The Major Histocompatibility System of the Rat (Ag-B or H-1 System)

Günther, Eberhard; Stark, O

doi:10.1007/978-3-642-95293-7_7

Cited by 44 publications

(16 citation statements)

References 166 publications

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“…Although the number of alleles is not a good measure of polymorphism (see Introduction) and although the data are quite incomplete, particularly for the hamster, the table suggests that there are differences in the degree of polymorphism among different mammals. The MHC polymorphism in the Syrian hamster appears to be low, perhaps not greater than that of other (non-MHC) polymorphic loci (Duncan & Streilein 1977); the MHC polymorphism in the rat appears to be intermediate between the hamster and the mouse (Glinther & Stark 1979, Wagener et al 1979) and the MHC polymorphism in the human and the mouse may be equally high (Bodmer et al 1977). Because of the incompleteness of the data one cannot be sure that * I, II = class I and class II, these differences are real but at this stage of study they appear to be.…”

Section: T Haplotypesmentioning

confidence: 88%

Polymorphism of the Mouse H‐2 Loci

Klein

Figueroa

1981

Immunological Reviews

152

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Section: T Haplotypesmentioning

confidence: 88%

Polymorphism of the Mouse H‐2 Loci

Klein

Figueroa

1981

Immunological Reviews

152

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“…Genetic analyses: The nomenclature of Serov (1973), Womack (1972aWomack ( , 1972bWomack ( , 1973, Gasser et al (1973), and Yamada et al (1980) is used for the esterase loci, of Mizuno and Suzuki (1978) for amylase, of French et al (1971) for hemoglobin B, of Nikaido and Yamada (1981) for male urinary protein, and of Gunther and Stark (1979) for RTJ haplotypes. Chi-squares for linkage were calculated by the method of Green (1963).…”

Section: Animalsmentioning

confidence: 99%

Genetic studies of RBC catalase in the rat (Rattus norvegicus).

Yamada

Nikaido

Kondo

1981

The Japanese journal of genetics

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A polymorphism of RBC catalases was found by starch gel electrophresis among inbred strains of rats. The slow migrating banding pattern (CS-1B) is dominant over the fast migrating banding pattern (CS-lA) and in progeny made by backcrossing F1 hybrids with CS-lA type parental strain the two types segregated 1:1. The designation Cs-i locus, with two alleles (Cs-ia, Cs-ib), is tentatively proposed. The Cs-1 locus is not linked with the linkage group (LG) I, II, IV, V, VI, VIII and the LG containing Amy-i. The Cs-jb allele is distributed among several common inbred strains of rats derived from the so-called Wistar strain in Japan and its origin is discussed.

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“…The histocompatibility features of the rats and the grafts (dermoepidermic and 150-300 mm: of area) were chosen in order to induce skin graft rejection in an 8-to 10-day period [ 17], As mentioned above, biop sies of the grafts were taken on the 2nd. 5th and 8th postoperative (p.o.)…”

Section: Allograft Rejection Studymentioning

confidence: 99%

Immunorestorative Effect of Thymostimulin on Surgery Immunodepression: Experimental Model

García-Lechuz

Navarro²,

Morandeira³

et al. 1993

Eur Surg Res

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The purpose of the present study is to ascertain the immunorestorative effect of two different drugs on immunodepression induced by small bowel surgical resection in an experimental model. The potential immunorestorative effect has been measured by the ability of the drug to avoid the delay of skin allograft rejection induced by surgery and the inhibition of CD4/CD8 index changes induced by surgery in spleen tissue. 120 Wistar-Furth rats (age 12–16 weeks) anesthetized with a single intramuscular dose of ketamine (25 mg), diazepine (4 mg) and atropine (0.1 mg) were allotted to two main groups. One group received a skin graft (SG) from Fisher 344 rats and was treated with placebo, Inmunoferón® (AM-3 polypeptidic drug) or TP-II (thymostimulin) before the experiment (groups I, II, III) or treated with placebo, Inmunoferón or TP-1 before the experiment and underwent enterectomy and anastomosis (groups IV, V, VI). On the 2nd, 5th and 8th postoperative days, biopsies of the SG were taken and the signs of rejection were microscopically studied and evaluated by a pathologist as zero, incipient, moderate or massive. The other group was treated similarly, but the animals did not receive a SG and were splenectomized 5 days later. CD4 and CD8 lymphocyte subpopulations were identified by means of immunoperoxidase technique and monoclonal antibodies. Thymostimulin is able to stimulate the presence of SG rejection signs on the 2nd postoperative day in nonenterectomized animals and on the 8th postoperative day in enterectomized rats and is able to avoid the decrease of the CD4/CD8 index in spleen tissue after surgical immunodepression. AM-3 has less effect on the presence of SG rejection signs and CD4/CD8 index than thymostimulin.

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The Major Histocompatibility System of the Rat (Ag-B or H-1 System)

Cited by 44 publications

References 166 publications

Polymorphism of the Mouse H‐2 Loci

Polymorphism of the Mouse H‐2 Loci

Genetic studies of RBC catalase in the rat (Rattus norvegicus).

Immunorestorative Effect of Thymostimulin on Surgery Immunodepression: Experimental Model

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