The management correlation between metabolic index, cardiovascular health, and diabetes combined with cardiovascular disease

Abstract

BackgroundCardiovascular disease (CVD) has become a major cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Although there is also evidence that multifactorial interventions to control blood glucose, blood pressure, and lipid profiles can reduce macrovascular complications and mortality in patients with T2DM, the link between these risk factors has not been established.MethodsOn 10 December 2018, 1,920 people in four cities in Anhui Province were included. Latent category analysis (LCA) was used to explore the clustering mode of HRBs (health risk behaviors). The primary exposure was HRBs and exercise and diet interventions, and the primary outcome was CVD and other variables, including zMS, triglyceride-glucose index (TyG), TyG-WC (waist circumference), TyG-BMI, TG/HDL, and cardiovascular health (CVH). A multivariable logistic regression model was used to establish the relationship between HRBs, exercise, diet interventions, and CVD. Moderate analysis and mediation moderation analysis were employed by the PROCESS method to explore the relationship between these variables. Sensitivity analysis explored the robustness of the model.ResultsThe mean age was 57.10 ± 10.0 years old. Overall, CVD affects approximately 19.9% of all persons with T2DM. Macrovascular complications of T2DM include coronary heart disease, myocardial infarction (MI), cardiac insufficiency, and cerebrovascular disease. Elderly age (χ2 = 22.70), no occupation (χ2 = 20.97), medium and high socioeconomic status (SES) (χ2 = 19.92), higher level of TyG-WC (χ2 = 6.60), and higher zMS (χ2 = 7.59) were correlated with high CVD. Many metabolic indices have shown a connection with T2DM combined with CVD, and there was a dose−response relationship between HRB co-occurrence and clustering of HRBs and zMS; there was a dose−response relationship between multifactorial intervention and CVH. In the mediation moderation analysis, there was an association between HRB, gender, TyG, TyG-BMI, and CVD. From an intervention management perspective, exercise and no diet intervention were more significant with CVD; moreover, there was an association between intervention management, gender, zMS, TyG-WC, TyG-BMI, TG/HDL, and CVD. Finally, there was an association between sex, CVH, and CVD. Sensitivity analysis demonstrated that our results were robust.ConclusionsCVD is one of the common complications in patients with type 2 diabetes, and its long-term outcome will have more or less impact on patients. Our findings suggest the potential benefits of scaling up multifactorial and multifaceted interventions to prevent CVD in patients with T2DM.

Triglyceride glucose index and renal function decline in Han Chinese hypertensive patients

“… 6 As an alternative to the conventional gold standard hyperinsulinemic‐euglycemic clamp method, the TyG index was introduced as a more simple and cost‐effective means of IR with high sensitivity (96.5%) and specificity (85%). 14 Currently, the TyG index has been extensively explored in diverse medical issues, such as cardiovascular disease, 6 , 7 , 8 , 9 arterial stiffness progression, 10 diabetic nephropathy, 11 new‐onset hypertension, 15 cardiometabolic diseases, 16 DM, 17 , 18 , 19 intensity care unit mortality, 20 obesity, 21 and hearing impairment. 22 However, there are relative few reports about TyG index and hypertensive nephropathy.…”

“…In this context, the triglyceride glucose (TyG) index has emerged as a non‐invasive and cost‐effective alternative indicator to assess IR. 5 Recent studies have shown that an elevated TyG index is associated with an increased risk of cardiovascular disease, 6 , 7 , 8 , 9 arterial stiffness progression, 10 and diabetic nephropathy. 11 However, evidence supporting the association between the TyG index and hypertension‐induced renal injury remains limited.…”

Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction

“…Recent research has also revealed that the TyG-BMI index is an independent risk factor for multivessel coronary atherosclerotic heart disease (CAD) in addition to being highly linked with CAD severity 20 . In individuals with coronary heart disease, The TyG-BMI index could be linked to cardiovascular incidents 21 . The effect of the TyG-BMI index on the prognosis of patients with STEMI has, however, received less attention in research.…”

miR-449a disturbs atherosclerotic plaque stability in streptozotocin and high-fat diet-induced diabetic mice by targeting CEACAM1

“…Known from the early events of inflammation and inflammatory core formation, VSMCs respond to inflammation by producing collagen and then forming a fibrous cap against plaque rupture and thrombosis [ 8 , 9 ]. Macrovascular complications, including AS, are major causes of morbidity and mortality in T2DM patients [ 10 ]. Although knowledge of the pathology of AS and exploration of abundantly regulatory genes over the past decades, the outcome of DM-associated AS remains unsatisfactory.…”