental aspects of androgenetic alopecia

Addressing Androgenetic Alopecia-A Complex Disorder-with a Multilateral Treatment Strategy

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