The Management of Dysplasia, Carcinoma in Situ and Microcarcinoma of the Cervix

Brudenell, M; Cox, B. S.; Taylor, C. W.

doi:10.1111/j.1471-0528.1973.tb16048.x

Cited by 38 publications

(1 citation statement)

References 4 publications

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“…It is impossible to be certain that the original histology of CIN is comparable between studies. Some studies consider only women with carcinoma in situ (Boyes et al 1970; Brudenell et al 1973; Creasman & Rutledge 1972; Kolstad & Klem 1976); some consider those with carcinoma in situ and/or severe dysplasia (Gemmell et al 1990); carcinoma in situ and severe dysplasia (Kirkup et al 1979); some, like us, consider women with any grade of CIN (Fawdry 1984). In some studies, it is impossible to differentiate betweeen the new and the persistent disease (Brudenell et al 1973; Kolstad & Klem 1976; Gemmell et al 1990).…”

Section: Discussionmentioning

confidence: 99%

Long term follow up of women after hysterectomy with a history of pre‐invasive cancer of the cervix

Wiener

Sweetnam

Jones

1992

BJOG

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Objective A long term review of women after hysterectomy with a history of pre‐invasive carcinoma of the cervix. Design 193 women had cervical intra‐epithelial neoplasia and two had adenocarcinoma in situ either at hysterectomy or at previous cone biopsy. These were followed up by annual cytology. Setting South Glamorgan Health Authority. Subjects Of 195 women who had a hysterectomy, 143 have been followed up cytologically for more than 10 years and 43 for more than 20 years: a total of 2800 women years of experience. Main outcome measures Timing of abnormal smears. Results A detailed reviw of the five women with abnormal smears. The estimated percentage of women who remain negative is 98% at five years, 98.4%, at 10 years and 96.5 % at 20 years. Conclusion Cytological screening ofall women who had a hysterectomy with a history of CIN is indicated for the first two years after hysterectomy. Thereafter the estimated incidence of 0.7 per 1000 women years is higher than the general population but it is not a sufficient reason to screen more frequently. We recommend screening for the carcinoma of the vagina to be every three years which is the same screening frequency as for cervical carcinoma in the general population.

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Section: Discussionmentioning

confidence: 99%

Long term follow up of women after hysterectomy with a history of pre‐invasive cancer of the cervix

Wiener

Sweetnam

Jones

1992

BJOG

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Effectiveness of Vaginal Papanicolaou Smear Screening After Total Hysterectomy for Benign Disease

Fetters

Fischer

Reed

1996

JAMA

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Diagnosis and management of microinvasive (stage IA) carcinoma of the uterine cervix

Averette

Nelson

et al. 1976

Cancer

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One hundred and sixty-two cases of Stage IA microinvasive carcinoma of the cervix are presented. These patients represent the combined experience at the University of Miami School of Medicine, Miami, Florida, and Downstate Medical Center, Brooklyn, New York. The criteria used in both institutions are 1) penetration of invasive carcinoma beneath the basement membrane of less than 1 mm and 2) absence of invasion of blood vessel or lymphatic spaces. All tissue specimens have been measured accurately by use of calibrated optics. The literature has been reviewed for criteria of diagnosis of microinvasive cancer, as well as methods of management. Our method of accurately determining depth of penetration is described and the evolution of microinvasive cancer is presented in a series of photomicrographs in which measurements are accurate to 0.1 mm. In the literature, when depth of penetration of up to 5 mm is used as criterion for microinvasive carcinoma, the incidence of nodal metastasis may be as high as 3.5%. Since, in our combined institutions, the mortality rate with radical hysterectomy is less than 1% and the incidence of ureterovaginal fistulas is 1.2%, we conclude that simple hysterectomy is not adequate therapy for lesions with stromal invasion to a depth of 5 mm.

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The Management of Dysplasia, Carcinoma in Situ and Microcarcinoma of the Cervix

Cited by 38 publications

References 4 publications

Long term follow up of women after hysterectomy with a history of pre‐invasive cancer of the cervix

Long term follow up of women after hysterectomy with a history of pre‐invasive cancer of the cervix

Effectiveness of Vaginal Papanicolaou Smear Screening After Total Hysterectomy for Benign Disease

Diagnosis and management of microinvasive (stage IA) carcinoma of the uterine cervix

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