Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction

Abstract

Triglyceride glycemic-body mass index (TyG-BMI) is a simple and reliable surrogate for insulin resistance (IR). However, it is still unclear if TyG-BMI has any predictive value in patients having percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). The purpose of this study was to examine the TyG-BMI index's prognostic significance and predictive power in patients with STEMI. The study comprised a total of 2648 consecutive STEMI patients who underwent PCI. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE), defined as the combination of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and coronary revascularization. The TyG-BMI index was formulated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2] × BMI. 193 patients in all experienced MACE over a median follow-up of 14.7 months. There was a statistically significant difference between the Kaplan–Meier survival curves for the TyG-BMI index tertiles (log-rank test, p = 0.019) for the cumulative incidence of MACE. The adjusted HRs for the incidence of MACE in the middle and highest quartiles of the TyG-BMI index compared with the lowest quartile were 1.37 (95% CI 0.92, 2.03) and 1.53 (95% CI 1.02, 2.29), respectively, in the fully adjusted Cox regression model. At six months, one year, and three years, the TyG-BMI area under the curve (AUC) for predicting MACE was 0.691, 0.666, and 0.637, respectively. Additionally, adding the TyG-BMI index to the risk prediction model enhanced outcome prediction. In STEMI patients undergoing PCI, TyG-BMI was independently linked to MACE. TyG-BMI could be a simple and solid way to assess MACE risk and prognosis.

The association between triglyceride glucose-body mass index and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective study from MIMIC-IV database

“…Numerous studies have demonstrated the usefulness and effectiveness of the TyG-BMI index for assessing IR [ 26 , 27 ]. Recently, studies found that TyG-BMI could be a simple and solid index to assess the risk of major adverse cardiovascular events (MACEs), and higher TyG-BMI index was related to an increased incidence of MACEs [ 15 , 28 ]. In addition, Chen L et al also found that TyG-BMI index was independently correlated with both prehypertension and hypertension [ 29 ].…”

Long-term survival in stroke patients: insights into triglyceride-glucose body mass index from ICU data

“…The BMI, commonly used to gauge obesity, shows a significant positive correlation with stroke incidence, as evidenced by multiple studies [28][29][30]. The combined TyG-BMI metric is a valuable tool for assessing IR [18,[21][22][23][24]31], demonstrating its utility in evaluating major adverse cardiovascular event risk, particularly in patients having ST-elevation myocardial infarction (STEMI) and those with pre-HTN or HTN [32,33]. Moreover, elevated TyG-BMI levels have been found to be related to an increased stroke incidence, though this relationship has primarily been documented within the Chinese population, highlighting the need for further research across different ethnicities to corroborate these findings [21][22][23][24].…”

Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease

“…The prognostic value of the TyG-BMI index in relation to adverse cardiovascular (CV) outcomes, especially all-cause mortality [ 16 , 17 ],has been corroborated by several studies [ 16 – 19 ]. One cross-sectional study found that TyG-BMI index was negatively correlated with early-onset HF in patients with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention (PCI) [ 20 ].…”