The Male Role in Pregnancy Loss and Embryo Implantation Failure

Bronson, Richard

doi:10.1007/978-3-319-18881-2

Cited by 6 publications

(2 citation statements)

References 512 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the impact of seminal plasma on embryo development has been addressed in several experiments. Studies in mice show that at conception, seminal fluid elicits molecular and cellular changes in the oviduct and endometrium that directly promote embryo development and implantation competence (Schjenken & Robertson 2015). In particular, seminal fluid initiates female immune adaptation processes required to tolerate male antigens present in seminal fluid (Robertson et al 2009).…”

Section: Oviductal Response To Spermmentioning

confidence: 99%

Oviductal response to gametes and early embryos in mammals

Maillo¹,

Sánchez‐Calabuig²,

Lopera-Vásquez³

et al. 2016

Reproduction

View full text Add to dashboard Cite

The oviduct is a complex and organized thin tubular structure connecting the ovary with the uterus. It is the site of final sperm capacitation, oocyte fertilization and, in most species, the first 3-4 days of early embryo development. The oviductal epithelium is made up of ciliary and secretory cells responsible for the secretion of proteins and other factors which contribute to the formation of the oviductal fluid. Despite significant research, most of the pathways and oviductal factors implicated in the crosstalk between gametes/early embryo and the oviduct remain unknown. Therefore, studying the oviductal environment is crucial to improve our understanding of the regulatory mechanisms controlling fertilization and embryo development. In vitro systems are a valuable tool to study in vivo pathways and mechanisms, particularly those in the oviducts which in livestock species are challenging to access. In studies of gamete and embryo interaction with the reproductive tract, oviductal epithelial cells, oviductal fluid and microvesicles co-cultured with gametes/embryos represent the most appropriate in vitro models to mimic the physiological conditions in vivo.Reproduction (2016) 152 R127-R141

show abstract

Section: Oviductal Response To Spermmentioning

confidence: 99%

Oviductal response to gametes and early embryos in mammals

Maillo¹,

Sánchez‐Calabuig²,

Lopera-Vásquez³

et al. 2016

Reproduction

View full text Add to dashboard Cite

show abstract

“…2). Natural killer (NK) cells are abundant in the uterus, where they are thought to play important roles for embryo implantation and pregnancy maintenance (Bulmer & Lash 2015). Several factors, such as soluble HLA-G (sHLA-G), a major histocompatibility complex molecule secreted by fetal trophoblasts during early pregnancy, can activate NK cells (Rajagopalan & Long 1999, Rajagopalan et al 2006.…”

Section: Cellular Senescence and Uterine Agingmentioning

confidence: 99%

Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

Velarde

Menon

2016

Journal of Endocrinology

View full text Add to dashboard Cite

Cellular senescence is a phenomenon occurring when cells are no longer able to divide even after treatment with growth stimuli. Because senescent cells are typically associated with aging and age-related diseases, cellular senescence is hypothesized to contribute to the age-related decline in reproductive function. However, some data suggest that senescent cells may also be important for normal physiological functions during pregnancy. Herein, we review the positive and negative effects of cellular senescence on female reproductive aging and pregnancy. We discuss how senescent cells accelerate female reproductive aging by promoting the decline in the number of ovarian follicles and increasing complications during pregnancy. We also describe how cellular senescence plays an important role in placental and fetal development as a beneficial process, ensuring proper homeostasis during pregnancy.

show abstract

Understanding the correlation between artificial insemination and offspring health outcomes

Navarro-Rubio

Güell

2019

Birth Defects Research

View full text Add to dashboard Cite

Although numerous articles have shown intracytoplasmic sperm injection and in vitro fertilization to be correlated with increased risk of disease, a few works have been published on the risks associated with artificial insemination. Meanwhile, questions about the possible causes underlying these correlations have remained in the background. The main objective of this work is not to review the risks associated with artificial insemination, but rather to describe how developmental processes may be affected by these techniques. Thus, we offer a theoretical framework for understanding the possible causes that underlie the correlation between low‐complexity or milder techniques and offspring health outcomes.

show abstract

The Male Role in Pregnancy Loss and Embryo Implantation Failure

Abstract: More information about this series at

Cited by 6 publications

References 512 publications

Oviductal response to gametes and early embryos in mammals

Oviductal response to gametes and early embryos in mammals

Positive and negative effects of cellular senescence during female reproductive aging and pregnancy

Understanding the correlation between artificial insemination and offspring health outcomes

Contact Info

Product

Resources

About