The Measurement of Spray Quality for Pan Coating Processes

Chen, Wei; Chang, Shih‐Ying; Kiang, San; Early, William; Paruchuri, Srinivasa; Desai, Divyakant

doi:10.1007/s12247-008-9022-6

Cited by 23 publications

(16 citation statements)

References 6 publications

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“…The particle size distribution (D90/D10, where D10 and D90 are defined as the particle diameter at 10 and 90% of the cumulative particle size distribution, respectively) in Table I shows that HLF, JSF, and MMF had particles with a more uniform size distribution than those of HSF and JLF, because a lower ratio indicates greater uniformity (Chen et al 2008). The particle size distribution (D90/D10, where D10 and D90 are defined as the particle diameter at 10 and 90% of the cumulative particle size distribution, respectively) in Table I shows that HLF, JSF, and MMF had particles with a more uniform size distribution than those of HSF and JLF, because a lower ratio indicates greater uniformity (Chen et al 2008).…”

Section: Resultsmentioning

confidence: 99%

Functional Properties of Submicron‐Scale Rice Flour Produced by Wet Media Grinding

et al. 2015

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Cereal Chem. 93(1):53-57The digestibility and hydration properties of wet-ground submicron-scale rice flour were compared with those of dry-ground coarser microscale flours. The submicron flour (mean size 0.6 µm) was produced in a wet-media mill with 0.3 mm zirconia beads by continuous 24 h pulverization. The solubility, water absorption index, and swelling power increased as the mean particle size decreased, reaching maximum values in the submicron flour.Starch damage was high in the submicron flour, with the absence of intact starch granules. The digestibility also increased as the particle size decreased, and it was highest in the submicron flour. These results show that wet-ground submicron rice flour has different functional properties from dry-ground coarser flour. The digestibility was more strongly influenced by starch damage and the water absorption index than by the mean particle size.

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Section: Resultsmentioning

confidence: 99%

Functional Properties of Submicron‐Scale Rice Flour Produced by Wet Media Grinding

et al. 2015

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“…Even though a decrease in solution/ suspension viscosity will make the atomization more effective (at the same spray rate) and create smaller droplets (29), a significant increase in tablet bed RH from 26.3% to 39.0% was observed when the solids content of the suspension was decreased, similar to the effect of increasing the spray rate. This observation was likely due to the increase in the amount of water sprayed on the tablet bed with the coating suspension at the lower solids level.…”

Section: Suspension or Polymer Concentrationmentioning

confidence: 91%

“…The rate at which the coating formulation is applied to the tablets influences the bed temperature and, thus, the rate of solvent evaporation. Spray rate, in conjunction with atomization air pressure, has been shown to affect spray characteristics, such as droplet size (22)(23)(24). Larger droplets are more likely to dissolve the outermost region of the tablet, potentially resulting in drug migration into the film coat (25).…”

Section: Spray Ratementioning

confidence: 99%

Influence of Process Parameters on Tablet Bed Microenvironmental Factors During Pan Coating

2013

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Abstract. Recent studies have shown the importance of monitoring microenvironmental conditions (temperature, relative humidity) experienced by the tablet bed during a pan coating process, thereby necessitating the need to understand how various process parameters influence these microenvironmental conditions. The process parameters studied in this work include exhaust air temperature, spray rate, inlet airflow rate, gun-to-bed distance, coating suspension percent solids, and atomization and pattern air pressure. Each of these process parameters was found to have an impact on the tablet bed relative humidity (RH), as measured using PyroButton data logging devices. A higher tablet bed RH was obtained with an increase in spray rate and atomization air pressure and with a decrease in exhaust air temperature, inlet airflow rate, gun-to-bed distance, suspension percent solids, and pattern air pressure. Based on this work, it can be concluded that the tablet bed thermodynamic conditions are a cumulative effect of the various process conditions. A strong correlation between the tablet bed RH and the frequency of tablet coating defect (logo bridging) was established, with increasing RH resulting in a higher percent of logo bridging events.

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“…The rate at which the coating formulation is applied to tablets influences the bed temperature and thus the rate of solvent evaporation. Spray rate, along with atomization air pressure, has been shown to affect spray characteristics such as droplet size and velocity distribution . Larger droplets are more likely to dissolve the outermost region of the tablet and physically mix with the coating material, potentially resulting in drug migration into the film .…”

Section: Coating Process Factorsmentioning

confidence: 99%