The ‘mauve factor’ of schizophrenia and porphyria, 5-hydroxyhaemopyrrole lactam, has low pharmacological potency on guinea-pig ileum

Gorchein, A.; At, Rogers

doi:10.1007/bf01949952

Cited by 4 publications

(2 citation statements)

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“…In mice, the highest dose of HPL raised plasma concentrations to 0.3 mmol/l, many fold above the human plasma concentrations of HPL (estimated maximum of 0.04 mmol/l) dur-ing acute porphyric attacks (Graham 1978b). Gorchein & Rogers (1979) likewise found a low pharmacological activity from 5-hydroxyhaemopyrrole lactam in guinea pig ileum. Additionally, the observation by Graham (1978b) of poor correlation between clinical severity of acute porphyria, schizophrenia or endogenous depression with the urinary concentrations of HPL supports the proposal that HPL is unlikely to play an aetiological role in any of these conditions.…”

Section: Discussionmentioning

confidence: 88%

“…Since the origin of the psychiatric syndrome of the acute porphyric attack remains unknown, an assessment of the effects of HPL upon behaviour has been undertaken. This compound, HPL, has been shown to inhibit contractile activity in guinea pig ileum (Gorchein & Rogers 1979), albeit a t high concentrations, but its behavioural activities have not previously been assessed.…”

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confidence: 99%

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The Mauve Factor of Porphyria, 3‐Ethyl‐5‐hydroxy‐4,5‐dimethyl‐delta‐3‐pyrroline‐2‐one: Effects on Behaviour of Rats and Mice

Cutler

Graham²

1990

Pharmacology & Toxicology

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The monopyrrole, 3-ethyl-5-hydroxy-4,5-dimethyl-delta 3-pyrroline-2-one (HPL), was given by intraperitoneal injection to rats (0.65 mmol/kg) and to mice (0.98 and 1.95 mmol/kg). Behaviour of the rats was assessed for 1.5 hr after injection by monitoring their spontaneous activity, while behaviour of the mice was examined by ethological procedures during dyadic encounters over a 5 min. period at 50-60 min. following injection. Activity of the rats, once habituated to the cage, was reduced by HPL. No other abnormalities were discernible. In mice, HPL at 1.95 mmol/kg increased the frequency of "head twitch" and evoked a smaller increase of "backward locomotion". There were no changes in overall agonistic, social or non-social behaviour in the HPL treated mice. Plasma concentrations of HPL in mice treated with the highest dose level amounted to 0.3 +/- 0.1 mmol/l, many-fold above its plasma concentrations during acute porphyric attacks in man. It thus appears that in rodents HPL has slight behavioural activity, but that it is unlikely to play any significant role in the psychiatric disturbances of acute porphyria.

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Section: Discussionmentioning

confidence: 88%

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confidence: 99%