The material and biological characteristics of osteoinductive calcium phosphate ceramics

Abstract

The discovery of osteoinductivity of calcium phosphate (Ca-P) ceramics has set an enduring paradigm of conferring biological regenerative activity to materials with carefully designed structural characteristics. The unique phase composition and porous structural features of osteoinductive Ca-P ceramics allow it to interact with signaling molecules and extracellular matrices in the host system, creating a local environment conducive to new bone formation. Mounting evidence now indicate that the osteoinductive activity of Ca-P ceramics is linked to their physicochemical and three-dimensional structural properties. Inspired by this conceptual breakthrough, many laboratories have shown that other materials can be also enticed to join the rank of tissue-inducing biomaterials, and besides the bones, other tissues such as cartilage, nerves and blood vessels were also regenerated with the assistance of biomaterials. Here, we give a brief historical recount about the discovery of the osteoinductivity of Ca-P ceramics, summarize the underlying material factors and biological characteristics, and discuss the mechanism of osteoinduction concerning protein adsorption, and the interaction with different types of cells, and the involvement of the vascular and immune systems.

Positive role of calcium phosphate ceramics regulated inflammation in the osteogenic differentiation of mesenchymal stem cells

“…At day 7, all the aforementioned growth factors in bioceramic groups reduced in comparison to the control. It is worth noting that protein secretion profiles of growth factors were not in accordance with the gene expression results, this may be ascribed to the strong adsorption of Ca‐P ceramics for growth factors as previously reported (Chen, Wang, et al, ; Tang, Li, Tan, Fan, & Zhang, ; Zhu et al, ).…”

Surface modification of chitosan films with a fibronectin fragment–DNA aptamer complex to enhance osteoblastic cell activity: A mass spectrometry approach probing evidence on protein behavior

“…Biomaterials are widely used to develop active medical devices capable of promoting tissue regeneration and functional restoration . During these processes, the extracellular matrix (ECM) with its complex and dynamic microenvironment plays a pivotal role in regulating cell adhesion, growth and proliferation .…”

“…Biomaterials are widely used to develop active medical devices capable of promoting tissue regeneration and functional restoration. 1,2 During these processes, the extracellular matrix (ECM) with its complex and dynamic microenvironment plays a pivotal role in regulating cell adhesion, growth and proliferation. 3,4 Thus, the direct combination of scaffolds functionalized with simplified ECM proteins is widely studied as a promising approach for a broad range of biomedical applications.…”

Strontium‐substituted biphasic calcium phosphate microspheres promoted degradation performance and enhanced bone regeneration

“…β-TCP with a lower Ca/P ratio of 1.5 possesses better degradability than HA and has been extensively studied for bone regeneration. Moreover, it has been proven that the potential of osteoinductivity is BCP > β-TCP > HA (Samavedi, Whittington, & Goldstein, 2013), which is affected by material characteristics including ionic environment, phase composition, degradation, and structure (Tang, Li, Tan, Fan, & Zhang, 2018). In addition, improvement in maturity of new bone formed by β-TCP is needed as our previous study demonstrated (Li, Liu, et al, 2017).…”