The Management of Acute Leukaemia in Adults

Aleukaemic Myeloblastic Leukaemia

“…One of us (R. B. T.) has further unpublished evidence pointing to the same conclusion. On the other hand, steroid therapy is recommended for both lymphoblastic and myeloblastic leukaemias by Scott (1955), and by Hayhoe and Whitby (1955), although it is clear that the responses in myeloblastic leukaemia are poorer. It seems likely, therefore, that not all myeloblastic cases show acceleration of the leukaemic process under the influence of steroids.…”

Joe Burchenal and the birth of combination chemotherapy

“…Hayhoe reported, in the first paper of the first volume of the British Journal of Haematology , his experience of giving fresh blood transfusions to patients. A number of their patients achieved a complete, but short‐lived, remission (Hayhoe & Whitby, 1955).…”

The Complete Spleen

“…Primary Hypersplenism Syndromatic hypersplenism may occur with moderate-to-gross enlargement of the spleen without evidence of underlying disease: Although uncommon, it is not excessively rare. This condition has been described as nontropical idiopathic splenomegaly (Dacie et aI., 1969;Manoharan et aI., 1982), but it is probable that conditions variously described as primary splenic neutropenia (Wiseman and Doan, 1942), primary hypersplenic pancytopenia (Hayhoe and Whitby, 1955), and simple splenic hyperplasia are variants of the same syndrome (see also Table 4). …”