The mean platelet volume in patients with essential and white coat hypertension

Çoban, Erkan; Yazicioglu, G.; Avcı, Ali; Akçit, Ferhat

doi:10.1080/09537100500163572

Cited by 69 publications

(50 citation statements)

References 25 publications

(24 reference statements)

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“…7 The literature on the association between MPV and stroke is inconsistent 8,9 and may also relate to the use of different methods to assess MPV and the variable time points used for MPV measurement after stroke onset. 10 Moreover, emerging evidence has shown that known cardiovascular risk factors, such as smoking, 11 diabetes mellitus, 12 obesity 13 and hypertension, 14,15 are associated with MPV. Prehypertension, as defined by the Seventh Joint National Committee, 16 includes those with systolic blood pressure ranging 120-139 mm Hg or diastolic blood pressure ranging 80-89 mm Hg, is identified as a predictor for developing hypertension 17 and a stage where the primary prevention of hypertension is possible.…”

Section: Introductionmentioning

confidence: 99%

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

et al. 2012

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Mean platelet volume (MPV), an indicator of platelet activation, has been shown to be elevated in patients with hypertension. However, data available on the association between MPV level and prehypertension are limited. Prehypertension is also associated with an increase in cardiovascular morbidity and mortality. A cross-sectional study was performed among 80 545 standardized medical checkup participants X18 years in age without hypertension or diabetes in China between April 2009 and May 2010. Blood pressure was categorized as prehypertensive (systolic blood pressure, 120-140 mm Hg and/or diastolic blood pressure, 80 to 90 mm Hg, n ¼ 36 586) and normotensive (systolic blood pressure, o120 mm Hg and diastolic blood pressure, o80 mm Hg, n ¼ 43 959). Mean systolic blood pressure and the prevalence of prehypertension increased significantly with increasing MPV. After adjusting for demographics, body mass index, smoking and serum cholesterol, the odds ratio for prehypertension, when comparing the highest category of MPV (412.0 fl) with the lowest category (o10.1 fl), was 1.08 (95% confidence interval, 1.02-1.13; P for trend ¼ 0.014). This association persisted in separate analysis among men but not among women. In nonparametric models, the positive association between MPV and prehypertension appeared to be present across the full range of MPV, without any threshold effect. Increased MPV is associated with prehypertension in a large sample of Chinese adults that are free of cardiovascular disease and hypertension.

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Section: Introductionmentioning

confidence: 99%

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

et al. 2012

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“…Previous studies have demonstrated that there is a close relationship between MPV and cardiovascular risk factors, such as metabolic syndrome, diabetes mellitus, hypertension and hypercholesterolemia [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction

Yazici

Poyraz²,

Şen³

et al. 2011

CIM

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Relationship between mean platelet volume and le ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction Abstract Purpose: Mean platelet volume (MPV) is an indicator of platelet activation, which is a central process in the pathophysiology of coronary heart disease. Metabolic syndrome (MS) may lead to worsened le ventricular systolic function by causing recurrent thrombotic events and by aggravating systemic in ammation in the course of acute myocardial infarction. e present study was designed to investigate the relationship between MPV and le ventricular systolic function in patients with metabolic syndrome who had rst ST-elevation myocardial infarction.Methods: MPV was measured on admission in 33 patients who had preserved le ventricle systolic function (mean age, 56.9±10.2 years) and in 48 patients who had depressed le ventricle systolic function (mean age, 57.9±10.5 years) with metabolic syndrome and rst ST elevation myocardial infarction. Depressed le ventricle systolic function was de ned as ≤50% ejection fraction value. MPV levels were compared in the two groups.Results: MPV was signi cantly higher in patients with depressed le ventricle systolic function in comparison with patients showing preserved le ventricle systolic function (p=0.02). Logistic regression analysis showed an independent relationship between MPV and deteriorated le ventricular systolic function, even a er adjustment for potential confounders (1.08 (1.04-1.20), CI: 95%, p=0.02).Conclusions: Increased MPV on admission can be associated with degree of le ventricle systolic depression in patients with metabolic syndrome with rst ST-elevation myocardial infarction. MPV may prove to be useful as a prognostic marker in patients with metabolic syndrome and ST elevation MI.

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“…Large platelets express higher levels of prothrombotic substances, thromboxane A2, serotonin, b-thromboglobulin, and procoagulatory surface proteins, such as P-selectin and glycoprotein IIIa. [6,7] Increased MPV is associated with gestational diabetes mellitus, [8] congestive cardiac failure, [9] hypertension, [10] hypercholesterolemia, [11] and smoking. [12] Therefore, we excluded all patients having and of the above mentioned diseases to reduce the confounding effect in our statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

et al. 2012

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ÖZET Amaç Bu retrospektif çalışmanın amacı, ortalama tombosit hacmini, akut derin ven trombozlu (DVT) hastalarda ve kontrol grubunda karşılaş-tırmaktır. Gereç ve Yöntem SUMMARY ObjectivesThe purpose of this retrospective study was to compare the mean platelet volume between the patients with acute deep vein thrombosis (DVT) and control subjects. MethodsData were collected retrospectively from the patients' medical records. The study group consisted of 110 patients with newly diagnosed acute DVT in the lower extremities. An age, gender, and body mass index-matched control group consisted of 98 patients with normal duplex ultrasound findings. We compared the mean platelet volume in patients with acute DVT and control participants. ResultsThere was no significant difference between the study and control groups in mean platelet volume (8.8±1.6 vs 8.7±1.3 fl, respectively; p>0.05). Age (p=0.899), body mass index (p=0.43), gender (p=0.466), and platelet count (p=0.886) were statistically similar in both groups. ConclusionsThere was no significant difference in mean platelet volume between patients with acute DVT and the control group. According to our result, we propose that mean platelet volume should not be considered as an index of acute DVT.

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The mean platelet volume in patients with essential and white coat hypertension

Cited by 69 publications

References 25 publications

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

Increased platelet volume in a general population with prehypertension: a cross-sectional study of 80 545 participants from China

Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome and ST-elevation myocardial infarction

Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

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