The management of asthmatic smokers

Chatkin, José Miguel; Dullius, Cynthia Rocha

doi:10.1186/s40733-016-0025-7

Cited by 38 publications

(34 citation statements)

References 66 publications

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“…The finding that current smoking is associated with worse asthma control has also been found by others [6,8] and may reflect the fact that cigarette smoke is known to reduce the response to ICS in asthmatic patients [15,16]. Furthermore, there is good evidence that asthma outcome improves in several ways after smoking cessation [3,5], which is also in line with our observation that ex-smokers had their asthma better controlled than current smokers.…”

Section: Discussionsupporting

confidence: 90%

“…Approximately 20% of asthmatics are smokers [1][2][3]. Among asthmatic patients, smoking is associated with increased morbidity and mortality, a higher frequency of asthma exacerbations, accelerated decline of lung function, reduced response to inhaled corticosteroids, and increased asthma severity, when compared to non-smoking asthmatics [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland

et al. 2020

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Background: Surprisingly little is known about asthma control among asthmatics who smoke. The aim of this cross-sectional study was to investigate asthma symptom control according to the GINA guidelines among asthmatics with a clinically significant smoking history. Methods: One hundred ninety asthmatics from primary care in Finland were investigated. The patients were current or previous cigarette smokers with a history of 10 or more pack-years. They completed a questionnaire including questions on asthma symptoms and reliever use so that their level of asthma symptom control (well controlled, partly controlled, or uncontrolled) according to GINA could be determined. Results: Sixty-six (34.7%) patients had their asthma well controlled, 81 (42.6%) had their asthma partly controlled, and 43 (22.6%) had uncontrolled asthma. Current smokers had uncontrolled asthma more often than ex-smokers, OR 2.54 (95% CI 1.25-5.14, p = 0.01). Patients with moderate to severe asthma exacerbation during the previous year had uncontrolled asthma more often than patients without an exacerbation, OR 2.17 (95% CI 1.06-4.47, p = 0.04), and patients with FEV 1 < 80% of predicted had uncontrolled asthma more often than patients with FEV 1 > 80% of predicted, OR 2.04 (95% CI 1.02-4.08, p = 0.04). Conclusions: Asthmatic patients with a clinically significant smoking history often do not have well controlled asthma. Poor asthma symptom control was associated with current smoking status, history of exacerbations and impaired lung function. Therefore, every attempt should be made to help asthmatics who smoke to quit smoking.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland

et al. 2020

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“…The finding that current smoking is associated with worse asthma control has also been found by others (6,8) and may reflect the fact that cigarette smoke is known to reduce the response to ICS in asthmatic patients (15,16). Furthermore, there is good evidence that asthma outcome improves in several ways after smoking cessation (3,5), which is also in line with our observation that ex-smokers had their asthma better controlled than current smokers. Funding: The study was funded by Boehringer Ingelheim Finland, but the authors designed the study, recruited the study sites to collect the data, analysed and interpreted the data and wrote the manuscript.…”

Section: Discussionsupporting

confidence: 89%

Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland

Lehtimäki¹,

Kiljander²,

Poussa³

et al. 2020

Preprint

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Background Surprisingly little is known about asthma control among asthmatics who smoke. The aim of this cross-sectional study was to investigate asthma symptom control according to the GINA guidelines among asthmatics with a clinically significant smoking history. Methods One hundred ninety asthmatics from primary care in Finland were investigated. The patients were current or previous cigarette smokers with a history of 10 or more pack-years. They completed a questionnaire including questions on asthma symptoms and reliever use so that their level of asthma symptom control (well controlled, partly controlled, or uncontrolled) according to GINA could be determined. Results Sixty-six (34.7%) patients had their asthma well controlled, 81 (42.6%) had their asthma partly controlled, and 43 (22.6%) had uncontrolled asthma. Current smokers had uncontrolled asthma more often than ex-smokers, OR 2.54 (95% CI 1.25-5.14, p=0.01). Patients with moderate to severe asthma exacerbation during the previous year had uncontrolled asthma more often than patients without an exacerbation, OR 2.17 (95% CI 1.06-4.47, p=0.04), and patients with FEV1 < 80% of predicted had uncontrolled asthma more often than patients with FEV1 > 80% of predicted, OR 2.04 (95% CI 1.02-4.08, p=0.04). Conclusions Asthmatic patients with a clinically significant smoking history often do not have well controlled asthma. Poor asthma symptom control was associated with current smoking status, history of exacerbations and impaired lung function. Therefore, every attempt should be made to help asthmatics who smoke to quit smoking.

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“…In the respiratory tract, smoking is related to upper respiratory tract infection, asthma, chronic obstructive pulmonary disease, nasopharyngeal cancer, and lung cancer. 2,[8][9][10] Smoking is a significant risk factor for respiratory diseases, considering its ability to lead to an alteration of nasal mucociliary clearance (NMC). 2,11,12 Nasal mucociliary clearance is the primary innate defense mechanism of the nose and paranasal sinuses, and it consists of mucous layer, airway surface liquid layer, and ciliary epithelia.…”

Section: Introductionmentioning

confidence: 99%

Nasal Mucociliary Clearance in Smokers: A Systematic Review

Prasetyo

Sadhana

Budiman

2020

Int Arch Otorhinolaryngol

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Introduction Smoking is one of the most important causes of mortality and morbidity in the world, as it is related to the risk factor and etiology of respiratory-tract diseases. Long-term smoking causes both structural and functional damage in the respiratory airways, leading to changes in nasal mucociliary clearance (NMC). Objectives The aim of the present study was to look systematically into the current literature and carefully collect and analyze results to explore NMC in smokers. Data Synthesis Two independent reviewers conducted a literature search on some Electronic database: Pubmed, Medline, Ebsco, Springer Link, Science Direct, Scopus, and Proquest searching for articles fulfilling the inclusion and exclusion criteria. The lead author independently assessed the risk of bias of each of the included studies and discussed their assessments with the other two authors to achieve consensus. Of the 1,654 articles identified in the database search, 16 met the criteria for this review. Most of the articles (15 out of 16) showed the impairment of NMC in smokers. Conclusion The present systematic review suggests that there is an impairment of NMC in smokers. The impairment is not only observed in cigarette smoking, but also in passive smoking, bidi smoking, electronic smoking, and hookah smoking. The impairment of NMC in chronic exposure to smoking is caused by the ciliotoxic effect, hypersecretion and viscoelastic change of mucous, airway surface liquid depletion, increased oxidative stress, and deteriorations in the inflammatory and immune systems.

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The management of asthmatic smokers

Cited by 38 publications

References 66 publications

Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland

Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland

Symptom control among asthmatics with a clinically significant smoking history: a cross-sectional study in Finland

Nasal Mucociliary Clearance in Smokers: A Systematic Review

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