The maternal gut microbiome during pregnancy and offspring allergy and asthma

Yuan, Gao; Nanan, Ralph; Macia, Laurence; Tan, Jian; Sominsky, Luba; Quinn, Thomas P.; O’Hely, Martin; Ponsonby, Anne–Louise; Tang, Mimi L.K.; Collier, Fiona; Strickland, Deborah H.; Dhar, Poshmaal; Brix, Susanne; Phipps, Simon; Sly, Peter D.; Ranganathan, Sarath; Stokholm, Jakob; Kristiansen, Karsten; Gray, Lawrence; Vuillermin, Peter

doi:10.1016/j.jaci.2021.07.011

Cited by 58 publications

(34 citation statements)

References 158 publications

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“…For example, Acinetobacter species, both on human skin and on mice, are effective immunoregulators and associated with allergy and asthma risk 10‐12 . Maternal carriage of Prevotella copri during pregnancy decreases the offspring's risk of allergic disease and asthma 13 . In the gut, Morganella species has a potential causal effect on major depressive disorder 14 .…”

Section: Biodiversity Fundamental For Human Lifementioning

confidence: 99%

“…[10][11][12] Maternal carriage of Prevotella copri during pregnancy decreases the offspring's risk of allergic disease and asthma. 13 In the gut, Morganella species has a potential causal effect on major depressive disorder. 14 Overall, the interaction of human microbiome with epigenetic modulation of genetic expression regulates disease risk but is still poorly understood.…”

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confidence: 99%

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Biodiversity for resilience—What is needed for allergic children

Haahtela

2022

Pediatric Allergy Immunology

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What is needed for our children facing unprecedented challenges of modern time? Biodiversity, both for immunological and psychological well‐being and resilience. That is also the keyword for the children with allergies and asthma. The cultural evolution with advanced technology and medicine along with major move to urban environment has profoundly changed our lifestyle and surroundings. We are increasingly disconnected from our evolutionary home, soil, natural waters, and air we used to breathe. The ecosystem of human body and mind has been tested, survived, and evolved closely in relation with other ecosystems. For balance and tolerance, immune regulatory circuits need training by microbes, biogenic chemicals, and close relation to natural environment throughout life. This is addressed by the biodiversity hypothesis of tolerance/resilience for health, supported by the pioneering real‐world interventions and a few controlled studies. No need to go “back to nature,” but we must take natural elements back to our everyday life to breathe, eat, drink, and touch. The change for better is plausible and cost‐effective, as shown by the Finnish and other European initiatives, but needs contribution of the whole society.

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Section: Biodiversity Fundamental For Human Lifementioning

confidence: 99%

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confidence: 99%

Biodiversity for resilience—What is needed for allergic children

Haahtela

2022

Pediatric Allergy Immunology

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“…An abnormal microbiome can colonize an infant, impair immune system development after birth, and have long-term effects on health problems such as the development of allergies. Prenatal, inter-pregnant, or neonatal use of antibiotics can adversely affect the development of the neonatal gut microbiome and immune system, contributing to food allergies, asthma, necrotizing enterocolitis, obesity, and more in children ( Table 2 ) ( Milliken et al., 2019 ; Gao et al., 2021 ). All of these diseases have an overall delay in microbial maturation.…”

Section: Gut Microbiome and Immune System Diseases Of Infantsmentioning

confidence: 99%

The Complex Link and Disease Between the Gut Microbiome and the Immune System in Infants

Zhang

Liao

et al. 2022

Front. Cell. Infect. Microbiol.

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The human gut microbiome is important for human health. The development of stable microbial communities in the gastrointestinal tract is closely related to the early growth and development of host immunity. After the birth of a baby, immune cells and the gut microbiome mature in parallel to adapt to the complex gut environment. The gut microbiome is closely linked to the immune system and influences each other. This interaction is associated with various diseases in infants and young children, such as asthma, food allergies, necrotizing colitis, obesity, and inflammatory bowel disease. Thus, the composition of the infant gut microbiome can predict the risk of disease development and progression. At the same time, the composition of the infant gut microbiome can be regulated in many ways and can be used to prevent and treat disease in infants by modulating the composition of the infant gut microbiome. The most important impacts on infant gut microbiota are maternal, including food delivery and feeding. The differences in the gut microbiota of infants reflect the maternal gut microbiota, which in turn reflects the gut microbiota of a given population, which is clinically significant.

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“…The session on microbiome highlighted the role of skin microbiota, microbiome and innate immunity and microbiome in early life and its relation to allergic diseases [ 1 2 ].…”

Section: Microbiome and Immune System In Health And Disease And Epith...mentioning

confidence: 99%