Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

Kalkan, Ahmet; Memetoğlu, Mehmet Erdem; Bilir, Özlem; Ersunan, Gökhan; Kutlu, Rasim; Tutar, Nuri

doi:10.5505/1304.7361.2012.79037

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…Big platelets contain granules with higher densities compared to small platelets and they contain higher thrombotic potentials because they are more active enzymatically and metabolically. Prothrombotic components like thromboxane A2 are denser in large platelets (15,16). The platelet counts tend to decrease when MPV increases (17).…”

Section: Discussionmentioning

confidence: 99%

Migrenli Hastaların Kanında Ortalama Trombosit Hacmi ve Trombosit Sayısının Araştırılması

Varol¹,

Akıl²,

Çevik³

et al. 2013

Tnd

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Sum maryObjective: Mean platelet volume (MPV) is an indicator for platelet function and activation. Studies researching MPV and platelet level on the patients with migraine are insufficient. In this study, we aimed to find a difference in MPV and platelet count in individuals with migraine compared to healthy controls, which are indicators for platelet activation. We compared MPV and platelet counts between the patients with migraine and healthy controls. Both groups were similar in terms of age and gender. Re sults: A statistically insignificant increase was found in MPV in patients with migraine (7.98±1.34 fL) when compared to the control group (7.85±0.96 fL) (p=0.34). Platelet levels were significantly lower in patients with migraine (367.6±74.2) than the platelet levels of the control group (286.9±68.3) (p=0.02). Dis cus si on: We found lower platelet levels in the patients with migraine compared to the control group. There was also statistically insignificant increase in MPV in patients with migraine, suggesting that these findings may indicate an insignificant platelet activation in patients with migraine. New prospective studies are needed on this subject. Benzer yaş ve cinsiyette migren tanısı konmuş hastalar ile sağlıklı olan kontrol grubu arasında OTH ve trombosit sayıları karşılaştırıldı. Bulgular: Migren hastalarında OTH (7,98±1,34 fL) kontrol grubuna göre (7,85±0,96 fL) istatistiksel olarak anlamlı olmayan artış bulundu (p=0,34). Trombosit düzeyi migrenli hastalarda (267,6±74,2) kontrollere (286,9±68,3) göre anlamlı düzeyde düşüktü (p=0,02). Sonuç: Çalışmamızda trombosit sayısını migrenli hastalarda sağlıklı kontrol grubuna göre düşük bulurken OTH ise migrenli hastalarda kontrol grubuna göre istatistiksel olarak anlamlı olmayan artış bulduk. Bu bulgular migren hastalarında istatistiksel olarak belirgin olmayan trombosit aktivasyonunu gösterebilir. Bu konuda prospektif yeni çalışmalara ihtiyaç vardır. (

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Section: Discussionmentioning

confidence: 99%

Migrenli Hastaların Kanında Ortalama Trombosit Hacmi ve Trombosit Sayısının Araştırılması

Varol¹,

Akıl²,

Çevik³

et al. 2013

Tnd

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“…It is assumed that serotonin content and vesicle storage capacity are different for different-sized platelets [Geller et al, 1988]. Larger platelets contain more dense granules than small platelets and have more thrombotic potential, because they are enzymatically and metabolically more active [Giles, Smith, & Martin, 1994;Kalkan et al, 2012]. In addition, despite some controversy, larger and more granular platelets are thought to be younger than smaller ones, so processes that affect platelet halflife are thought to be reflected in platelet volume and thus platelet serotonin content [Amorosi, Garg, & Karpatkin, 1971;Freedman & Karpatkin, 1975;Paulus, 1975].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

et al. 2019

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Changes related to the serotonin system play a key role in the etiology of autism spectrum disorder (ASD). Although we know that platelets are associated with the serotonin system, their relation to ASD has not yet been elucidated. In this study, we aim to investigate platelet parameters in children with ASD. Forty patients with ASD according to Diagnostic and Statistical Manual of Mental Disorders 5 (DSM‐5) and 30 healthy controls were included in the study. A complete blood count was done to measure parameters relating to platelet morphology. Moreover, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were evaluated. Lastly, platelet functions were assessed with a platelet functions analyzer 100 (PFA‐100) device by measuring collagen‐ADP and collagen‐epinephrine (EPI) closure times. There was not a significant difference between the groups in terms of platelet count, mean platelet volume (MPV), platelet distribution width, plateletcrit, PT, or aPTT parameters for ASD patients when compared to the control group (P > 0.05). However, MPV in severe ASD, as quantified by the Childhood Autism Rating Scale, was found to be significantly lower when compared to mild to moderate ASD (P = 0.047). Moreover, in terms of platelet functions, the elongation in collagen‐ADP and collagen‐EPI closure times were significantly higher for the ASD group (P = 0.044). These results may suggest an impairment in platelet functions rather than in platelet morphology for children with ASD. Considering these results, further investigation of thrombocyte functions in the ASD may lead to a better understanding of the pathogenesis of ASD and to the development of our limited knowledge of this disorder. Autism Res 2019, 12: 1069–1076. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Serotonin is a chemical that is found in brain as wells as in blood cells that function in blood clotting in the human body. There are problems related to serotonin in brains of people who have autism. Thus, blood clotting cells may also be affected in people who have autism. In this study, we compare blood clotting functions of children with autism with that of healthy controls.

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“…In large platelets, there are more prothrombotic components such as thromboxane A2. [ 18 19 ] In conditions where MPV is increased, there is a tendency for a decrease in the platelet count[ 20 ] Therefore, because of increased bone marrow aggregation, there could be increased platelet production or increased platelet consumption. [ 13 ] The low platelet count of lumbago/sciatica patients in the current study could show that large platelets were more evident in lumbago/sciatica patients with a nonsignificant MPV level.…”

Section: Discussionmentioning

confidence: 99%

Investigation of mean platelet volume and platelet count in the blood of patients with lumbago and sciatica

Gökçek

Kaydu

2018

Anesth Essays Res

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Is Increased Mean Platelet Volume a Risk Factor in Patients with Acute Deep Vein Thrombosis?

Cited by 9 publications

References 22 publications

Migrenli Hastaların Kanında Ortalama Trombosit Hacmi ve Trombosit Sayısının Araştırılması

Migrenli Hastaların Kanında Ortalama Trombosit Hacmi ve Trombosit Sayısının Araştırılması

Evaluation of Platelet Parameters in Children with Autism Spectrum Disorder: Elongated Collagen‐Adenosine Diphosphate and Collagen‐Epinephrine Closure Times

Investigation of mean platelet volume and platelet count in the blood of patients with lumbago and sciatica

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