The Management of Recurrent Gliomas

Jl, Pool

doi:10.1093/neurosurgery/15.cn_suppl_1.265

Cited by 31 publications

(8 citation statements)

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“…Glioblastoma possesses two variants, the giant cell glioblastoma and gliosarcoma, and is the most common and aggressive form of brain tumor (11,12). Glioblastoma is associated with high mortality and can strongly invade adjacent normal tissues (13).…”

Section: Introductionmentioning

confidence: 99%

Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells

Shi

Chen

et al. 2015

Molecular Medicine Reports

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Spindle and kinetochore‑associated protein 1 (SKA1) is an important component of the human kinetochore, which plays a key role in mitosis. The resent study was designed to investigate the role of SKA1 in human glioblastoma. The results of the present study demonstrated that SKA1 was expressed in human glioblastoma cells. In addition, the knockdown of SKA1 expression in the A172 and U251 human glioblastoma cell lines was accomplished using a lentivirus infection method. An MTT assay demonstrated that downregulation of SKA1 may inhibit cell proliferation, without affecting the cell cycle. Furthermore, knockdown of SKA1 expression resulted in reduced cell invasion. The results of the present study indicated that SKA1 may be a potential target protein for antiproliferative and anti‑invasive therapeutic strategies of human glioblastoma.

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Section: Introductionmentioning

confidence: 99%

Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells

Shi

Chen

et al. 2015

Molecular Medicine Reports

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“…In these cases, re-operation seems to be the last therapeutic option. Nevertheless, the existing studies on the question, if re-operation is useful could not answer this question [1,2,3,5,9,14,18,20,21,23,24,25,26]. In addition there are only a few studies available considering re-operation on patients with recurrent glioblastoma multiforme alone [5,6,9,26].…”

Section: Discussionmentioning

confidence: 99%

Experiences with reoperation on recurrent glioblastoma multiforme

Pinsker¹,

Lumenta²

2002

Zentralbl Neurochir

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“…Many methods of treating gliomas have been tried, e.g. partial or complete removal by surgery [24][25][26][27][28][29][30][31][32][33][34], chemotherapy [35][36][37], surgery and irradiation, and a combination of all three [38][39][40][41]. In recent years the immuno-therapy [42] and the antibody guided irradiation of brain glioma have been reported [43].…”

Section: Discussionmentioning

confidence: 99%

Application of invasive microwave hyperthermia for the treatment of gliomas

et al. 1988

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Twenty five cases of gliomas of the brain were operated upon by debulking the tumour masses. Following this, microwave hyperthermia was given by heating a measured volume of Ringer's solution instilled into the tumour cavity. This was followed by a 'dry treatment' without Ringer's solution. The follow up of these cases revealed that 11 cases have died and 14 cases are alive post-operatively. For those that are alive, the follow up period ranges from 21 to 41 months with the mean survival period of 31.1 months; in this group, 12 cases have a Kanofsky scale of 80-100, i.e. they are fully independent. The other two cases have a score of 50 or under and they need institutional care. In this study, we believe that the first order effect of microwave hyperthermia is predominantly thermal and in the published literature, and in this investigation, there is no clear evidence that microwave radiation produces any other beneficial and quantifiable effect on the tissue.

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The Management of Recurrent Gliomas

Cited by 31 publications

References 0 publications

Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells

Lentivirus-mediated silencing of spindle and kinetochore-associated protein 1 inhibits the proliferation and invasion of neuronal glioblastoma cells

Experiences with reoperation on recurrent glioblastoma multiforme

Application of invasive microwave hyperthermia for the treatment of gliomas

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