The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome

Yılmaz, Mücahid; Duran, Cevdet; Başaran, Mustafa

doi:10.1007/s40618-015-0335-2

Cited by 41 publications

(48 citation statements)

References 36 publications

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“…Ten of the eleven studies stratifying PCOS group according to BMI, revealed significantly higher circulating CRP in obese/overweight versus non-obese PCOS women, while one study showed no difference [96]. On the other hand, eight studies comparing between BMI strata in the control group reported higher CRP levels in the higher BMI group [51,59,78,87,98,100,115,122], while two studies revealed no difference [55,96]. Comparison between different BMI strata between PCOS women and controls is provided in the meta-analysis section below.…”

Section: Systematic Review 221 Crp Resultsmentioning

confidence: 98%

“…To further investigate the effect of obesity as a main confounder on inflammatory status, we separately looked at eleven studies that stratified their participants according to BMI [51,55,59,66,78,87,96,98,100,115,122] and two studies that included only obese participants only [45,110] (Table 1). Ten of the eleven studies stratifying PCOS group according to BMI, revealed significantly higher circulating CRP in obese/overweight versus non-obese PCOS women, while one study showed no difference [96].…”

Section: Systematic Review 221 Crp Resultsmentioning

confidence: 99%

“…Eight studies (n = 1026) assessed WCC in PCOS women (n = 610) versus healthy controls (n = 416) [46,47,70,77,85,87,98,101]. Of these, seven studies reported significantly higher WCC in PCOS versus control participants, while one study showed no difference between the two groups (Table 3)…”

Section: White Cell Count (Wcc)mentioning

confidence: 99%

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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

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Although the current literature associates polycystic ovarian syndrome (PCOS) with chronic inflammation, the evidence for this link remains inconclusive and its causal nature remains unclear. The purpose of this systematic review was to assess the inflammatory status in PCOS women and to determine whether it is related to PCOS or to its associated adiposity. We searched electronic databases including PUBMED, EMBASE and MEDLINE, SCOPUS, DynaMed plus, TRIP, ScienceDirect and Cochrane Library, for studies investigating C-reactive protein (CRP) and other inflammatory makers in PCOS women versus healthy controls. Quality and risk of bias for selected studies were assessed using the modified Newcastle–Ottawa scale. CRP data were extracted and pooled using RevMan for calculation of the standardized mean difference (SMD) and 95% confidence interval (CI). Eighty-five eligible studies were included in the systematic review, of which 63 were included in the meta-analysis. Pooled analysis of the 63 studies revealed significantly higher circulating CRP in PCOS women (n = 4086) versus controls (n = 3120) (SMD 1.26, 95%CI, 0.99, 1.53). Sensitivity meta-analysis of 35 high quality studies including non-obese women showed significantly higher circulating CRP in PCOS women versus controls (SMD 1.80, 95%CI, 1.36, 2.25). In conclusion, circulating CRP is moderately elevated in PCOS women independent of obesity, which is indicative of low-grade chronic inflammation.

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Section: Systematic Review 221 Crp Resultsmentioning

confidence: 98%

Section: Systematic Review 221 Crp Resultsmentioning

confidence: 99%

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The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Aboeldalyl

James

Seyam

et al. 2021

IJMS

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“…In a study conducted with patients who had PCOS, a negative correlation was detected between BMI, NLR and PLR 21 . In a study that was conducted by Yılmaz et al with obese patients who had PCOS, a positive correlation was detected between NLR and BMI 22 . In another study conducted by Aydın et al it was determined that NLR was higher and PLR was insignificant 23 .…”

