Monopyrroles in porphyria, psychosis and lead exposure

Moore, M. R.; Graham, D.

doi:10.1016/0020-711x(80)90171-8

Cited by 12 publications

(2 citation statements)

References 23 publications

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“…Many useful and intriguing questions about lead remain to be studied. Lead produces changes in the heme pathway similar in some ways to those found in acute intermittent porphyria (Moore & Graham, 1980). Are the behavioural features of lead and porphyria related then to the same heme products?…”

mentioning

confidence: 84%

The neuropsychiatric implications of low level exposure to lead

Needleman¹

1982

Psychol. Med.

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mentioning

confidence: 84%

The neuropsychiatric implications of low level exposure to lead

Needleman¹

1982

Psychol. Med.

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“…Increases in pyrrole levels and excretion may occur as a result of stress-induced changes in intestinal permeability, which in turn leads to increased pyrrole absorption. To the extent that pyrrole excretion may be an indicator of heme breakdown due to emotional stress, oxidative stress, or nutrient deprivation, a study of the correlation between urinary pyrroles and nutrient levels should be of interest [18,[20][21][22].…”

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confidence: 99%

Clinical Test of Pyrroles: Usefulness and Association with Other Biochemical Markers

Mikirova¹

2015

Clin Med Rev Case Rep

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Background: Psychiatrists started using urine pyrroles (hydroxyhemopyrrolin-2-one, HPL) to diagnose mental disorders many years ago. The biological origins of HPL are not known, nor are the causes of elevated urinary pyrrole excretion well understood. Methods:In the present study we analyzed the level of pyrroles in 148 patients with schizophrenia, 135 patients with bipolar disorder, 97 patients with depression, and 119 patients with ADHD and compared these data with the results of pyrrole tests for patients with non-mental conditions and healthy volunteers.Results: According to our data, urinary pyrrole concentrations tended to be high in patients with mental illnesses, but elevated level of pyrroles was not specific for only these patients. We found evidence of an allergy related component in the fact that elevated pyrrole levels were significantly more prevalent in subjects with elevated histamine values. A role of intestinal bacteria, or imbalances in intestinal bacterial metabolism, was also suggested based on the found relationship between elevated pyrrole levels and elevations in indicans and urobilinogens. In addition, our data demonstrated that subjects with severely elevated pyrrole levels were deficient in nutrients such as zinc, vitamin B3, and vitamin C. Conclusion:Thus, pyrrole excretion seems to be a component of illness in general and not strictly mental illness.

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An Historical Introduction to Porphyrin and Chlorophyll Synthesis

Moore

2009

Tetrapyrroles

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Monopyrroles in porphyria, psychosis and lead exposure

Cited by 12 publications

References 23 publications

The neuropsychiatric implications of low level exposure to lead

The neuropsychiatric implications of low level exposure to lead

Clinical Test of Pyrroles: Usefulness and Association with Other Biochemical Markers

An Historical Introduction to Porphyrin and Chlorophyll Synthesis

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