Section: Discussionmentioning

confidence: 90%

Relationship between blood lipids, inflammation parameters and body composition

Mete

Değer

Zoroglu

2020

Cukurova Medical Journal

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The aim of this stuıdy was to determine the relation between inflammation markers, anthropometric measurements, and blood lipid values. Materials and Methods: The present study was conducted with 274 adult healthy subjects in 2019. The relationship between anthropometric measurements and blood lipid values of individuals, full blood count inflammation markers, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and lymphocyte monocyte ratio (LMR) were examined.. Results: The average age of the 274 subjects, who participated in the study, was 34 years. No significant differences were detected between the NLR, PLR and LMR ratios according to the BMI scores. A very weak and negative correlation was detected between PLR and skeletal muscle, basal metabolic rate, body fluid amount and lean mass; and a weak and negative correlation was detected between HDL and BMI, body fat amount, and internal fat amount. A weak and positive correlation was detected between NLR and LDL. Conclusion:There was a very weak correlation between anthropometric values and inflammation markers, a weakmoderate correlation between blood lipid levels, and a weak correlation between inflammation markers and cholesterol levels. Amaç: Bu çalışma ile inflamasyon belirteçleri ile antropometrik ölçüm değerleri ve kan lipit değerleri arasındaki ilişkinin tespit edilmesi amaçlanmıştır. Gereç ve Yöntem: Bu çalışma 2019 yılında 274 yetişkin sağlıklı kişi üstünde yapılmış bir çalışmadır. Kişilerin kan lipit değerleri, tam kan sayımı inflamasyon belirteçleri nötrofil lenfosit oranı (NLO), platelet lenfosit oranı (PLO) ve lenfosit monosit oranı (LMO) ile antropometrik ölçümleri arasındaki ilişki incelenmiştir. Bulgular: Çalışmaya katılan 274 kişinin yaş ortalaması 34'dür. BKİ'ne göre NLO, PLO ve LMO oranları arasında anlamlı fark bulunamamıştır. PLO ile iskelet kası, bazal metabolik hız, vücut sıvı miktarı ve yağsız kütle arasında anlamlı çok zayıf negatif korelasyon, HDL ile BMİ, vücut yağ miktarı, iç yağlanma miktarı arasında zayıf negatif yönde korelasyon bulunmuştur. İskelet kası ve vücut yağ miktarındaki artış total kolesterol seviyesinde azalışa neden olurken, iç yağlanma miktarındaki artış total kolesterol seviyesinde artışa neden olmaktadır. NLO ile LDL arasında pozitif yönde zayıf, NLO ile total kolesterol arasında pozitif yönde çok zayıf, LMO ile LDL arasında pozitif yönde çok zayıf korelasyon bulunmuştur. Sonuç: Antropometrik değerler ile inflamasyon belirteçleri arasında çok zayıf, kan lipit ile zayıf-orta düzey, inflamasyon belirteçleri ile kolesterol düzeyi arasında zayıf ilişki olduğu görülmüştür.

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“…In a previous study, women with PCOS had a higher MPV, neutrophil to lymphocyte ratio, neutrophil count, neutrophil to total leucocyte ratio, and basophil count compared with controls. 11 Yilmaz et al 11 showed that MPV and the neutrophil to lymphocyte ratio were significantly higher in women with PCOS, despite similar high-sensitivity C-reactive protein levels, compared with patients without PCOS. A positive correlation of high-sensitivity C-reactive protein levels and the WBC count and a negative correlation of MPV with BMI were also reported.…”

Section: Discussionmentioning

confidence: 99%

Peripheral hematological parameters in women with polycystic ovary syndrome

ALhabardi

Al‐Wutayd

Eltayieb³

et al. 2020

J Int Med Res

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Objective There have been few studies on hematological parameters (e.g., hemoglobin, red cell distribution width, white blood cells, and mean platelet volume), and polycystic ovary syndrome (PCOS). This study aimed to compare hematological parameters between women with PCOS and controls. Methods We performed an age-matched case–control study in Faisal bin Mishal Center for Infertility, Buraidah (Kingdom of Saudi Arabia). The cases were women with PCOS and an equal number of healthy women were enrolled as controls. The basic gynecological history was recorded and blood samples were analyzed for blood parameters using an automated hematology analyzer. Results The two groups (60 women in each arm of the study) were similar in age. However, body mass index was significantly higher in women with PCOs compared with controls. There were no significant differences in any of the hematological parameters (hemoglobin, red blood cells, red cell distribution width, white blood cells, platelets, and mean platelet volume) between the two groups. Conclusion There does not appear to be a significant difference in hematological parameters in Saudi women with PCOS and healthy controls. A larger study on this issue is required in the future.

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The mean platelet volume and neutrophil to lymphocyte ratio in obese and lean patients with polycystic ovary syndrome

Cited by 41 publications

References 36 publications

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

The Role of Chronic Inflammation in Polycystic Ovarian Syndrome—A Systematic Review and Meta-Analysis

Relationship between blood lipids, inflammation parameters and body composition

Peripheral hematological parameters in women with polycystic ovary syndrome

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